Volume 20 Issue 12
Dec.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(12): 2045-2049
GUAN Ting, ZHANG Yue, ZHANG Dong-mei, YANG Juan, MA Xu, ZHAO Jun. Association of low glucose-6-phosphate dehydrogenase enzyme activity with hepatitis B virus infection in adult males[J]. Chinese Journal of General Practice, 2022, 20(12): 2045-2049. doi: 10.16766/j.cnki.issn.1674-4152.002766
Citation: GUAN Ting, ZHANG Yue, ZHANG Dong-mei, YANG Juan, MA Xu, ZHAO Jun. Association of low glucose-6-phosphate dehydrogenase enzyme activity with hepatitis B virus infection in adult males[J]. Chinese Journal of General Practice, 2022, 20(12): 2045-2049. doi: 10.16766/j.cnki.issn.1674-4152.002766
shu

Association of low glucose-6-phosphate dehydrogenase enzyme activity with hepatitis B virus infection in adult males

doi: 10.16766/j.cnki.issn.1674-4152.002766
  • 1.

    Shenzhen Health Development Research Center, Shenzhen, Guangdong 518028, China

Funds:

 2016YFC1000307

 2018NRIFPJ03

  • Received Date: 2021-12-11
    Available Online: 2023-02-07
    Abstract
  •   Objective  To investigate the association between low glucose-6-phosphate dehydrogenase (G6PD) enzyme activity and hepatitis B virus (HBV) infection in adult males.  Methods  A case-control study was conducted on 85 286 adult males who participated in the National Free Pre-conception Health Checkup Project in Shenzhen from January 2013 to December 2019 and met the inclusion and exclusion criteria. The relationship between low G6PD enzyme activity and HBV infection was analysed by multivariate logistic regression models, and their influence on glutamic-pyruvic transaminase (ALT) elevation was observed.  Results  Adult males with a low G6PD enzyme activity had a 20.4% (OR=1.204, P < 0.001) increased risk of HBV infection compared with those with non-low G6PD enzyme activity. Compared with adult males without low G6PD enzyme activity and without HBV infection, those with HBV infection alone had a 60.3% (OR=1.603, P < 0.001) and 123.8% (OR=2.238, P < 0.001) increased risk of mild and moderate/severe elevation of ALT, respectively. Meanwhile, those with combined low G6PD enzyme activity and HBV infection had 69.3% (OR=1.693, P < 0.001) and 190.2% (OR=2.902, P < 0.001) increased risk of mild and moderate/severe elevation of ALT, respectively.  Conclusion  Adult males with a low G6PD enzyme activity will increase the risk of HBV infection, and increase the risk of elevated ALT in HBV-infected individuals. In the case of adult males with a low G6PD enzyme activity and HBV infection, the collaborative management method of the two diseases must be explored for clinical settings.

     

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