Volume 20 Issue 6
Jun.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(6): 1056-1061
WU Tong, WANG Yuan-zhong, LI Wei-li, YU Xin-hui. Meta-analysis of tonifying kidney and invigorating spleen in the treatment of recurrent abortion[J]. Chinese Journal of General Practice, 2022, 20(6): 1056-1061. doi: 10.16766/j.cnki.issn.1674-4152.002523
Citation: WU Tong, WANG Yuan-zhong, LI Wei-li, YU Xin-hui. Meta-analysis of tonifying kidney and invigorating spleen in the treatment of recurrent abortion[J]. Chinese Journal of General Practice, 2022, 20(6): 1056-1061. doi: 10.16766/j.cnki.issn.1674-4152.002523
shu

Meta-analysis of tonifying kidney and invigorating spleen in the treatment of recurrent abortion

doi: 10.16766/j.cnki.issn.1674-4152.002523
  • 1.

    Graduate School of Anhui University of Chinese Medicine, Hefei, Anhui 230031, China

Funds:

 81804233

 2020yfyzc28

  • Received Date: 2021-12-10
    Available Online: 2022-09-21
    Abstract
  •   Objective  To systematically evaluate the clinical efficacy of tonifying kidney and invigorating spleen in the treatment of recurrent abortion using Meta-analysis.  Methods  Literature on the treatment of recurrent abortion by tonifying kidney and spleen was retrieved from the database construction until September 2021. Meta-analysis was conducted by RevMan 5.4 software.  Results  Finally, 17 literatures were included. Meta-analysis showed that the effective rate of the tonifying kidney and invigorating spleen treatment group was higher than that of the control group without tonifying kidney and invigorating spleen therapy [risk ratio (RR)=1.34, 95% CI: 1.26 to 1.43, P < 0.001]. The success rate of pregnancy of the treatment group was better than that of control group (RR=1.38, 95% CI: 1.22 to 1.56, P < 0.001). Traditional Chinese medical syndrome score of the treatment group was better than the control group [standard mean difference (SMD)=-1.69, 95% CI: -2.20 to-1.18, P < 0.001]. There was no significant difference in the positive conversion of closed antibody between the two groups (RR=1.12, 95% CI: 0.92 to 1.36, P=0.250). There was no significant difference in blood human chorionic gonadotrophin (HCG) value between the two groups [mean difference (MD)=33 861.57, 95% CI: -25 012.30 to 92 735.43, P=0.260]. The progestin value of the treatment group was better than the control group (MD=7.31, 95% CI: 2.17 to 12.46, P=0.005).  Conclusion  The method of tonifying kidney and invigorating spleen has advantages in improving the clinical effective rate, pregnancy success rate, TCM syndrome score and blood progestin, but there is no significant difference in blocking antibody positive conversion and blood HCG value compared with western medicine. However, due to the limited sample size and relatively low article quality in this study, as well as selection bias and measurement bias, the results are affected to varying degrees. Therefore, more high-quality controlled clinical trials are needed for validation in future studies.

     

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