Volume 21 Issue 4
Apr.  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(4): 677-680
YANG Yanqing, RUI Rong, WU Pengtao, LI Ying, ZHENG Qinghu, LI Da, TAO Ying, WU Tianxin, ZHOU Lihong. Clinical effect of Xiaoxun Huazhuo Recipe on colorectal polyps with metabolic syndrome and influencing factors[J]. Chinese Journal of General Practice, 2023, 21(4): 677-680. doi: 10.16766/j.cnki.issn.1674-4152.002958
Citation: YANG Yanqing, RUI Rong, WU Pengtao, LI Ying, ZHENG Qinghu, LI Da, TAO Ying, WU Tianxin, ZHOU Lihong. Clinical effect of Xiaoxun Huazhuo Recipe on colorectal polyps with metabolic syndrome and influencing factors[J]. Chinese Journal of General Practice, 2023, 21(4): 677-680. doi: 10.16766/j.cnki.issn.1674-4152.002958
shu

Clinical effect of Xiaoxun Huazhuo Recipe on colorectal polyps with metabolic syndrome and influencing factors

doi: 10.16766/j.cnki.issn.1674-4152.002958
  • 1.

    Department of Traditional Chinese Medicine, Shanghai Puxing Community Health Center, Pudong New District, Shanghai 200129, China

Funds:

 81973651

 82174145

 PWRzs-2020-02

 PKJ-Y56

  • Received Date: 2022-10-09
    Available Online: 2023-05-31
    Abstract
  •   Objective  To evaluate the clinical effect of Xiaoxun Huazhuo Recipe on colorectal polyps with metabolic syndrome of spleen deficiency and phlegm dampness type, and to analyse the influence factors of colorectal polyps recurrence.  Methods  A total of 76 patients with intestinal polyps accompanied by metabolic syndrome were selected from Puxing Community Health Center from January 2020 to June 2021, the patients were randomly divided into treatment group and control group by random number method, with 38 cases in each group. The control group was given symptomatic treatment and health education, while the treatment group was given Xiaoxun Huazhuo Decoction. Both groups were treated continuously for 3 months. The recurrence rate of colorectal polyps and the changes of serum total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), fasting blood glucose (FPG), glycosylated haemoglobin (HbA1c), body weight, BMI, waist circumference (WC) and waist hip ratio (WHR) were compared between the two groups 12 months after the treatment. The influencing factors of recurrence were analysed by logistic regression model.  Results  The actual numbers of cases included were 37 in the treatment group and 38 in the control group. The recurrence rates of the two groups 12 months after the treatment were 10.8% (4/37) in the treatment group and 31.6% (12/38) in the control group, with a statistically significant difference (χ2=4.818, P=0.028). The differences in metabolic indices and body mass index (HbA1c, SBP, WHR, FPG, LDL-C) between the two groups before and after treatment were compared and found to be statistically significant (all P < 0.05). Multivariate analysis showed that treatment or not, red meat diet, family history, primary polyp size, BMI were related to recurrence.  Conclusion  Xiaoxun Huazhuo Recipe can reduce the recurrence rate of colorectal polyps 12 months after operation. Comprehensive diet control, exercise, regulation of metabolic abnormalities and active treatment of related diseases should be used as intervention strategies.

     

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