Volume 21 Issue 2
Feb.  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(2): 242-246
LI Ya-nan, WAN Zheng-zuo, LI Yan-yan, JUE Bin, YU Xue-lai, WANG Li-feng. Application effect of acupoint electrical stimulation combined with general anesthesia in elderly patients undergoing laparoscopic radical resection of colorectal cancer[J]. Chinese Journal of General Practice, 2023, 21(2): 242-246. doi: 10.16766/j.cnki.issn.1674-4152.002855
Citation: LI Ya-nan, WAN Zheng-zuo, LI Yan-yan, JUE Bin, YU Xue-lai, WANG Li-feng. Application effect of acupoint electrical stimulation combined with general anesthesia in elderly patients undergoing laparoscopic radical resection of colorectal cancer[J]. Chinese Journal of General Practice, 2023, 21(2): 242-246. doi: 10.16766/j.cnki.issn.1674-4152.002855
shu

Application effect of acupoint electrical stimulation combined with general anesthesia in elderly patients undergoing laparoscopic radical resection of colorectal cancer

doi: 10.16766/j.cnki.issn.1674-4152.002855

  • Anesthesiology Department, Hangzhou Hospital of Traditional Chinese Medical, Hangzhou, Zhejiang 321000, China

Funds:

 20181228Y29

 2020ZB155

 20201203B202

  • Received Date: 2022-08-29
    Available Online: 2023-04-20
    Abstract
  •   Objective  To analyze the effects of transcutaneous electrical acupoint stimulation (TEAS) combined with general anesthesia on gastrointestinal hormones and postoperative cognitive dysfunction (POCD), and investigate the effect of TEAS combined with general anesthesia in elderly patients after laparoscopic radical resection of colorectal cancer.  Methods  A total of 90 elderly patients who underwent laparoscopic radical resection of colorectal cancer in Hangzhou Hospital of Traditional Chinese Medical from January 2020 to January 2022 were selected and divided into A and B group by random number table method, with 45 cases in each group. Patients in the group A were given general anesthesia treatment, and patients in the group B were given TEAS on the basis of the group A. The perioperative indicators, hemodynamic changes at different time during operation, gastrointestinal hormone levels, central nervous specific (S100β) protein and brain derived neurotrophic factor (BDNF) levels, mini-mental state examination (MMSE) scores, and the occurrence of POCD were compared between the two groups.  Results  The dosage of propofol and remifentanil, awakening time and extubation time of the group B were significantly lower than those in the group A (P < 0.05). The level of central venous pressure (CVP) in the group B was significantly higher than that in the group A (P < 0.05). The levels of gastrin (GAS) and motilin (MTL) in both groups were significantly lower than those before surgery (P < 0.05), and the group B was significantly higher than the group A (all P < 0.05). The S100β level protein was firstly increased and then decreased (P < 0.05), and BDNF level and MMSE score were firstly decreased and then increased (all P < 0.05). The levels of S100β protein in the group B were lower than those in the group A on 1 d, 3 d and 7 d after surgery (all P < 0.05), the levels of BDNF and MMSE score were higher than those in the group A (all P < 0.05). The occurrence of POCD in the group B on 1 d and 3 d after surgery were significantly lower than those in the group A (37.78% vs. 68.89%, 24.44% vs. 51.11%, all P < 0.05).  Conclusion  TEAS combined with general anesthesia can alleviate the inhibitory effect of surgery and anesthesia on gastrointestinal hormone secretion, protect the central nervous system, improve cognitive function, and reduce the occurrence of POCD in elderly patients after laparoscopic radical colorectal cancer surgery.

     

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