Volume 20 Issue 9
Sep.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(9): 1473-1476
SHA Cong-wei, CHEN Wen-zheng, ZENG Mu-da, ZHOU Shi-guang, CHEN Jun-hu. Preventive effects of Galli gigerii endothelium corneum on renal calculus in rats[J]. Chinese Journal of General Practice, 2022, 20(9): 1473-1476. doi: 10.16766/j.cnki.issn.1674-4152.002626
Citation: SHA Cong-wei, CHEN Wen-zheng, ZENG Mu-da, ZHOU Shi-guang, CHEN Jun-hu. Preventive effects of Galli gigerii endothelium corneum on renal calculus in rats[J]. Chinese Journal of General Practice, 2022, 20(9): 1473-1476. doi: 10.16766/j.cnki.issn.1674-4152.002626
shu

Preventive effects of Galli gigerii endothelium corneum on renal calculus in rats

doi: 10.16766/j.cnki.issn.1674-4152.002626

  • Guangdong Provincial Institute of Biological Products and Materia Medica, Guangzhou, Guangdong 510440, China

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 20182011

 20182012

  • Received Date: 2021-09-02
    Available Online: 2022-11-29
    Abstract
  •   Objective  To study the effect of Galli gigerii endothelium corneum on kidney calcium oxalate stone in rat model, and to explore the preventive and therapeutic effect of Galli gigerii endothelium corneum on kidney calcium oxalate stone in rats.  Methods  Forty SPF male rats were randomly divided into normal group, model group, high-dose, medium-dose and low-dose groups. The normal group rats were given normal drinking water and feed, and the model group rats were given modeling agent (1% glycol water+0.2 mL / only 2% ammonium chloride to fill the stomach in the morning). The rats in high-dose (5.00 g/kg BW), medium-dose (2.50 g/kg BW), and low-dose (1.25 g/kg BW) GGEC groups fill the stomach with 0.2 mL/100 g BW at the same time in the afternoon for four weeks. The 24 h urine output, urinary calcium (Ca), urinary phosphorus content (P), and renal catalase (CAT), malondialdehyde content (MDA), serum CAT, MDA, Ca, P, creatinine (Cr), BUN contents were analyzed, and renal histopathological changes were observed at the end of the experiment.  Results  Compared with the model group, renal CAT [(6.1±1.3) U/mg vs. (4.1±1.2) U/mg, P < 0.05] and serum CAT [(29.8±1.5) U/mL vs. (26.6±1.3) U/mL, P < 0.01] significantly increased in the high-dose group, whereas renal MDA significantly decreased in the high-, medium-, and low-dose groups [(15.71±0.21) nmol/mg, (16.84±0.18) nmol/mg, (17.29±0.11) nmol/mg vs. (17.59±0.19) nmol/mg, all P < 0.01], respectively. Serum Cr [(46.5±3.3) mmol/mL vs. (52.1±2.7) mmol/mL, P < 0.01] significantly decreased in the high-dose group. Compared with the model group, the pathological damage of renal tissue in each dose group of GGEC was reduced.  Conclusion  The GGEC can effectively prevent calcium oxalate calculi and protect renal function in rats.

     

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