Volume 20 Issue 1
Jan.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(1): 157-160
LI Dan, SUN Guo-hua, CHEN Xin-chun, KOU Yong-mei. Relationship between uric acid level and cardiovascular risk factors in overweight and obese children in Tangshan City[J]. Chinese Journal of General Practice, 2022, 20(1): 157-160. doi: 10.16766/j.cnki.issn.1674-4152.002301
Citation: LI Dan, SUN Guo-hua, CHEN Xin-chun, KOU Yong-mei. Relationship between uric acid level and cardiovascular risk factors in overweight and obese children in Tangshan City[J]. Chinese Journal of General Practice, 2022, 20(1): 157-160. doi: 10.16766/j.cnki.issn.1674-4152.002301
shu

Relationship between uric acid level and cardiovascular risk factors in overweight and obese children in Tangshan City

doi: 10.16766/j.cnki.issn.1674-4152.002301

  • Department of pediatrics, Tangshan Municipal People's Hospital, Tangshan, Hebei 063001, China

Funds:

 20191599

  • Received Date: 2021-01-24
    Available Online: 2022-03-03
    Abstract
  •   Objective  To understand the relationship between uric acid level and cardiovascular risk factors in overweight and obesity children in Tangshan, and to provide theoretical basis for preventing hyperuricemia and reducing the risk of cardiovascular disease.  Methods  Total 560 overweight and obesity children screened by physical examination of school-age children in Tangshan City from 2018 to 2019 were taken as the research objects. Height, weight, waist circumference (WC), blood pressure (BP) were measured, body mass index (BMI) was calculated. Uric acid (UA), fasting blood glucose (FPG), total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) were detected. The relationship between uric acid and cardiovascular risk factors was analyzed by sex stratification.  Results  (1) The detection rates of boys and girls hyperuricemia were 36.50% and 26.26% respectively (P < 0.05). (2) With the increase of UA level, SBP and DBP increased and HDL-C decreased in boys, SBP, FPG, TC, TG, LDL-C increased and HDL-C decreased in girls, the difference between groups was statistically significant (all P < 0.05). (3) UA level in boys was negatively correlated with HDL-C (r=-0.154, P < 0.05), positively correlated with TG and SBP (r=0.141, 0.238, all P < 0.05), meanwhile UA level in girls was negatively correlated with HDL-C (r=-0.700, P < 0.05), and positively correlated with LDL-C and TG (r=0.615, 0.341, all P < 0.05). (4) The influencing factors of hyperuricemia in boys were age, low HDL-C, abnormal fasting blood glucose, overweight/obesity, meanwhile the influencing factors of hyperuricemia in girls were age, high TC, low HDL-C, high TG, overweight/obesity and hypertension.  Conclusion  UA level of overweight and obesity children in Tangshan City is related to cardiovascular risk factors. Uric acid levels of overweight and obesity children should be monitored regularly.

     

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