Volume 20 Issue 10
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(10): 1746-1750
LI Han-yue, DING Shi-tian, CHEN Xiao-qing. Research progress of respiratory microbiota and lung disease in neonates[J]. Chinese Journal of General Practice, 2022, 20(10): 1746-1750. doi: 10.16766/j.cnki.issn.1674-4152.002694
Citation: LI Han-yue, DING Shi-tian, CHEN Xiao-qing. Research progress of respiratory microbiota and lung disease in neonates[J]. Chinese Journal of General Practice, 2022, 20(10): 1746-1750. doi: 10.16766/j.cnki.issn.1674-4152.002694
shu

Research progress of respiratory microbiota and lung disease in neonates

doi: 10.16766/j.cnki.issn.1674-4152.002694
  • 1.

    Collage of Nursing, Nanjing Medical University, Nanjing, Jiangsu 211166, China

Funds:

 81871195

  • Received Date: 2021-12-25
    Available Online: 2022-11-30
    Abstract
  • The neonatal period is the key period for the establishment of stable physiological function between the microbiota and the host. During this period, the number of respiratory microbiota increases, and the species changes from single to diversified. Progress in neonatal respiratory tract specimen collection technology and microecological monitoring technology has broken the original technical "barrier". The progress in specimen extraction technology and improved detection technology accuracy have increased the credibility of microecological research and offered convenience for clinical research. In the neonatal respiratory tract, the decreased abundance of beneficial bacteria, such as Moraxella, Corynebacterium and Dolosigranulum, the increased proportion of potential pathogenic bacteria, such as Pseudomonas aeruginosa, Haemophilus influenzae and Staphylococcus aureus, and the change in bacterial diversity were closely related to the occurrence and development of respiratory diseases, such as bronchopulmonary dysplasia, asthma, cystic fibrosis and pneumonia. The establishment and evolution of neonatal respiratory flora are regulated by many factors, such as delivery mode, feeding mode, use of antibiotics, gestational age, birth date and age. Research from the perspective of microorganisms can clarify the action mechanism of respiratory microorganisms in neonatal respiratory diseases, open up a new perspective for disease prevention and treatment and achieve the purpose of accurate treatment. This paper reviews the influencing factors of neonatal respiratory tract microbiota, the relationship between intestinal microbiota and respiratory diseases.

     

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