Volume 20 Issue 1
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DING Shu-bo, ZHOU Zhen-zhen, LI Ming, HU Wang-yuan. Efficacy of pelvic short-course palliative radiotherapy for advanced rectal cancer[J]. Chinese Journal of General Practice, 2022, 20(1): 27-30. doi: 10.16766/j.cnki.issn.1674-4152.002268
Citation: DING Shu-bo, ZHOU Zhen-zhen, LI Ming, HU Wang-yuan. Efficacy of pelvic short-course palliative radiotherapy for advanced rectal cancer[J]. Chinese Journal of General Practice, 2022, 20(1): 27-30. doi: 10.16766/j.cnki.issn.1674-4152.002268
shu

Efficacy of pelvic short-course palliative radiotherapy for advanced rectal cancer

doi: 10.16766/j.cnki.issn.1674-4152.002268

  • Department of Radiation Oncology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, Zhejiang 321000, China

Funds:

 2020KY1002

 2012-3-010

  • Received Date: 2020-06-29
    Available Online: 2022-03-03
    Abstract
  •   Objective  To evaluate the efficacy and safety of pelvic short-course palliative radiotherapy in advanced rectal cancer with local symptoms, and to provide treatment strategies for palliative radiotherapy for advanced rectal cancer.  Methods  Total 51 patients with advanced rectal cancer who were admitted to Affiliated Jinhua Hospital, Zhejiang University School of Medicine from May 2016 to April 2020 were selected as the research subjects. The age ranged from 43 to 74 years, and the median age was 61 years old. There were 28 males and 23 females. The rates of pain, bleeding and intestinal obstruction in 51 patients were 66.7%(34/51), 68.6%(35/51), 39.2%(20/51), respectively. All 51 patients were underwent pelvic 5 Gy×5F short-course radiotherapy. The changes in the scores of pain, bleeding and intestinal obstruction symptoms before and after treatment were compared using the symptom score of 0-3 method. The side effects of short-course radiotherapy and the duration of symptom relief were assessed.  Results  In 51 cases, the complete and partial relief of pain was 61.8%(21/34) and 29.4%(10/34), the complete and partial relief of rectal hemorrhage was 74.3%(26/35) and 20.0%(7/35), the complete and partial relief of intestinal obstruction was 55.0%(11/20) and 35.0%(7/20), respectively. The overall symptom complete response was 21.6%, and the partial response was 43.1%. The side effects of pelvic radiotherapy were slight. The median effective duration of pain, hemorrhage, and obstruction were 6.5 months, 8.9 months, and 3.8 months, respectively. Five patients with initial unresectable and 8 patients with potentially resectable advanced stage underwent radical surgical resection. One patient with an initial obstruction score of 2 points underwent enterostomy after 5.5 months of radiotherapy. The overall 1-year, 2-year, and 3-year survival rates were 86.3%(44/51), 62.7%(32/51)and 45.1%(23/51), respectively.  Conclusion  The short-course radiotherapy of pelvic 5Gy×5F has a good palliative effect on the advanced rectal cancer. Short-course radiotherapy allows most patients with intestinal obstruction to avoid surgery, improves the radical operation rate of advanced rectal cancer. It has important significance for the transformation treatment of advanced rectal cancer.

     

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