Volume 20 Issue 7
Jul.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(7): 1094-1097
DU Li, XU Yuan, ZHANG Lian, XU Gui-hua, WANG Gui-fen, LIU Zhen-jie. Effect of self-designed cancer pain analgesic plaster combined with oxycodone hydrochloride on refractory cancer pain[J]. Chinese Journal of General Practice, 2022, 20(7): 1094-1097. doi: 10.16766/j.cnki.issn.1674-4152.002531
Citation: DU Li, XU Yuan, ZHANG Lian, XU Gui-hua, WANG Gui-fen, LIU Zhen-jie. Effect of self-designed cancer pain analgesic plaster combined with oxycodone hydrochloride on refractory cancer pain[J]. Chinese Journal of General Practice, 2022, 20(7): 1094-1097. doi: 10.16766/j.cnki.issn.1674-4152.002531
shu

Effect of self-designed cancer pain analgesic plaster combined with oxycodone hydrochloride on refractory cancer pain

doi: 10.16766/j.cnki.issn.1674-4152.002531
  • 1.

    Internal Medicine-Oncology, Quzhou Hospital of Traditional Chinese Medicine, Quzhou, Zhejiang 324002, China

Funds:

 81970398

  • Received Date: 2021-10-29
    Available Online: 2022-09-23
    Abstract
  •   Objective  To observe the effect of self-designed external application of cancer pain analgesic plaster combined with oxycodone hydrochloride in the treatment of refractory cancer pain.  Methods  A total of 102 patients with refractory cancer pain admitted to Quzhou Hospital of Traditional Chinese Medicine from January 2019 to June 2020 were selected and divided into the control group and observation group, with 51 cases in each group. The control group was given oxycodone hydrochloride sustained-release tablets, and the observation group was treated with self-designed external application of cancer pain analgesic plaster on the basis of the control group. The clinical pain treatment effect, digital pain score (NRS), dosage of oxycodone, frequency of pain outbreak, average starting time of pain relief, Karnofsky functional status (KPS) score, self-rating anxiety scale (SAS) score and daily sleep time changes were compared. The serum levels of pain-causing mediators and immunoregulatory factors were monitored.  Results  The effective rate of observation group was 93.62%(44/47), which was significantly higher than that of the control group (77.78%, 35/45, P < 0.05). The NRS score of the observation group was significantly lower than that of the control group at 1 day and 1 week after treatment (all P < 0.05). After treatment, compared with the control group, the dose of oxycodone in the observation group was reduced, the number of pain bursts was less and the average time to start pain relief was significantly shortened (all P < 0.05). In the observation group, the KPS score of quality of life significantly increased, the anxiety SAS score was lower, sleep time was significantly increased, the serum pain transmitters SP and PGE2 were significantly decreased and β-EP content significantly increased (all P < 0.05). The IL-2 level in the observation group was significantly higher than that in the control group (all P < 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05).  Conclusion  Self-designed external application of cancer pain analgesia plaster combined with oxycodone hydrochloride in the treatment of refractory cancer pain is safe and effective. Its mechanism may be related to the regulation of serum substance P(SP), prostaglandin E2(PGE2), β-EP and IL-2 levels to relieve pain and enhance immune function.

     

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