Volume 20 Issue 6
Jun.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(6): 1027-1030
FANG Bin-yu, ZHU Ting, ZHANG Shu-xia, SUN Xiao-bo, SUN Gui-bo, YU Lei. Research progress on the molecular mechanism of panax notoginseng saponins against ischemic stroke[J]. Chinese Journal of General Practice, 2022, 20(6): 1027-1030. doi: 10.16766/j.cnki.issn.1674-4152.002516
Citation: FANG Bin-yu, ZHU Ting, ZHANG Shu-xia, SUN Xiao-bo, SUN Gui-bo, YU Lei. Research progress on the molecular mechanism of panax notoginseng saponins against ischemic stroke[J]. Chinese Journal of General Practice, 2022, 20(6): 1027-1030. doi: 10.16766/j.cnki.issn.1674-4152.002516
shu

Research progress on the molecular mechanism of panax notoginseng saponins against ischemic stroke

doi: 10.16766/j.cnki.issn.1674-4152.002516
  • 1.

    School of Pharmacy, Harbin University of Commerce, Harbin, Heilongjiang 150076, China

Funds:

 U20A20405

 202102AA310048

  • Received Date: 2021-10-11
    Available Online: 2022-09-21
    Abstract
  • Stroke has a high recurrence rate, high disability rate and high fatality rate. Ischemic stroke is a common type of stroke, accounting for 70% of the incidence of stroke, it is a risk factor that reduces the life expectancy of Chinese residents. The pathological mechanism of ischemic stroke is complex, and previous neuroprotective methods are limited to a single mechanism. Such drugs cannot fully inhibit the complex pathophysiological cascade of patients with ischemic stroke. Drugs derived from natural products contain complex chemical components and can act on different targets of the disease at the same time. Therefore, the use of traditional Chinese medicine to combat ischemic stroke remains the current focus of research and development. The traditional Chinese medicine panax notoginseng has a long history of medicinal use. It is derived from the dry roots and rhizomes of panax notoginseng, a plant belonging to the family Araliaceae. Saponins include glycol-type ginsenosides, triol-type ginsenosides and special types of saponins. Panax notoginseng saponins have a definite protective effect on ischemic stroke. It has been reported that they can inhibit calcium overload, anti-oxidative stress, anti-inflammatory, anti-pyrolysis and anti-apoptosis agents, repair the blood-brain barrier, promote angiogenesis, and regulate intestinal flora. At the same time, panax notoginseng saponins have shown a synergistic effect in the combined application with astragaloside IV, geniposide, salvia polyphenolic acid and borneol. Panax notoginseng saponins have shown potential application value and great value in the prevention and treatment of stroke, indicating their prospects for the development of medicinal use. Therefore, we will summarise the three aspects of the saponin chemical components in notoginsenosides, the pharmacological effects of panax notoginseng saponins against ischemic stroke and the combination of notoginsenosides against ischemic stroke.

     

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