Volume 20 Issue 3
Mar.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(3): 450-453
CHEN Shou-lin, ZHU Sheng-zhi, YU Chang, XIE Shu-guang, ZHENG Cheng-ying. Correlation between serum indexes and cognitive function in elderly patients with depression[J]. Chinese Journal of General Practice, 2022, 20(3): 450-453. doi: 10.16766/j.cnki.issn.1674-4152.002375
Citation: CHEN Shou-lin, ZHU Sheng-zhi, YU Chang, XIE Shu-guang, ZHENG Cheng-ying. Correlation between serum indexes and cognitive function in elderly patients with depression[J]. Chinese Journal of General Practice, 2022, 20(3): 450-453. doi: 10.16766/j.cnki.issn.1674-4152.002375
shu

Correlation between serum indexes and cognitive function in elderly patients with depression

doi: 10.16766/j.cnki.issn.1674-4152.002375
  • 1.

    Department of Laboratory Medicine, Ningbo Kangning Hospital, Ningbo, Zhejiang 315201, China

Funds:

 2019RC079

  • Received Date: 2021-03-12
    Available Online: 2022-08-13
    Abstract
  •   Objective  To explore the correlation between serum index and cognitive function in elderly patients with depression and provide reference for clinical diagnosis of senile depression.  Methods  From June 2018 to June 2019, 50 elderly patients with depression in Ningbo Kangning Hospital were selected as the depression group, and 50 healthy people were selected as the control group. The cognitive function, depression degree and serum indexes were compared between the two groups. Pearson method was used to analyse the correlation between serum indicators and cognitive function in depression group.  Results  The Hamilton depression scale (HAMD) score of the depression group was (25.44±4.68) points, which was significantly higher than that of the control group [(4.52±2.24) points, P < 0.05], and the mini-mental state examination (MMSE) score was (22.36±2.83) points, which was significantly lower than that of the control group [(27.02±2.35) points, P < 0.05]. There was a negative correlation between HAMD score and MMSE score in the depression group (r=-0.420, P < 0.05). The levels of 5-hydroxytryptamine (5-HT), dopamine (DA) and norepinephrine (NE) in the depression group were significantly lower than those in the control group (all P < 0.05), were negatively correlated with HAMD score (r=-0.532, -0.477, -0.494, all P < 0.05) and positively correlated with MMSE score (r=0.525, 0.476, 0.506, all P < 0.05). The levels of homocysteine (Hcy), Cystatin-C (Cys-C), interleukin (IL)-1β and IL-18 were significantly higher than those in the control group (all P < 0.05), were positively correlated with HAMD score (r=0.444, 0.457, 0.575, 0.540, all P < 0.05) and negatively correlated with MMSE score (r=-0.404, -0.372, -0.594, -0.419, all P < 0.05).  Conclusion  The level of serum indexes in elderly patients with depression is closely related to the degree of depression and cognitive function. With the increase of depression degree and the decrease of cognitive level, the levels of 5-HT, DA and NE gradually decrease, whereas the levels of Hcy, Cys-C, IL-1β and IL-18 gradually increase.

     

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