Volume 20 Issue 3
Mar.  2022
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XU Wen-li, CUI Yun, FANG Teng-duo. Medication rule of Professor Cui Yun in treating oligoasthenozoospermia based on data mining[J]. Chinese Journal of General Practice, 2022, 20(3): 473-477. doi: 10.16766/j.cnki.issn.1674-4152.002381
Citation: XU Wen-li, CUI Yun, FANG Teng-duo. Medication rule of Professor Cui Yun in treating oligoasthenozoospermia based on data mining[J]. Chinese Journal of General Practice, 2022, 20(3): 473-477. doi: 10.16766/j.cnki.issn.1674-4152.002381
shu

Medication rule of Professor Cui Yun in treating oligoasthenozoospermia based on data mining

doi: 10.16766/j.cnki.issn.1674-4152.002381
  • 1.

    Department of Reproduction, the Headquarters of Ningbo Fenghua District TCM Hospital Medical Community, Ningbo, Zhejiang 315500, China

Funds:

 GZS20120030

 2017ZA043

 2018ZA031

  • Received Date: 2021-03-21
    Available Online: 2022-08-13
    Abstract
  •   Objective  To investigate the medication rule, prescription experience and clinical ideas of Professor Cui Yun in treating oligoasthenozoospermia.  Methods  The first prescriptions of 200 oligoasthenozoospermia patients who were treated by Professor Cui Yun between January 2019 and December 2019 in Ningbo TCM Hospital were collected and extracted. The database was established. The nature, taste, meridian tropism and efficacy of drugs were analysed by descriptive statistics, and the drug combinations and prescriptions commonly used by Professor Cui Yun in the treatment of oligoasthenozoospermia were analysed use cluster analysis.  Results  There were 87 herbs and 2 425 frequencies in the 200 prescriptions. The frequency of the top 50 herbs was up to 95.46%, and the top five herbs were energy-restoring herbs, heat-clearing herbs, urine-promoting herbs, blood circulation-promoting herbs and astringent herbs. The properties were cold, warm and neutral, and never great cold or hot herbs. The tastes were bitter, sweet and acrid. The main meridian entries were spleen, kidney and liver. The cluster analysis showed that the common prescriptions of Professor Cui Yun in treating oligoasthenozoospermia were Liu wei Di huang Soup, Huoxue Prescription, Dang gui Liu huang Soup, Dang gui Buxue Soup, Tuomin Soup and Erzhi Pills, and the common drug groups were Guya and Maiya, Maidong and Wuweizi, Shengdiyu and Huzhang, Xiqiancao Guanzhong and Shengma.  Conclusion  The medication rule of Professor Cui Yun in treating oligoasthenozoospermia complies with the pathological mechanism of kidney deficiency, damp heat and stasis toxin. The prescription is based on supporting weakness, taking clearing away heat and urine, activating blood circulation into account, and attaching importance to spleen and kidney, or liver and kidney. On the other hand, the data mining of the herbs' property reflects the equal stress on coldness and warmness, removing and tonifying, the prescription is gentle and flexible in brief.

     

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