Volume 20 Issue 4
Apr.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(4): 673-677
REN Li-li, YAO Qing-hua, CAO Wen-ming, HU Yi-juan, ZHANG Yong-jun, ZHANG Bo, CAI Hu. Effect of Sanhuang Sanxian Decoction on cancer-related fatigue in patients with advanced breast cancer of spleen and kidney deficiency type[J]. Chinese Journal of General Practice, 2022, 20(4): 673-677. doi: 10.16766/j.cnki.issn.1674-4152.002427
Citation: REN Li-li, YAO Qing-hua, CAO Wen-ming, HU Yi-juan, ZHANG Yong-jun, ZHANG Bo, CAI Hu. Effect of Sanhuang Sanxian Decoction on cancer-related fatigue in patients with advanced breast cancer of spleen and kidney deficiency type[J]. Chinese Journal of General Practice, 2022, 20(4): 673-677. doi: 10.16766/j.cnki.issn.1674-4152.002427
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Effect of Sanhuang Sanxian Decoction on cancer-related fatigue in patients with advanced breast cancer of spleen and kidney deficiency type

doi: 10.16766/j.cnki.issn.1674-4152.002427
  • 1.

    Department of Integrated Chinese and Western Medicine, Cancer Hospital Affiliated to the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, Zhejiang 310022, China

Funds:

 2019ZB016

  • Received Date: 2021-03-10
    Abstract
  •   Objective  To observe the effect of Sanhuang Sanxian Decoction on cancer-related fatigue (CRF) in patients with advanced breast cancer of spleen kidney deficiency type and to provide reference for improving the quality of life of patients with advanced breast cancer.  Methods  Eighty cases of advanced breast cancer patients of spleen kidney deficiency type in Zhejiang Cancer Hospital from September 2019 to May 2020 were randomly divided into the control group (40 cases) and observation group (40 cases). The control group was given palliative chemotherapy and symptomatic treatment, whereas the observation group was treated on the basis of the control group in combination with Sanhuang Sanxian Decoction. The Karnofsky performance scale (KPS), traditional Chinese medicine (TCM) clinical symptom score, Piper Fatigue Scale scores, serum cytokines and T lymphocyte subsets were compared before and after treatment, and the adverse reactions were recorded.  Results  After treatment, the TCM clinical symptom score, Piper Fatigue Scale score and tumour necrosis factor-α and interleukin (IL)-4 levels in the observation group were lower than those in the control group, whereas the KPS score and interferon-γ and IL-2 levels in the observation group were higher than those in the control group (P < 0.05). After treatment, the CD4+, CD8+ and CD4+/CD8+ ratio in the observation group were better than those in the control group (40.30±11.21)% vs. (35.06±9.37)%, (15.30±3.29)% vs. (17.17±3.53)%, (2.52±0.48)% vs. (1.90±0.41)%, respectively, all P < 0.05. The incidence of adverse reactions in the observation group was lower than that in the control group (10.00% vs. 27.50%, P < 0.05).  Conclusion  Sanhuang Sanxian Decoction can effectively improve the clinical symptoms and quality of life of patients with advanced breast cancer of spleen kidney deficiency type, relieve CRF symptoms of patients with advanced breast cancer, reduce the level of inflammatory factors and improve the immune capacity of the body, and it is safe and effective.

     

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