Volume 20 Issue 8
Aug.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(8): 1384-1387
SUN Jing-wei, QI Dong, TIAN Jing-yi, DONG Nan, LIU Fang. Progress in diagnosis and treatment of Kawasaki disease with coronary artery disease in children[J]. Chinese Journal of General Practice, 2022, 20(8): 1384-1387. doi: 10.16766/j.cnki.issn.1674-4152.002603
Citation: SUN Jing-wei, QI Dong, TIAN Jing-yi, DONG Nan, LIU Fang. Progress in diagnosis and treatment of Kawasaki disease with coronary artery disease in children[J]. Chinese Journal of General Practice, 2022, 20(8): 1384-1387. doi: 10.16766/j.cnki.issn.1674-4152.002603
shu

Progress in diagnosis and treatment of Kawasaki disease with coronary artery disease in children

doi: 10.16766/j.cnki.issn.1674-4152.002603
  • 1.

    Department of Pediatrics, Bengbu First People's Hospital, Bengbu, Anhui 233000, China

Funds:

 82070513

 2020byzd372

  • Received Date: 2021-03-29
    Available Online: 2022-09-26
    Abstract
  • Kawasaki disease, or cutaneous mucocutaneous lymph node syndrome, has been reported in more than 60 countries and regions worldwide since it was first reported by doctors in Japan in 1967. Its incidence has been increasing in recent years in countries around the world. The etiology and pathogenesis of Kawasaki disease remain unclear. In general, we can assume that Kawasaki disease is a self-limiting disease with acute systemic vasculitis, mainly affecting small and medium-sized arteries, and it is prevalent in infants and children under 5 years of age. The most serious complication of Kawasaki disease is now coronary artery disease, which has replaced rheumatic fever as the main cause of acquired heart disease in children in developed countries. With the development of modern medical treatment technology, most children with Kawasaki disease can be diagnosed accurately in time. Coupled with active treatment with gammaglobulin, the incidence of Kawasaki disease combined with coronary artery lesions decreased, but eventually 2%-3% of children may still develop coronary artery stenosis, dilatation or occlusion, which can lead to myocardial infarction in severe cases. Therefore, identifying Kawasaki disease at an early stage, and detecting and intervening in Kawasaki disease combined with coronary artery lesions in time, to improve the quality of life of children and reduce the morbidity and mortality rate, has become the most noteworthy and urgent problem in the diagnosis and treatment strategy of Kawasaki disease. This article provides a review of the diagnosis and treatment of Kawasaki disease combined with coronary artery lesions to provide a reference point for pediatricians working in the clinic and for community general practitioners managing children affected by Kawasaki disease in the diagnosis and treatment of Kawasaki disease combined with coronary artery lesions.

     

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