Volume 20 Issue 9
Sep.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(9): 1628-1630
WU Zeng-xiang, AN Kang, LI Shuang-qing. Metagenomics next generation sequencing assisted diagnosis of visceral leishmaniasis: A case report and literature review[J]. Chinese Journal of General Practice, 2022, 20(9): 1628-1630. doi: 10.16766/j.cnki.issn.1674-4152.002665
Citation: WU Zeng-xiang, AN Kang, LI Shuang-qing. Metagenomics next generation sequencing assisted diagnosis of visceral leishmaniasis: A case report and literature review[J]. Chinese Journal of General Practice, 2022, 20(9): 1628-1630. doi: 10.16766/j.cnki.issn.1674-4152.002665
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Metagenomics next generation sequencing assisted diagnosis of visceral leishmaniasis: A case report and literature review

doi: 10.16766/j.cnki.issn.1674-4152.002665

  • General Practice Center, West China Hospital, Sichuan University, Chengdu, 610041, China

  • Received Date: 2022-02-15
    Available Online: 2022-11-29
    Abstract
  • Metagenomics next generation sequencing (mNGS) has the advantage of rapid detection of a wide range of pathogens. A case of visceral leishmaniasis (VL) was reported. The patient, a 47-year-old male, started with recurrent fever and went to several hospitals without definite diagnosis. He was treated with antibacterial agents and symptomatic treatment, but his condition was not relieved. After that, the Leishmania sequences were found by mNGS, and rK39 immunochromatographic rapid detection (rK39 test) was further performed. The result was positive, and the final diagnosis was visceral leishmaniasis. It is suggested that mNGS is expected to be used in the diagnosis of visceral leishmaniasis, and it has important reference value in the diagnosis of infectious diseases.

     

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