Volume 20 Issue 12
Dec.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(12): 2055-2058
WANG Ying, YUN Chun-mei, LIU Ke-han, JIA Pei-feng, LIU Hong-yan, GAO Xiao-yu. Clinical characteristic analysis of different inflammatory phenotypes in bronchial asthma[J]. Chinese Journal of General Practice, 2022, 20(12): 2055-2058. doi: 10.16766/j.cnki.issn.1674-4152.002768
Citation: WANG Ying, YUN Chun-mei, LIU Ke-han, JIA Pei-feng, LIU Hong-yan, GAO Xiao-yu. Clinical characteristic analysis of different inflammatory phenotypes in bronchial asthma[J]. Chinese Journal of General Practice, 2022, 20(12): 2055-2058. doi: 10.16766/j.cnki.issn.1674-4152.002768
shu

Clinical characteristic analysis of different inflammatory phenotypes in bronchial asthma

doi: 10.16766/j.cnki.issn.1674-4152.002768

  • Department of Pulmonary and Critical Care Medicine, Inner Mongolia People' s Hospital/National Key Laboratory for Diagnosis and Treatment of Chronic Obstructive Pulmonary Disease/Inner Mongolia Autonomous Region Key Laboratory of Respiratory Diseases, Huhhot, Inner Mongolia 010017, China

Funds:

 201802161

 201703

 2019BS08

 2021MS08165

 2021MS08112

  • Received Date: 2021-03-18
    Available Online: 2023-02-07
    Abstract
  •   Objective  To analyse the clinical characteristics of different inflammatory phenotypes of bronchial asthma (BA) and compare the clinical indicators before and after treatment, so as to provide a basis for clinical diagnosis and treatment of asthma.  Methods  A total of 110 asthma patients in chronic duration in the Outpatient Ward of Inner Mongolia People ' s Hospital were recruited from July 2018 to January 2019, and divided into four groups with different airway inflammation phenotypes based on the results of induced sputum, such as eosinophilic asthma (EA), neutrophilic asthma, mixed granulocytic asthma (MGA) and paucigranulocytic asthma. The differences in clinical characteristics were compared, and the clinical indicators before and after treatment were compared and analysed.  Results  No significant differences were observed in the clinical symptoms and control level between inflammatory phenotypes (both P>0.05). Compared with the other groups, the EA group showed a significantly increased exhaled nitric oxide (FeNO) and significantly decreased FEV1 /FVC and FEV1 % (all P < 0.05). The number of eosinophil (Eos) was positively correlated trend with the values of FeNO (r=0.541), and negatively correlated with the values of FEV1 /FVC and FEV1 % (r=-0.301, -0.284). The clinical indicators of asthma before treatment and 1 month after treatment (low-dose inhale corticosteroids+long-acting inhale β2-agonist) were compared. The Eos and FeNO in EA and MGA groups significantly decreased after treatment compared with those before treatment (EA: t=3.564, 6.761; MGA: t=3.068, 4.093, all P < 0.05). FEV1 /FVC and FEV1 % in the EA group were significantly higher than those before treatment (t=-2.755, -2.729, both P < 0.05).  Conclusion  Lung function decline is pronounced in the Eos-increased phenotype (EA), and FeNO is closely associated with eosinophilic inflammation. Low-dose ICS+LABA is effective in Eos-increasing phenotype asthma patients.

     

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