Advances in pathogenesis of protein disulfide isomerase in thrombotic disease

WANG Li-yao; WANG Bing-kun; LI Wen; A-RI-FU A-yi-mai-li-ka; BAI Tian-yu; XU Meng; SU Li-bo

doi:10.16766/j.cnki.issn.1674-4152.002782

Volume 20 Issue 12

Dec. 2022

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Article Navigation > Chinese Journal of General Practice > 2022 > 20(12): 2114-2118

WANG Li-yao, WANG Bing-kun, LI Wen, A-RI-FU A-yi-mai-li-ka, BAI Tian-yu, XU Meng, SU Li-bo. Advances in pathogenesis of protein disulfide isomerase in thrombotic disease[J]. Chinese Journal of General Practice, 2022, 20(12): 2114-2118. doi: 10.16766/j.cnki.issn.1674-4152.002782

Citation:

WANG Li-yao, WANG Bing-kun, LI Wen, A-RI-FU A-yi-mai-li-ka, BAI Tian-yu, XU Meng, SU Li-bo. Advances in pathogenesis of protein disulfide isomerase in thrombotic disease[J]. Chinese Journal of General Practice, 2022, 20(12): 2114-2118. doi: 10.16766/j.cnki.issn.1674-4152.002782

Citation:

WANG Li-yao, WANG Bing-kun, LI Wen, A-RI-FU A-yi-mai-li-ka, BAI Tian-yu, XU Meng, SU Li-bo. Advances in pathogenesis of protein disulfide isomerase in thrombotic disease[J]. Chinese Journal of General Practice, 2022, 20(12): 2114-2118. doi: 10.16766/j.cnki.issn.1674-4152.002782

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Advances in pathogenesis of protein disulfide isomerase in thrombotic disease

doi: 10.16766/j.cnki.issn.1674-4152.002782

1.
Department of Laboratory Animal, Hebei Medical University, Shijiazhuang, Hebei 050017, China

Funds:

BJ2019026

Received Date: 2022-06-08
Available Online: 2023-02-07

Abstract

Abstract

Protein disulfide isomerase (PDI), the prototypical member of the PDI family, is encoded by the prolyl 4-hydroxylase subunit beta (P4HB) gene and is the β subunit of the P4H protein, so it is also called P4HB. It is mainly found in the endoplasmic reticulum (ER) and plays an important role in pathophysiological processes by promoting correct protein folding through enzymatic activity and molecular chaperone function. Related studies on PDI in China and abroad have explored the mechanisms of action in diseases, such as cancer and neurodegenerative diseases. In addition to its key role in ER, the role of cell surface PDI in initiating the thrombosis process is particularly prominent. PDI can be rapidly secreted from activated platelets and endothelial cells at the site of vascular injury to promote platelet activation and fibrin formation and mediate the activation of coagulation factor, its release and the coagulation pathway. Inhibition of PDI with antibodies or small-molecule inhibitors may prevent thrombosis. Given the important role of extracellular PDI in the regulation of thrombosis, scholars should aim to understand the pathogenic mechanism of PDI thrombotic disease. Efforts are ongoing to identify extracellular PDI substrates that participate in the network pathway between PDI and thrombosis. In this paper, we summarise our current understanding of the mechanism of PDI-mediated thrombosis, discusses the research progress in blocking thrombosis by targeted PDI and provide new ideas for further exploration of the application of this substance in the prevention and treatment of thrombotic diseases.
- Protein disulfide isomerase,
- Thrombosis,
- Prolyl 4-hydroxylase subunit beta,
- Pathogenesis of the disease

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References(40)

References

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