Volume 21 Issue 2
Feb.  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(2): 207-209
WANG Zi-cheng, QI Yin-liang, XU Ji-xiang, LI Wei, ZHOU Xiao-mei. Effects of hyperbaric oxygen combined with Xingnaojing injection on the consciousness improvement and serum SOD and NO in comatose patients with traumatic brain injury[J]. Chinese Journal of General Practice, 2023, 21(2): 207-209. doi: 10.16766/j.cnki.issn.1674-4152.002846
Citation: WANG Zi-cheng, QI Yin-liang, XU Ji-xiang, LI Wei, ZHOU Xiao-mei. Effects of hyperbaric oxygen combined with Xingnaojing injection on the consciousness improvement and serum SOD and NO in comatose patients with traumatic brain injury[J]. Chinese Journal of General Practice, 2023, 21(2): 207-209. doi: 10.16766/j.cnki.issn.1674-4152.002846
shu

Effects of hyperbaric oxygen combined with Xingnaojing injection on the consciousness improvement and serum SOD and NO in comatose patients with traumatic brain injury

doi: 10.16766/j.cnki.issn.1674-4152.002846
  • 1.

    Graduate School of Bengbu Medical College, Bengbu, Anhui 233030, China

Funds:

 2020byzd309

 2020b07030008

 202234-4

  • Received Date: 2022-08-05
    Abstract
  •   Objective  This study aims to investigate the effects of two therapeutic methods of Xingnaojing injection alone and hyperbaric oxygen combined with Xingnaojing injection on the improvement of consciousness and the levels of SOD and NO in serum of patients with coma caused by traumatic brain injury (TBI).  Methods  The clinical data of 56 patients with severe TBI coma who were treated in the hyperbaric oxygen department and neurosurgery department of Hefei Second People ' s Hospital from May 1, 2021 to January 31, 2022 were collected by retrospective investigation. The patients were divided into the hyperbaric oxygen treatment group (observation group) and non-hyperbaric oxygen treatment group (control group) based on whether they received hyperbaric oxygen treatment during the hospital period, including 32 patients in the observation group and 24 patients in the control group. The Glasgow coma scale (GCS) was used to assess and record the consciousness status in the two groups of patients before and after treatment. The levels of serum superoxide dismutase (SOD) and nitric oxide (NO) were measured before treatment, on the 10th and 20th days of treatment in 2 groups, meantime, the recovery rate of patients was recorded.  Results  The GCS score of the two groups after treatment was higher than that before treatment (all P < 0.05). The GCS score of the observation group after treatment increased to (9.22±2.27) points, which was significantly higher than that of the control group after treatment [(7.71±2.77) points, P < 0.05]. The recovery rate of the observation group [59.4% (19/32)] was significantly higher than that of the control group [29.2% (7/24), P < 0.05]. The SOD level of the two groups increased sequentially before treatment, on the 10th and 20th days of treatment. While, the NO level of the two groups decreased sequentially before treatment, on the 10th and 20th days of treatment.  Conclusion  Hyperbaric oxygen combined with Xingnaojing injection can significantly improve the consciousness of patients with coma caused by traumatic brain injury, and increase the recovery rate. Furthermore, its possible mechanism is related to the increase of serum SOD level and the decrease of serum NO level.

     

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