Volume 20 Issue 9
Sep.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(9): 1481-1483
LIU Shi-hua, ZHANG Chao, CHEN Lei, WANG Qun-feng, ZHONG Ping. Clinical value of serum VCAM-1 combined with Fazekas score in evaluating the prognosis of acute cerebral infarction with leukoaraiosis[J]. Chinese Journal of General Practice, 2022, 20(9): 1481-1483. doi: 10.16766/j.cnki.issn.1674-4152.002628
Citation: LIU Shi-hua, ZHANG Chao, CHEN Lei, WANG Qun-feng, ZHONG Ping. Clinical value of serum VCAM-1 combined with Fazekas score in evaluating the prognosis of acute cerebral infarction with leukoaraiosis[J]. Chinese Journal of General Practice, 2022, 20(9): 1481-1483. doi: 10.16766/j.cnki.issn.1674-4152.002628
shu

Clinical value of serum VCAM-1 combined with Fazekas score in evaluating the prognosis of acute cerebral infarction with leukoaraiosis

doi: 10.16766/j.cnki.issn.1674-4152.002628

  • Department of Neurology, Suzhou Hospital of Anhui Medical University, Suzhou, Anhui 234000, China

Funds:

 KJ2020A0193

 2019xkj240

  • Received Date: 2022-04-05
    Available Online: 2022-11-29
    Abstract
  •   Objective  To explore the predictive value of serum vascular cell adhesion molecule 1 (VCAM-1) level combined with Fazekas score in the clinical outcome of acute cerebral infarction with leukoaraiosis (ACIL) patients after 90 days.  Methods  A total of 96 acute cerebral infarction patients with an National Institutes of Health Stroke Scale (NIHSS) score of 8 who were admitted to the Suzhou Hospital Affiliated to Anhui Medical University from August 2020 to October 2021 were selected as the research objects. Enzyme-linked immunosorbent assay was used to detect serum VCAM-1 levels, and Fazekas score was determined for all patients according to brain magnetic resonance. Based on the modified Rankin scale (mRS), the prognosis of patients at 90 days was evaluated. mRS≤2 was regarded as good prognosis (70 cases), and mRS≥3 was regarded as poor prognosis (26 cases). The receiver operating characteristic (ROC) curve was used to analyse the value of serum VCAM-1 level combined with Fazekas score in evaluating the prognosis of ACIL patients.  Results  Compared with the good-prognosis group, the age [(71.23±3.66) years vs. (64.57±5.24) years], serum VCAM-1 level [2.66 (2.48, 2.78) ng/mL vs. 2.10 (1.40, 2.23) ng/mL], and Fazekas score [4 (4, 5) points vs. 3 (2, 3) points] of the poor-prognosis group were significantly higher than those in the good-prognosis group (all P < 0.05). Multivariate logistic-regression analysis showed that age, VCAM-1 level and Fazekas score were independent risk factors for poor prognosis. ROC curve analysis results revealed that the sensitivity and specificity of poor prognosis assessment were 92.31% and 94.29%, respectively.  Conclusion  Serum VCAM-1 combined with Fazekas score has a high predictive value for the 90-day outcome of acute cerebral infarction patients.

     

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