Volume 20 Issue 8
Aug.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(8): 1299-1301
HATILA Tuerxun, MIKRBAN Tursun, LIU Qian, LI Jin-qiu, ALFIRA Abdujapar, AYSHAMGUL Hasim. Expression and significance of CD8+ T cells and NK cells in peripheral blood of patients with cervical cancer[J]. Chinese Journal of General Practice, 2022, 20(8): 1299-1301. doi: 10.16766/j.cnki.issn.1674-4152.002581
Citation: HATILA Tuerxun, MIKRBAN Tursun, LIU Qian, LI Jin-qiu, ALFIRA Abdujapar, AYSHAMGUL Hasim. Expression and significance of CD8+ T cells and NK cells in peripheral blood of patients with cervical cancer[J]. Chinese Journal of General Practice, 2022, 20(8): 1299-1301. doi: 10.16766/j.cnki.issn.1674-4152.002581
shu

Expression and significance of CD8+ T cells and NK cells in peripheral blood of patients with cervical cancer

doi: 10.16766/j.cnki.issn.1674-4152.002581
  • 1.

    Department of Pathology, School of Basic Medicine, Xinjiang Medical University, Xinjiang Key Laboratory of Molecular Biology for Endemic Diseases, Urumqi, Xinjiang 830054, China

Funds:

 2018D01C151

 XJ2020G186

  • Received Date: 2021-12-21
    Available Online: 2022-09-26
    Abstract
  •   Objective  To analyze the expression levels and clinical significance of natural killer cells (NK), CD8+ T cells and immune checkpoint molecules TIGIT, PD1 and PDL1 in peripheral blood of patients with cervical cancer in Xinjiang.  Methods  Fourteen cervical cancer patients and fourteen healthy people admitted to the First Affiliated Hospital of Xinjiang Medical University from September 2020 to February 2021 were divided into cervical cancer group and control group. Flow cytometry was used to detect the distribution ratio of CD8+ T cells and NK cells in peripheral blood and the expression levels of immune checkpoint molecules, TIGIT, PD1 and PDL1.  Results  The proportion of CD8+ T cells in peripheral blood of cervical cancer patients [(22.66±3.79)%] was lower than that of the control group [(28.30±8.61)%, P < 0.01], however, the proportion of NK cells in peripheral blood of cervical cancer patients has no difference compared with the control group (P>0.05). The level of PDL1 in NK cells from peripheral blood of cervical cancer patients [(5.40±4.44)%] was lower than that of the control group [(21.03±16.65)%], the difference was statistically significant (P < 0.01). However, the expression of TIGIT and PD1 in the peripheral blood of cervical cancer patient were not significantly different from those of the control group (all P>0.05). The proportions of TIGIT, PD1 and PDL1 on CD8+ T cells in peripheral blood of cervical cancer patients were not significantly different from those of the control group (P>0.05).  Conclusion  Detection of NK cells, CD8+ T cells and immune checkpoint molecules in peripheral blood of patients with cervical cancer can monitor the immune status of cervical cancer patients, which providing reference for clinical treatment.

     

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