Volume 20 Issue 3
Mar.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(3): 464-467
LI De-min, LU Yong-zheng, QIN Zhen, XU Yan-yan, ZHANG Li, ZHANG Jin-ying, TANG Jun-nan. Cell derivatives in heart injury repair progress and application prospects[J]. Chinese Journal of General Practice, 2022, 20(3): 464-467. doi: 10.16766/j.cnki.issn.1674-4152.002379
Citation: LI De-min, LU Yong-zheng, QIN Zhen, XU Yan-yan, ZHANG Li, ZHANG Jin-ying, TANG Jun-nan. Cell derivatives in heart injury repair progress and application prospects[J]. Chinese Journal of General Practice, 2022, 20(3): 464-467. doi: 10.16766/j.cnki.issn.1674-4152.002379
shu

Cell derivatives in heart injury repair progress and application prospects

doi: 10.16766/j.cnki.issn.1674-4152.002379
  • 1.

    Department of Cardiology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China

Funds:

 81800267

 202300410362

  • Received Date: 2021-06-18
    Available Online: 2022-08-13
    Abstract
  • Acute myocardial infarction (AMI) is still the leading cause of death in patients with coronary heart disease. New treatment strategies for repairing the damaged heart after AMI need to be developed. The latest research shows that cell derivatives exhibit great potential in the repair of heart damage, which is a hot spot in current medical research. Cell derivatives include extracellular vehicles (EVs), non-coding RNA, and growth factors. Combined with the latest research progress, this review shows the changes and functions of EVs derived from cardiomyocytes, endothelial cells and immune cells after AMI. The changes and effects of microribonucleic acid, long non-coding ribonucleic acid and circular ribonucleic acid in preclinical and clinical research after AMI are summarised. The focus is on the changes and effects of vascular endothelial growth factor and fibroblast growth factor after AMI. Finally, from the perspective of clinical application, the research on EVs, non-coding RNA, growth factors as biomarkers for the diagnosis and prediction of clinical disease progression, and the use of these cell derivatives as treatment methods for AMI are summarised. In short, cell derivatives have great potential in the repair of heart damage and are worthy of in-depth study.

     

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