Effect of platelet-rich plasma combined with sodium hyaluronate in the treatment of knee osteoarthritis

SU Hong-nian; SIMA Liang-jie; YANG Mu-qiang; XI Li-feng

doi:10.16766/j.cnki.issn.1674-4152.002636

Volume 20 Issue 9

Sep. 2022

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Article Navigation > Chinese Journal of General Practice > 2022 > 20(9): 1509-1512

SU Hong-nian, SIMA Liang-jie, YANG Mu-qiang, XI Li-feng. Effect of platelet-rich plasma combined with sodium hyaluronate in the treatment of knee osteoarthritis[J]. Chinese Journal of General Practice, 2022, 20(9): 1509-1512. doi: 10.16766/j.cnki.issn.1674-4152.002636

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SU Hong-nian, SIMA Liang-jie, YANG Mu-qiang, XI Li-feng. Effect of platelet-rich plasma combined with sodium hyaluronate in the treatment of knee osteoarthritis[J]. Chinese Journal of General Practice, 2022, 20(9): 1509-1512. doi: 10.16766/j.cnki.issn.1674-4152.002636

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Effect of platelet-rich plasma combined with sodium hyaluronate in the treatment of knee osteoarthritis

doi: 10.16766/j.cnki.issn.1674-4152.002636

1.
Department of Pain, the First Affiliated Hospital of Henan University of Science and Technology, Luoyang, Henan 471003, China

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LHGJ20191445

Received Date: 2021-04-28
Available Online: 2022-11-29

Abstract

Abstract

Objective To investigate the effect of injection of platelet-rich plasma and sodium hyaluronate on knee osteoarthritis (KOA). Methods A total of 120 patients admitted in the First Affiliated Hospital of Henan University of Science and Technology from June 2018 to February 2020 was selected. The random number table was used to group patients: 60 patients with foundation treatment + knee joint injection of sodium hyaluronate (conventional group) comprised one group, and 60 patients with use of platelet rich plasma treatment on the basis of routine treatment group (study group) comprised the other group. The changes in regulatory complex factor 1α mRNA and silencing information regulator 1 in chondrocytes mRNA in knee joint fluid and other factors were compared before and after treatment. Results After treatment, the knee swelling score of the study group was (1.83±0.51) points and the pain score of the study group was (2.87±0.98) points, which were lower than those of the conventional group (2.28±0.65) points and (3.31±1.20) points; the differences were statistically significant (all P < 0.05). After treatment, the mRNA expression intensity of ASF1α in the study group was 0.58±0.17, which was lower than that in the conventional group (0.71±0.21, P < 0.05). The mRNA expression levels of SIRT1 and superoxide dismutase in the study group were 1.41±0.30 and (124.9±28.0) U/L, respectively, which were higher than those in the conventional group [1.22±0.28 and (113.8±24.1) U/L, all P < 0.05]. After treatment, the Lysholm score of the study group was (69.84±11.03) points, which was higher than that of the conventional group [(65.28±12.26) points, P < 0.05]. The total effective rate of the study group was 98.33%, which was higher than 85.00% of the conventional group (P < 0.05). Conclusion Injection of platelet-rich plasma and sodium hyaluronate in KOA patients can effectively regulate the levels of ASF1α mRNA, SIRT1 mRNA and SOD in the joint fluid, and it has a significant effect on the recovery of joint function and relief of clinical symptoms.
- Platelet-rich plasma,
- Sodium hyaluronate,
- Knee osteoarthritis,
- Synovial fluid,
- Silencing information regulator 1 in chondrocytes,
- Regulatory complex factor 1α

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References(21)

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Effect of platelet-rich plasma combined with sodium hyaluronate in the treatment of knee osteoarthritis

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