Volume 21 Issue 1
Jan.  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(1): 45-49
WANG Hong, WANG Liu-qing, ZHANG Wan-li, WANG Zhen, YE Zu-sen, CHENG Yi-fan, HUANG Huan-jie, SHAO Bei. Relationship between time of intravenous thrombolysis and early cognitive function in patients with acute mild ischemic stroke and transient ischemic attack[J]. Chinese Journal of General Practice, 2023, 21(1): 45-49. doi: 10.16766/j.cnki.issn.1674-4152.002808
Citation: WANG Hong, WANG Liu-qing, ZHANG Wan-li, WANG Zhen, YE Zu-sen, CHENG Yi-fan, HUANG Huan-jie, SHAO Bei. Relationship between time of intravenous thrombolysis and early cognitive function in patients with acute mild ischemic stroke and transient ischemic attack[J]. Chinese Journal of General Practice, 2023, 21(1): 45-49. doi: 10.16766/j.cnki.issn.1674-4152.002808
shu

Relationship between time of intravenous thrombolysis and early cognitive function in patients with acute mild ischemic stroke and transient ischemic attack

doi: 10.16766/j.cnki.issn.1674-4152.002808
  • 1.

    Department of Neurology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China

Funds:

 LY19H090013

 2020KY637

 2017Y0911

  • Received Date: 2022-02-04
    Available Online: 2023-04-07
    Abstract
  •   Objective  To investigate the influence of intravenous thrombolytic time on early cognitive function in patients with acute mild ischemic stroke (MIS), and transient ischemic attack (TIA).  Methods  A total of 173 MIS and TIA patients (The National Institutes of Health Stroke, NIHSS ≤6) who were admitted to the First Affiliated Hospital of Wenzhou Medical University between January 2017 and December 2019 were collected. These patients received intravenous thrombolytic therapy within 4.5 hours of onset. A total of 156 cases were finally included in the study. According to whether the patients had cognitive dysfunction 30 days after the onset of the disease, they were divided into cognitive impairment group (n=100) and non-cognitive impairment group (n=56). The baseline characteristics, intravenous thrombolytic time and the occurrence of cognitive impairment of the two groups were summarized, and the impact of intravenous thrombolytic time on the occurrence of early cognitive impairment was analyzed.  Results  The age of cognitive impairment group was significantly higher than that of non-cognitive impairment group (P=0.037); the educational time was significantly shorter than that of non-cognitive impairment group (P=0.011); the course of hypertension and diabetes, intravenous thrombolysis time was significantly longer than the non-cognitive impairment group (P=0.036, 0.003, 0.017); the cognitive impairment group had significantly higher total cholesterol than the non-cognitive impairment group (P=0.040). Logistic regression showed that older age (OR=1.092, 95% CI: 1.031-1.157, P=0.002), longer duration of hypertension (OR=1.238, 95% CI: 1.002-1.193, P=0.021), longer duration of diabetes (OR=1.265, 95% CI: 1.116-1.384, P=0.016), and longer duration of intravenous thrombolysis(OR=1.105, 95% CI: 1.067-1.356, P=0.010) were associated with cognitive impairment 30 days after intravenous thrombolysis independent risk factors.  Conclusion  Shortening the time of intravenous thrombolysis after onset may help reduce patient' early cognitive impairment in patients with acute mild ischemic stroke, and transient ischemic attack.

     

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