Volume 20 Issue 10
Oct.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(10): 1672-1674
LIAO Qiu-lin, LAI Xu-wen, WU Xiao-li, HAN Li-fang, PENG Da-yun, ZHUANG Jie-na, LIAO Yue-yuan. Expression and significance of annexin A1 and S100A16 protein in human glioma[J]. Chinese Journal of General Practice, 2022, 20(10): 1672-1674. doi: 10.16766/j.cnki.issn.1674-4152.002675
Citation: LIAO Qiu-lin, LAI Xu-wen, WU Xiao-li, HAN Li-fang, PENG Da-yun, ZHUANG Jie-na, LIAO Yue-yuan. Expression and significance of annexin A1 and S100A16 protein in human glioma[J]. Chinese Journal of General Practice, 2022, 20(10): 1672-1674. doi: 10.16766/j.cnki.issn.1674-4152.002675
shu

Expression and significance of annexin A1 and S100A16 protein in human glioma

doi: 10.16766/j.cnki.issn.1674-4152.002675
  • 1.

    Department of Pathology, Guangdong Clifford Hospital, Guangzhou, Guangdong 511495, China

Funds:

 A2019320

  • Received Date: 2021-08-03
    Available Online: 2022-11-30
    Abstract
  •   Objective   To investigate the expression level and significance of annexin A1 (ANXA1) and S100A16 protein in glioma.   Methods   A total of 160 glioma cases and 20 dysembryoplastic neuroepithelial tumor (DNT) cases confirmed by Guangdong Clifford Hospital and General Hospital of Southern Theater Command from January 2015 to December 2020 were collected. The expression levels of ANXA1 and S100A16 proteins were detected by immunohistochemistry (IHC).   Results   The detectable rate of ANXA1 in glioma group was 80.6% (129/160), which was higher than that in normal brain tissue by 7.5% (12/160). The detectable rate of S100A16 in the glioma group was 86.3% (138/160), which was higher than that in the normal brain tissue group by 10.0% (19/160). No significant difference in the detectable rates of ANXA1 and S100A16 was found in the WHO grade Ⅰ-Ⅳ gliomas. The detectable rate of annexin A1 in astrocytoma without WHO grade Ⅰ was the highest, reaching 95.0% (76/80), which was much higher than that in oligodendroglioma (42.9%, 15/35). The detectable rate of S100A16 in astrocytoma without WHO grade Ⅰ (83.8%, 67/80) was not statistically significant compared with that in oligodendroglioma (88.6%, 31/35). Significant difference in the detectable rate of ANXA1 was found between the DNT group (100.0%, 20/20) and low-grade glioma group (78.8%, 63/80).   Conclusion   ANXA1 can be used as an auxiliary diagnostic marker for glioma and for the differential diagnosis of complex DNT and oligodendroglioma. Statisical difference in the expression of S100A16 differed between glioma and normal brain tissue, but S100A16 cannot be used as an auxiliary marker in the differential diagnosis of DNT and low-grade glioma.

     

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