Volume 20 Issue 12
Dec.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(12): 2101-2104
HUANG Hong, XU Bao-cai. Study on the magnetic resonance colonography combined with fecal calprotectin in the diagnosis of ulcerative colitis[J]. Chinese Journal of General Practice, 2022, 20(12): 2101-2104. doi: 10.16766/j.cnki.issn.1674-4152.002779
Citation: HUANG Hong, XU Bao-cai. Study on the magnetic resonance colonography combined with fecal calprotectin in the diagnosis of ulcerative colitis[J]. Chinese Journal of General Practice, 2022, 20(12): 2101-2104. doi: 10.16766/j.cnki.issn.1674-4152.002779
shu

Study on the magnetic resonance colonography combined with fecal calprotectin in the diagnosis of ulcerative colitis

doi: 10.16766/j.cnki.issn.1674-4152.002779
  • 1.

    Department of Radiology, Quzhou Hospital of Traditional Chinese Medicine, Quzhou, Zhejiang 324002, China

Funds:

 2021ZB327

  • Received Date: 2022-08-29
    Available Online: 2023-02-07
    Abstract
  •   Objective  To observe the clinical value of magnetic resonance colonography (MRC) combined with fecal calprotectin (FC) in the diagnosis and evaluation of ulcerative colitis (UC).  Methods  A total of 80 UC patients and 80 healthy subjects during the same period admitted to Quzhou Hospital of Traditional Chinese Medicine from June 2019 to June 2022 were selected as the research objects. All the subjects were examined by colonoscopy, MRC and FC. The MRC image characteristics and FC content of UC patients with different activity levels and healthy subjects were compared. The results of colonoscopy were used as the gold standard to evaluate the efficacy of MRC imaging feature score, FC content and their combination in the diagnosis of UC.  Results  There were statistically significant differences in the proportions of MRC imaging features such as mucosal enhancement, intestinal wall thickening, intestinal wall layering enhancement, comb tooth sign, intestinal wall lymph node enlargement, mucosal and submucosal defects and DWI signal enhancement in healthy subjects and UC patients with different activity levels (all P < 0.05), and there were statistically significant differences in the proportion of MRC imaging features such as intestinal wall stratification enhancement, comb tooth sign, intestinal wall lymph node enlargement in UC patients with different activity levels (P < 0.05). The difference of FC content between healthy subjects and UC patients with different activity levels was statistically significant (P < 0.01). The FC content of UC patients was (3 186.11±291.80) μg/g, significantly higher than that of healthy subjects [(2 699.47±249.67) μg/g, P < 0.05], while the FC content in UC patients with different activity levels was not statistically significant (P>0.05). The area under the ROC curve of MRC image feature score, FC content and MRC image feature score combined with FC content in diagnosing UC were 0.956, 0.895 and 0.984, respectively.  Conclusion  MRC and FC, as two non-invasive diagnostic techniques, can be used as an alternative or auxiliary means of colonoscopy pathology for UC diagnosis and disease evaluation. The combined application of MRC and FC can improve the diagnostic efficiency of UC.

     

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