Volume 20 Issue 3
Mar.  2022
Turn off MathJax
Article Contents
Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(3): 438-440
XU Jun. Incidence of insulin resistance in obese school-age children and its correlation with autonomic nerve function[J]. Chinese Journal of General Practice, 2022, 20(3): 438-440. doi: 10.16766/j.cnki.issn.1674-4152.002372
Citation: XU Jun. Incidence of insulin resistance in obese school-age children and its correlation with autonomic nerve function[J]. Chinese Journal of General Practice, 2022, 20(3): 438-440. doi: 10.16766/j.cnki.issn.1674-4152.002372
shu

Incidence of insulin resistance in obese school-age children and its correlation with autonomic nerve function

doi: 10.16766/j.cnki.issn.1674-4152.002372

  • Department of Internal Medicine, Hangzhou Children's Hospital, Hangzhou, Zhejiang 310000, China

Funds:

 2017KY556

  • Received Date: 2021-04-12
    Available Online: 2022-08-13
    Abstract
  •   Objective  To investigate the incidence of insulin resistance (IR) in obese school-age children and its correlation with heart rate deceleration capacity (DC), heart rate acceleration capacity (AC) and heart rate variability (HRV).  Methods  A total of 122 obese school-age children were admitted to our hospital between May 2018 and May 2019 as the research objects, and they were divided into the IR group (69 cases) and non-IR group (53 cases) on the basis of the IR index (IRI) calculation results. The general conditions of both groups were recorded. The results of DC, AC and HRV in both groups were compared, and the Pearson correlation coefficient was analysed to determine the correlation between IRI indicators and results of DC, AC and HRV.  Results  The IR group had lower DC, SDNN, SDANN and HF (P < 0.05) and higher AC than the non-IR group (P < 0.05). The two groups were negatively correlated with DC, SDNN, SDANN, RMSSD, LF and HF (r=-0.390, -0.451, -0.290, -0.215, -0.259, -0.324, all P < 0.05) and positively correlated with AC (r=0.584, P < 0.05). In the IR group, IRI indicators were negatively correlated with SDNN, RMSSD and LF (r=-0.517, -0.370, -0.355, all P < 0.05) and positively correlated with AC (r=0.519, P < 0.05). In the non-IR group, IRI indicators were negatively correlated with RMSSD and HF (r=-0.343, -0.344, all P < 0.05).  Conclusion  The heart autonomic nerve function of obese school-age children with IR is severely damaged, as evidenced by a decrease in DC-and HRV-related indicators and an increase in AC level. Moreover, the higher the degree of IR in the child, the more severe the damage of autonomic nerve function.

     

    • FullText(HTML)
  • loading
    • References(20)
  • [1]
    张帆, 都鹏飞. 儿童肥胖与心血管损害的表现与干预[J]. 中华全科医学, 2018, 16(4): 512-513. http://www.zhqkyx.net/article/id/d7a1cf87-151d-47ef-92f0-173ca6be3a4d

    ZHANG F, DU P F. Manifestation and intervention of childhood obesity and cardiovascular damage[J]. Chinese Journal of General Practice, 2018, 16(4): 512-513. http://www.zhqkyx.net/article/id/d7a1cf87-151d-47ef-92f0-173ca6be3a4d
    [2]
    王嫣嫣, 熊丰. 儿童肥胖与代谢综合征相关性研究进展[J]. 现代医药卫生, 2015, 31(11): 1649-1652. doi: 10.3969/j.issn.1009-5519.2015.11.018

    WANG Y Y, XIONG F. Research progress of correlation between childhood obesity and metabolic syndrome[J]. Journal of Modern Medicine & Health, 2015, 31(11): 1649-1652. doi: 10.3969/j.issn.1009-5519.2015.11.018
    [3]
    青丽, 彭璐婷, 刘倩琦, 等. 肥胖儿童青少年胰岛素抵抗的临床特征及其与代谢并发症的关系[J]. 中华实用儿科临床杂志, 2020, 35(11): 847-851. doi: 10.3760/cma.j.cn101070-20190214-00101

    QING L, PENG LT, LIU Q Q, et al. Clinical characteristics of insulin resistance and its relationship with metabolic complications in obese children and adolescents[J]. Chinese Journal of Applied Clinical Pediatrics, 2020, 35(11): 847-851. doi: 10.3760/cma.j.cn101070-20190214-00101
    [4]
    邱梅, 文红霞, 黄小力, 等. 维生素D缺乏对学龄前期肥胖儿童心脏自主神经功能的影响[J]. 中国当代儿科杂志, 2018, 20(9): 753-757. https://www.cnki.com.cn/Article/CJFDTOTAL-DDKZ201809015.htm

    QIU M, WEN HX, HUANG X L, et al. EEffect of vitamin D deficiency on cardiac autonomic nerve function in obese preschool children[J]. Chinese Journal of Contemporary Pediatrics, 2018, 20(9): 753-757. https://www.cnki.com.cn/Article/CJFDTOTAL-DDKZ201809015.htm
    [5]
    PLAZA-FLORIDO A, MIGUELES J H, MORA-GONZALEZ J, et al. Heart rate is a better predictor of cardiorespiratory fitness than heart rate variability in overweight/obese children: The active brains project[J]. Front Physiol, 2019, 10(7): 510-511.
    [6]
    陈春明, 马冠生, 季成叶, 等. 中国学龄儿童少年超重和肥胖预防与控制指南(试用)[M]. 北京: 人民卫生出版社, 2008: 122-123.

    CHEN C M, MA G S, JI C Y, et al. Prevention of overweight and obesity among Chinese school-age children and adolescents And control guide (trial)[M]. Beijing: People's Health Publishing House, 2008: 122-123.
    [7]
    KAPRAL N, MILLER S E, SCHARF R J, et al. Associations between birthweight and overweight and obesity in school-age children[J]. Pediatr Obes, 2018, 13(6): 333-341. doi: 10.1111/ijpo.12227
    [8]
    LARTEY A, MARQUIS G S, ARYEETEY R, et al. Lipid profile and dyslipidemia among school-age children in urban ghana[J]. BMC Public Health, 2018, 18(1): 320-321. doi: 10.1186/s12889-018-5196-0
    [9]
    黄纯, 谈驰, 王新, 等. 学龄前儿童单纯性肥胖神经行为与血清IGF-1 GH水平的关系[J]. 河北医学, 2019, 25(2): 211-215. doi: 10.3969/j.issn.1006-6233.2019.02.010

    HUANG C, TAN C, WANG X, et al. Relationship between neurobehavioral behavior of simple obesity and serum IGF-1 and GH levels in preschool children[J]. Hebei Medicine, 2019, 25(2): 211-215. doi: 10.3969/j.issn.1006-6233.2019.02.010
    [10]
    赵丽丽, 丁显春. 心血管危险因素对学龄期儿童肥胖型别的影响[J]. 中国妇幼保健, 2015, 30(15): 2400-2403. https://www.cnki.com.cn/Article/CJFDTOTAL-ZFYB201515043.htm

    ZHAO L L, DING X C. Influence of cardiovascular risk factors on obesity types of school-age children[J]. Maternal and Child Health Care of China, 2015, 30(15): 2400-2403. https://www.cnki.com.cn/Article/CJFDTOTAL-ZFYB201515043.htm
    [11]
    柯琼可, 邱莹, 甘晓丹, 等. 儿童血清Omentin-1表达水平与肥胖及胰岛素抵抗的关系研究[J]. 中华肥胖与代谢病电子杂志, 2020, 6(1): 33-36. doi: 10.3877/cma.j.issn.2095-9605.2020.01.007

    KE Q K, QIU Y, GAN X D, et al. Relationship between serum Omentin-1 expression and obesity and insulin resistance in children[J]. Chinese Journal Of Obesity and Metabolic Diseases (Electronic Edition), 2020, 6(1): 33-36. doi: 10.3877/cma.j.issn.2095-9605.2020.01.007
    [12]
    黄小力, 文红霞, 易兰芬, 等. 超重、肥胖儿童与代谢综合征患儿心率减速力的研究[J]. 临床儿科杂志, 2017, 35(10): 725-728. doi: 10.3969/j.issn.1000-3606.2017.10.002

    HUANG X L, WEN H X, YI L F, et al. A study on deceleration capacity of heart rate in overweight, obesity children, and children with metabolic syndrome[J]. Journal of Clinical Pediatrics, 2017, 35(10): 725-728. doi: 10.3969/j.issn.1000-3606.2017.10.002
    [13]
    张京杨, 曹晓晓, 文红霞, 等. 肥胖儿童心率变异特征与血脂代谢、脂肪细胞因子含量的相关性分析[J]. 中国现代医学杂志, 2017, 27(18): 79-82. doi: 10.3969/j.issn.1005-8982.2017.18.016

    ZHANG J Y, CAO X X, WEN H X, et al. Correlations of heart rate variability with lipid metabolism and adipocytokines in obese children[J]. China Journal of Modern Medicine, 2017, 27(18): 79-82. doi: 10.3969/j.issn.1005-8982.2017.18.016
    [14]
    徐飞, 徐菁, 谢浩. 体力活动水平和心肺耐力对肥胖者心率变异性的影响: 一项横断面研究[J]. 中国运动医学杂志, 2019, 38(3): 187-193. https://www.cnki.com.cn/Article/CJFDTOTAL-YDYX201903004.htm

    XU F, XU J, HAO X. The Effect of Physical activity level and cardiorespiratory fitness on heart rate variability in obese adults: A cross-sectional study[J]. Chinese Journal of Sports Medicine, 2019, 38(3): 187-193. https://www.cnki.com.cn/Article/CJFDTOTAL-YDYX201903004.htm
    [15]
    唱一男, 谭新睿, 肖延风, 等. 肥胖儿童脂肪组织CIDEC表达及与胰岛素抵抗2的相关性研究[J]. 中国儿童保健杂志, 2020, 8(31): 1-5. https://www.cnki.com.cn/Article/CJFDTOTAL-ERTO202002009.htm

    CHANG Y N, TAN X R, XIAO Y F, et al. Study on the correlation between cell death-inducing DNA fragmentation factor 45-like effector C expression in adipose tissue and insulin resistance in obese children[J]. Chinese Journal of Child Health Care, 2020, 8(31): 1-5. https://www.cnki.com.cn/Article/CJFDTOTAL-ERTO202002009.htm
    [16]
    王成祥, 常绍鸿, 谢遂亮, 等. 不同肥胖程度儿童血清Apo A5、SIRT4水平与糖脂代谢及胰岛素抵抗的相关性[J]. 中国现代医学杂志, 2019, 29(22): 89-93. doi: 10.3969/j.issn.1005-8982.2019.22.018

    WANG C X, ChANG S H, XIE S L, et al. Relevance between serum Apo A5, SIRT4 levels and glycolipid metabolism, insulin resistance in children with different degrees of obesity[J]. China Journal of Modern Medicine, 2019, 29(22): 89-93. doi: 10.3969/j.issn.1005-8982.2019.22.018
    [17]
    黄芳, 文红霞, 曹晓晓. 学龄期肥胖儿童胰岛素抵抗与心率变异性及心率减速力的相关性[J]. 临床儿科杂志, 2018, 36(7): 486-489. doi: 10.3969/j.issn.1000-3606.2018.07.002

    HUANG F, WEN H X, CAO X X. Correlation of insulin resistance with heart rate variability and heart rate deceleration in school-age obese children[J]. Journal of Clinical Pediatrics, 2018, 36(7): 486-489. doi: 10.3969/j.issn.1000-3606.2018.07.002
    [18]
    余仁强, 周勤, 马路一. 儿童肥胖与心血管疾病危险因素的关系研究进展[J]. 新乡医学院学报, 2016, 33(1): 78-80. https://www.cnki.com.cn/Article/CJFDTOTAL-XXYX201601023.htm

    YU R Q, ZhOU Q, MA L Y. Research progress on the relationship between childhood obesity and cardiovascular risk factors[J]. Journal of Xinxiang Medical University, 2016, 33(1): 78-80. https://www.cnki.com.cn/Article/CJFDTOTAL-XXYX201601023.htm
    [19]
    高阿宁. 儿童肥胖指数与血脂及心率变异性临床研究[J]. 陕西医学杂志, 2019, 48(1): 19-21. doi: 10.3969/j.issn.1000-7377.2019.01.006

    GAO A N. Clinical research between childhood obesity index and blood lipid and heart rate variability[J]. Shaanxi Medical Journal, 2019, 48(1): 19-21. doi: 10.3969/j.issn.1000-7377.2019.01.006
    [20]
    易兰芬, 文红霞, 黄小力, 等. 学龄期肥胖儿童心脏自主神经功能分析[J]. 中国当代儿科杂志, 2017, 19(5): 524-528. https://www.cnki.com.cn/Article/CJFDTOTAL-DDKZ201705010.htm

    YI L F, WEN H X, HUANG X L, et al. Cardiac autonomic nerve function in obese school-age children[J]. Chinese Journal of Contemporary Pediatrics, 2017, 19(5): 524-528. https://www.cnki.com.cn/Article/CJFDTOTAL-DDKZ201705010.htm
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Tables(3)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (222) PDF downloads(2) Cited by()
    Proportional views
    Related

    Address：No. 287, Changhuai Road, Bengbu, Anhui Province, 233004, P.R.ChinaphoneNo：0552-3066635； 0552-3051890Email：zhqkyx@163.com

    Copyright © Chinese Journal of General Practice皖ICP备2020018345号-2

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return