Volume 21 Issue 2
Feb.  2023
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YANG Jian-hua, LI Xue, LIU Hao. Efficacy of serum sTREM-1 combined with SIRS score in the diagnosis of sepsis in burn patients[J]. Chinese Journal of General Practice, 2023, 21(2): 234-237. doi: 10.16766/j.cnki.issn.1674-4152.002853
Citation: YANG Jian-hua, LI Xue, LIU Hao. Efficacy of serum sTREM-1 combined with SIRS score in the diagnosis of sepsis in burn patients[J]. Chinese Journal of General Practice, 2023, 21(2): 234-237. doi: 10.16766/j.cnki.issn.1674-4152.002853
shu

Efficacy of serum sTREM-1 combined with SIRS score in the diagnosis of sepsis in burn patients

doi: 10.16766/j.cnki.issn.1674-4152.002853
  • 1.

    Hand Foot Trauma and Wound Repair Surgery, Shandong Provincial Third Hospital, Jinan, Shandong 253500, China

Funds:

 2017WS1019

  • Received Date: 2022-01-29
    Available Online: 2023-04-20
    Abstract
  •   Objective  To explore the changes of serum soluble medullary cell trigger receptor 1 (sTREM-1) and systemic inflammatory response syndrome (SIRS) scores in burn patients, and the diagnostic value of the two indexes in burn patients complicated with sepsis.  Methods  A total of 193 burn patients admitted to Shandong Provincial Third Hospital from March 2019 to October 2020 were selected, including 65 cases of local infection (local infection group), 38 cases of sepsis (sepsis group), and 90 cases of simple burn (simple burns group). Serum sTREM-1 level was detected and SIRS score was performed. The value of sTREM-1 combined with SIRS score in diagnosing burn complicated sepsis was analyzed by receiver operating characteristic curve (ROC).  Results  Serum sTREM-1 level [(169.83±31.54) ng/mL, (124.05±24.09) ng/mL, (72.18±11.58) ng/mL] and SIRS score [3.5 (2.0, 4.0) vs, 1.5(1.0, 2.0), 0.5(0, 1.0)] in the sepsis group were higher than those in the local infection group and the Simple burns group (P < 0.05), and serum sTREM-1 level and SIRS score in the local infection group were higher than those in the simple burns group (P < 0.05). Logistic regression analysis showed that high sTREM-1 level (OR=2.003, 95% CI: 1.945-2.135) was a risk factor for sepsis in burn patients (P < 0.05). ROC analysis showed that the AUC of sTREM-1, SIRS score, combined sTREM-1 and SIRS score in the diagnosis of burn patients with sepsis were 0.731, 0.629 and 0.943, respectively, and the combined diagnosis was higher than that of sTREM-1 and SIRS score alone (P < 0.05).  Conclusion  sTREM-1 and SIRS score have certain value in the diagnosis of sepsis in burn patients, and the combination of the two indexes can improve the diagnostic efficiency.

     

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