Volume 21 Issue 5
May  2023
Turn off MathJax
Article Contents
Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(5): 817-820
ZHANG Ji, ZHANG Chenli, CHEN Ming, REN Jiahui, YAO Bilian, WANG Zhenzhen, CHEN Ying, LU Wei. HP infection in community patients with hypertension treated with aspirin for ASCVD primary prevention[J]. Chinese Journal of General Practice, 2023, 21(5): 817-820. doi: 10.16766/j.cnki.issn.1674-4152.002991
Citation: ZHANG Ji, ZHANG Chenli, CHEN Ming, REN Jiahui, YAO Bilian, WANG Zhenzhen, CHEN Ying, LU Wei. HP infection in community patients with hypertension treated with aspirin for ASCVD primary prevention[J]. Chinese Journal of General Practice, 2023, 21(5): 817-820. doi: 10.16766/j.cnki.issn.1674-4152.002991
shu

HP infection in community patients with hypertension treated with aspirin for ASCVD primary prevention

doi: 10.16766/j.cnki.issn.1674-4152.002991
  • 1.

    Department of General Practice, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

Funds:

 200940005

  • Received Date: 2022-03-11
    Abstract
  •   Objective  This study aims to investigate and analyse the current situation of Helicobacter pylori (Hp) infection in community patients with hypertension treated with aspirin for ASCVD primary prevention.  Methods  A total of 100 hypertensive patients who were eligible for ASCVD primary prevention and had been taking low-dose aspirin for a long time in Dapuqiao Community from January 2020 to June 2021 were selected to investigate the previous histories of Helicobacter pylori infection and eradication before taking the medication. Helicobacter pylori testing was performed and grouped according to the results(Hp-positive and Hp-negative groups); atherosclerosis-related indexes were screened, and the test of the two groups were recorded and statistically analysed.  Results  Amongst the selected patients, 13 (13.00%) had been screened for Hp before taking aspirin; 7 cases were found to be infected with Hp through screening, and the Hp infection rate accounted for 53.85% of the screening population. All 7 cases with Hp infection had undergone eradication therapy, and 5 cases were successfully eradicated (the eradication success rate was 71.43%). In addition, 16 cases showed adverse reactions in the course of taking aspirin (the adverse reaction rate was 16.00%). All the selected cases underwent 13C-UBT breath test, and they were divided into the Hp-positive group (n=39) and Hp-negative group (n=61) based on the results. TC, TG and LDL-C in the Hp-positive group were significantly higher than those in the Hp-negative group (all P < 0.01). The comparison of the HOMA-IR index and BMI, which reflecting insulin resistance, between the two groups showed statistically significant differences (both P > 0.05). Carotid intima-media thickness (CIMT) in the Hp-positive group was significantly thicker than that in the Hp-negative group (P < 0.01).  Conclusion  The screening rate and eradication rate of Hp are low in community patients with hypertension treated with aspirin for ASCVD primary prevention. Hp infection may promote atherosclerosis by affecting glucose and lipid metabolism, increasing insulin resistance and increasing carotid intima-media thickness. Furthermore, Hp infection can aggravate the gastrointestinal damage from aspirin. Therefore, Hp should be screened and eradicated before taking medicine.

     

    • FullText(HTML)
  • loading
    • References(20)
  • [1]
    胡盛寿, 高润霖, 刘力生, 等. 《中国心血管病报告2018》概要[J]. 中国循环杂志, 2019, 34(3): 209-220. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGXH201903002.htm

    HU S S, GAO R L, LIU L S, et al. Summary of the 2018 Report on Cardiovascular Diseases in China[J]. Chinese Circulation Journal, 2019, 34(3): 209-220. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGXH201903002.htm
    [2]
    中华医学会老年医学分会, 《中华内科杂志》编辑委员会, 《中华老年医学杂志》编辑委员会. 阿司匹林在动脉粥样硬化性心血管疾病中的临床应用: 中国专家共识(2016)[J]. 中华内科杂志, 2017, 56(1): 68-80. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGXZ202003002.htm

    Chinese Geriatric Society, Editorial Board of Chinese Journal of Internal Medicine, editorial board of Chinese Journal of Geriatrics. Aspirin use in patients with atherosclerotic cardiovascular disease: the 2016 Chinese expert consensus statement[J]. Chinese Journal of Internal Medicine, 2017, 56(1): 68-80. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGXZ202003002.htm
    [3]
    CHOI J M, LIM S H, HAN Y M, et al. Association between helicobacter pylori infection and arterial stiffness: results from a large cross-sectional study[J]. PLoS One, 2019, 14(8): e0221643. DOI: 10.1371/journal.pone.0221643.
    [4]
    中国心血管病风险评估和管理指南编写联合委员会. 中国心血管病风险评估和管理指南[J]. 中华预防医学杂志, 2019, 53(1): 13-35. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGXH201901003.htm

    The Joint Task Force for Guideline on the Assessment and Management of Cardiovascular Risk in China. Guideline on the Assessment and Management of Cardiovascular Risk in China[J]. Chinese Circulation Journal, 2019, 53(1): 13-35. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGXH201901003.htm
    [5]
    2019阿司匹林在心血管疾病一级预防中的应用中国专家共识写作组. 2019阿司匹林在心血管疾病一级预防中的应用中国专家共识[J]. 中华心血管病杂志(网络版), 2019. DOI: 10.3760/cma.j.issn.2096-1588.2019.1000020.

    The application of aspirin in the primary prevention of cardiovascular diseases: Chinese Expert Consensus Writing Group. Chinese expert consensus on the application of aspirin in the primary prevention of cardiovascular diseases[J]. Chinese Journal of Cardiology (Online Edition), 2019. DOI: 10.3760/cma.j.issn.2096-1588.2019.1000020.
    [6]
    郭艺芳. 阿司匹林与高血压患者心血管疾病一级预防[J]. 中华内科杂志, 2019, 58(4): 249-251. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGGZ202007003.htm

    GUO Y F. 阿司匹林与高血压患者心血管疾病一级预防[J]. 中华内科杂志, 2019, 58(4): 249-251. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGGZ202007003.htm
    [7]
    MORA S, MANSON J E. Aspirin for primary prevention of atherosclerotic cardiovascular disease: advances in diagnosis and treatment[J]. JAMA Intern Med, 2016, 176(8): 1195-1204. doi: 10.1001/jamainternmed.2016.2648
    [8]
    李小鹰, 赵冬, 施仲伟. 再聚焦阿司匹林一级预防的临床证据[J]. 中华老年心脑血管病杂志, 2019, 21(4): 362-365. https://www.cnki.com.cn/Article/CJFDTOTAL-LNXG201904007.htm

    LI X Y, ZHAO D, SHI Z W. Refocus on clinical evidence of aspirin for the first degree prevention of cardiovascular diseases[J]. Chinese Journal of Geriatric Heart Brain and Vessel Diseases, 2019, 21(4): 362-365. https://www.cnki.com.cn/Article/CJFDTOTAL-LNXG201904007.htm
    [9]
    王晶璠, 盖亚男, 孙永华. 根除幽门螺杆菌预防长期服用小剂量阿司匹林患者上消化道黏膜损伤的临床研究[J]. 解放军医药杂志, 2017, 29(3): 69-72. https://www.cnki.com.cn/Article/CJFDTOTAL-HBGF201703019.htm

    WANG J P, GE Y N, SUN Y H. Clinical Study on Helicobacter Pylori Eradication Therapy in Prevention of Upper Digestive Tract Mucomembranous Injury in Patients Using Long-term Low Dose Aspirin[J]. Medical & Pharmaceutical Journal of Chinese People's Liberation Army, 2017, 29(3): 69-72. https://www.cnki.com.cn/Article/CJFDTOTAL-HBGF201703019.htm
    [10]
    中国医师协会心血管内科医师分会, 中国卒中学会, 国际血管联盟中国分部. 常用口服抗血小板药物不耐受及低反应性人群诊疗专家共识[J]. 中国介入心脏病学杂志, 2021, 29(5): 240-249. https://www.cnki.com.cn/Article/CJFDTOTAL-ZJXB202105001.htm

    Chinese Medical Doctor Association Cardiovascular Physicians Branch, Chinese Stroke Society, International Vascular Alliance China branch. Expert consensus on the diagnosis and treatment of patients with intolerance and low responsiveness to commonly used oral antiplatelet drugs[J]. Chinese Journal of Interventional Cardiology, 2021, 29(5): 240-249. https://www.cnki.com.cn/Article/CJFDTOTAL-ZJXB202105001.htm
    [11]
    NG J C, YEOMANS N D. Helicobacter pylori infection and the risk of upper gastrointestinal bleeding in low dose aspirin users: systematic review and meta-analysis[J]. Med J Aust, 2018, 209(7): 306-311.
    [12]
    祝喜萍, 任旭, 孙晓玲, 等. 阿司匹林对耐药幽门螺杆菌的体外影响[J]. 临床与病理杂志, 2019, 39(5): 928-932. https://www.cnki.com.cn/Article/CJFDTOTAL-WYSB201905003.htm

    ZHU X P, REN X, SUN X L, et al. Effect of aspirin on resistant helicobacter pylori in vitro[J]. Journal of Clinical and Pathological Research, 2019, 39(5): 928-932. https://www.cnki.com.cn/Article/CJFDTOTAL-WYSB201905003.htm
    [13]
    王运东, 罗和生. 根除幽门螺杆菌对长期联用阿司匹林和氯吡格雷者上消化道再出血发生率的影响[J]. 中华消化杂志, 2014, 34(2): 89-91. https://www.cnki.com.cn/Article/CJFDTOTAL-XDTZ201904141.htm

    WANG Y D, LUO H S. Effects of eradication of Helicobacter pylori on upper gastrointestinal rebleeding rate in patients with longterm aspirin and clopidogrel combination therapy[J]. Chinese Journal of Digestion, 2014, 34(2): 89-91. https://www.cnki.com.cn/Article/CJFDTOTAL-XDTZ201904141.htm
    [14]
    HOOI J, LAI W Y, NG W K, et al. Global Prevalence of Helicobacter pylori Infection: systematic review and meta-analysis[J]. Gastroenterology, 2017, 153(2): 420-429.
    [15]
    寿晓玲, 胡芬, 朱利月, 等. 幽门螺旋杆菌感染与原发性高血压患者靶器官功能损害相关性分析[J]. 中华医院感染学杂志, 2018, 28(12): 1819-1822. https://www.cnki.com.cn/Article/CJFDTOTAL-ZHYY201812014.htm

    SHOU X L, HU F, ZHU L Y, et al. Correlation between Helicobacter pylori infection and target organ dysfunction in patients with primary hypertension[J]. Chinese Journal of Nosocomiology, 2018, 28(12): 1819-1822. https://www.cnki.com.cn/Article/CJFDTOTAL-ZHYY201812014.htm
    [16]
    ADACHI K, MISHIRO T, TODA T, et al. Effects of Helicobacter pylori eradication on serum lipid levels[J]. J Clin Biochem Nutr, 2018, 62(3): 264-269.
    [17]
    WAN Z C, SONG L L, HU L, et al. Helicobacter pylori infection is associated with diabetes among Chinese adults[J]. J Diabetes Investig, 2020, 11(1): 199-205.
    [18]
    李静, 折剑青, 罗娟娟, 等. 老年高血压患者血压昼夜节律与颈动脉粥样硬化的相关性研究[J]. 中华全科医学, 2021, 19(4): 534-537. doi: 10.16766/j.cnki.issn.1674-4152.001854

    LI J, ZHE J Q, LUO J J, et al. Relationship between circadian rhythm of blood pressure and carotid atherosclerosis in the elderly with hypertension[J]. Chinese Journal of General Practice, 2021, 19(4): 534-537. doi: 10.16766/j.cnki.issn.1674-4152.001854
    [19]
    董雪珊, 陈子龙, 范文欣, 等. 幽门螺旋杆菌感染与颈动脉内膜中层厚度相关性的Meta分析[J]. 中国循环杂志, 2018, 33(4): 366-370. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGXH201804014.htm

    DONG X S, CHEN Z L, FAN W X, et al. Relationship Between Helicobacter Pylori Infection and Carotid Intima Thickness by Meta-analysis[J]. Chinese Circulation Journal, 2018, 33(4): 366-370. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGXH201804014.htm
    [20]
    YANG S, XIA Y P, LUO X Y, et al. Exosomal CagA derived from Helicobacter pylori-infected gastric epithelial cells induces macrophage foam cell formation and promotes atherosclerosis[J]. J Mol Cell Cardiol, 2019, 135: 40-51.
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Tables(3)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (248) PDF downloads(6) Cited by()
    Proportional views
    Related

    Address：No. 287, Changhuai Road, Bengbu, Anhui Province, 233004, P.R.ChinaphoneNo：0552-3066635； 0552-3051890Email：zhqkyx@163.com

    Copyright © Chinese Journal of General Practice皖ICP备2020018345号-2

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return