Research progress of microRNA-145 in endometriosis

GAO Shuang; XU Peng; WANG Bei-di; LI Li-yang; GUO Yu; KUANG Ye

doi:10.16766/j.cnki.issn.1674-4152.002201

Volume 19 Issue 11

Nov. 2021

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Article Navigation > Chinese Journal of General Practice > 2021 > 19(11): 1921-1924

GAO Shuang, XU Peng, WANG Bei-di, LI Li-yang, GUO Yu, KUANG Ye. Research progress of microRNA-145 in endometriosis[J]. Chinese Journal of General Practice, 2021, 19(11): 1921-1924. doi: 10.16766/j.cnki.issn.1674-4152.002201

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GAO Shuang, XU Peng, WANG Bei-di, LI Li-yang, GUO Yu, KUANG Ye. Research progress of microRNA-145 in endometriosis[J]. Chinese Journal of General Practice, 2021, 19(11): 1921-1924. doi: 10.16766/j.cnki.issn.1674-4152.002201

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Research progress of microRNA-145 in endometriosis

doi: 10.16766/j.cnki.issn.1674-4152.002201

GAO Shuang¹
, XU Peng²
, WANG Bei-di¹
, LI Li-yang¹
, GUO Yu¹
, KUANG Ye^{1
,
,}

1.
Department of Obstetrics and Gynaecology, the Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, China

Funds:

320675018061

Received Date: 2020-08-10
Available Online: 2022-02-15

Abstract

Abstract

Endometriosis (EMs) is a common oestrogen-dependent disease, the cause of which is not clear. Epigenetic abnormality may be a potential pathogenic mechanism of EM, which changes the response of hormones and environmental factors to gene expression. Amongst them, small microRNAs (miRNAs) are differentially expressed in EM and play a certain role in the occurrence and development of the disease. miRNAs are non-coding regulatory single-stranded RNAs that regulate gene expression at the transcription or post-transcription level by binding to the 3′ untranslated region of mRNA. Several studies have revealed that miRNAs are potentially powerful biomarkers of EM. Some of these dysregulated miRNAs are directly involved in the occurrence of diseases, whilst others are related to the existence of diseases. However, their biological role is unclear. Amongst these miRNAs, miR-145 has obvious differential expression in EM. miR-145 mediates cell adhesion molecules and cytoskeletal elements, such as plasminogen activator inhibitor-1, octamer-binding transcription factor-4 and FSCN1. miR-145 is also regulated by its upstream RNA molecules. For example, long non-coding RNA prostate cancer-associated transcript 1 can have an impact on the risk of EM through the miR-145 signalling pathway that targets and regulates the expression of specific genes. In addition, the changes of miR-145 expression levels may be related to infertility in EM. This study aims to describe the mechanism of action of miR-145 in EM, including cell angiogenesis, peritoneal adhesion, invasion, migration, proliferation, autophagy and infertility, in order to provide further theoretical support for the clinical treatment of EM.
- MicroRNA-145,
- Endometriosis,
- Pathogenesis

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References(48)

References

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Research progress of microRNA-145 in endometriosis

doi: 10.16766/j.cnki.issn.1674-4152.002201

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