Volume 21 Issue 6
Jun.  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(6): 945-949
MA Yong, CHEN Shanqin, FU Jun, HANG Qun. Relationship between serum fibrinogen and albumin/globulin ratio levels and survival prognosis of patients with gastric cancer[J]. Chinese Journal of General Practice, 2023, 21(6): 945-949. doi: 10.16766/j.cnki.issn.1674-4152.003021
Citation: MA Yong, CHEN Shanqin, FU Jun, HANG Qun. Relationship between serum fibrinogen and albumin/globulin ratio levels and survival prognosis of patients with gastric cancer[J]. Chinese Journal of General Practice, 2023, 21(6): 945-949. doi: 10.16766/j.cnki.issn.1674-4152.003021
shu

Relationship between serum fibrinogen and albumin/globulin ratio levels and survival prognosis of patients with gastric cancer

doi: 10.16766/j.cnki.issn.1674-4152.003021

  • Department of Gastrointestinal Surgery, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China

Funds:

 KJ2021A0765

  • Received Date: 2022-09-20
    Available Online: 2023-08-26
    Abstract
  •   Objective  Studies have found that preoperative serum fibrinogen (FIB) and albumin/globulin ratio (AGR) are correlated with the prognosis of malignant tumors. Currently, there are few studies on the relationship between serum FIB and AGR and the survival prognosis of patients with gastric cancer. This study explores the relationship between preoperative serum FIB and AGR and the survival prognosis of patients with gastric cancer.  Methods  A total of 222 patients who underwent radical gastritis in the First Affiliated Hospital of Bengbu Medical College from January 2013 to December 2016 were included. The preoperative serum FIB and AGR levels and clinic pathological characteristics of patients with gastric cancer were analyzed retrospectively. The optimal truncation values of FIB and AGR were obtained by drawing ROC curves. According to the truncation values, patients were divided into high FIB group and low FIB group, high AGR group and low AGR group. The relationship between serum FIB, AGR grouping and clinicopathological features of patients with gastric cancer was analyzed successively. Kaplan-Meier survival curve was used for survival analysis, and Cox proportional risk model was used to study independent risk factors affecting prognosis of patients with gastric cancer.  Results  The optimal truncation values of FIB and AGR were 3.33 g/L and 1.46, respectively. Preoperative serum FIB was correlated with body mass index, differentiation degree, tumor size, T stage, N stage, TNM stage, CEA and CA19-9. Preoperative serum AGR was correlated with age, body mass index, degree of differentiation, tumor size, T stage, N stage, TNM stage, CEA and CA19-9. Survival analysis suggested that the OS rate and mean OS time in the low FIB group were significantly higher than those in the high FIB group (57.6% vs. 14.4%, 74.8 months vs. 32.9 months, P < 0.001). The OS rate and mean OS time in the high AGR group were also significantly higher than those in the low AGR group (56.8% vs.18.6%, 73.7 months vs.38.5 months, P < 0.001). Multivariate analysis showed that low differentiation degree, tumor size (≥5 cm), N stage, high FIB and low AGR were independent risk factors affecting the prognosis of patients with gastric cancer.  Conclusion  Preoperative serum FIB and AGR can be used as important blood indexes to predict the survival and prognosis of patients with gastric cancer.

     

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  • [1]
    WANG F H, ZHANG X T, LI Y F, et al. The Chinese Society of Clinical Oncology (CSCO): clinical guidelines for the diagnosis and treatment of gastric cancer, 2021[J]. Cancer Commun (Lond), 2021, 41(8): 747-795. doi: 10.1002/cac2.12193
    [2]
    张竞尧, 田艳涛, 王成锋, 等. 早期胃癌内镜黏膜下剥离术后腹腔镜补救手术的临床分析[J]. 北京医学, 2020, 42(4): 279-282. doi: 10.15932/j.0253-9713.2020.04.003

    ZHANG J Y, TIAN Y T, WANG C F, et al. Clinical analysis of laparoscopic rescue gastrectomy after endoscopic submucosal dissection in early gastric cancer[J]. Beijing Medical Journal, 2020, 42(4): 279-282. doi: 10.15932/j.0253-9713.2020.04.003
    [3]
    WU M, PAN Y, JIA Z, et al. Preoperative plasma fibrinogen and serum albumin score is an independent prognostic factor for resectable stage Ⅱ-Ⅲ Gastric Cancer[J]. Dis Markers, 2019, 2019(6): 9060845. DOI: 10.1155/2019/9060845.
    [4]
    LIANG Y, WANG W, QUE Y, et al. Prognostic value of the fibrinogen/albumin ratio (FAR) in patients with operable soft tissue sarcoma[J]. BMC Cancer, 2018, 18(1): 942-952. doi: 10.1186/s12885-018-4856-x
    [5]
    WEN L, GUO L, ZHANG W, et al. Cooperation between the inflammation and coagulation Systems promotes the survival of circulating tumor cells in renal cell carcinoma patients[J]. Front Oncol, 2019, 9(5): 504.
    [6]
    PAPILA KUNDAKTEPE B, PAPILA C. The clinical significance of preoperative plasma fibrinogen levels and platelet counts in resectable colon cancer[J]. World J Surg Oncol, 2021, 19(1): 69. doi: 10.1186/s12957-021-02180-y
    [7]
    YE X W, HU H J, XIONG X Z, et al. The preoperative elevated plasma fibrinogen level is associated with the prognosis of hilar cholangiocarcinoma[J]. Surg Today, 2021, 51(8): 1352-1360. doi: 10.1007/s00595-021-02249-x
    [8]
    MA J Y, LIU G, PAN L Z, et al. Clinical impact of pretreatment albumin-globulin ratio in patients with colorectal cancer: a meta-analysis[J]. Medicine (Baltimore), 2022, 101(20): e29190. DOI: 10.1097/MD.0000000000029190.
    [9]
    ZHANG H, ZHANG B, ZHU K, et al. Preoperative albumin-to-globulin ratio predicts survival in patients with non-small-cell lung cancer after surgery[J]. J Cell Physiol, 2019, 234(3): 2471-2479. doi: 10.1002/jcp.26766
    [10]
    ATSUMI Y, KAWAHARA S, KAKUTA S, et al. Low preoperative albumin-to-globulin ratio is a marker of poor prognosis in patients with esophageal cancer[J]. In Vivo, 2021, 35(6): 3555-3561. doi: 10.21873/invivo.12658
    [11]
    OHARA S, SUDA K, TOMIZAWA K, et al. Prognostic value of plasma fibrinogen and D-dimer levels in patients with surgically resected non-small cell lung cancer[J]. Surg Today, 2020, 50(11): 1427-1433. doi: 10.1007/s00595-020-02019-1
    [12]
    LIU C, NING Y, CHEN X, et al. D-Dimer level was associated with prognosis in metastatic colorectal cancer: a chinese patients based cohort study[J]. Medicine (Baltimore), 2020, 99(7): e19243. DOI: 10.1097/MD.0000000000019243.
    [13]
    WANG M, ZHANG G, ZHANG Y, et al. Fibrinogen alpha chain knockout promotes tumor growth and metastasis through Integrin-AKT signaling pathway in lung cancer[J]. Mol Cancer Res, 2020, 18(7): 943-954. doi: 10.1158/1541-7786.MCR-19-1033
    [14]
    KWAAN H C, LINDHOLM P F. Fibrin and fibrinolysis in cancer[J]. Semin Thromb Hemost, 2019, 45(4): 413-422. doi: 10.1055/s-0039-1688495
    [15]
    LI X, SHU K, ZHOU J, et al. Preoperative plasma fibrinogen and D-dimer as prognostic biomarkers for non-muscle-invasive bladder cancer[J]. Clin Genitourin Cancer, 2020, 18(1): 11-19. doi: 10.1016/j.clgc.2019.10.025
    [16]
    CHUNG K H, LEE J C, LEE J, et al. Serum fibrinogen as a diagnostic and prognostic biomarker for pancreatic ductal adenocarcinoma[J]. Pancreatology, 2020, 20(7): 1465-1471. doi: 10.1016/j.pan.2020.06.010
    [17]
    潘婉婉, 董孟浩, 余发智, 等. 外周血炎症指标NLR、PLR、LMR预测乳腺癌新辅助化疗疗效的价值[J]. 中华全科医学, 2021, 19(9): 1442-1446. doi: 10.16766/j.cnki.issn.1674-4152.002081

    PAN W W, DONG M H, YU F Z, et al. Value of peripheral inflammatory markers NLR, PLR and LMR in predicting the efficacy of neoadjuvant chemotherapy for breast cancer[J]. Chinese Journal of General Practice, 2021, 19(9): 1442-1446. doi: 10.16766/j.cnki.issn.1674-4152.002081
    [18]
    ECKART A, STRUJA T, KUTZ A, et al. Relationship of nutritional status, inflammation, and serum albumin levels during acute illness: a prospective study[J]. Am J Med, 2020, 133(6): 713-722. doi: 10.1016/j.amjmed.2019.10.031
    [19]
    YANG H, WEI B, HU B. Chronic inflammation and long-lasting changes in the gastric mucosa after helicobacter pylori infection involved in gastric cancer[J]. Inflamm Res, 2021, 70(10-12): 1015-1026. doi: 10.1007/s00011-021-01501-x
    [20]
    QEADAN F, BANSAL P, HANSON J A, et al. The MK2 pathway is linked to G-CSF, cytokine production and metastasis in gastric cancer: a novel intercorrelation analysis approach[J]. J Transl Med, 2020, 18(1): 137. doi: 10.1186/s12967-020-02294-z
    [21]
    SOETERS P B, WOLFE R R, SHENKIN A. Hypoalbuminemia: pathogenesis and clinical significance[J]. JPEN J Parenter Enteral Nutr, 2019, 43(2): 181-193. doi: 10.1002/jpen.1451
    [22]
    SU H, YANG F, SUN B, et al. Macropinocytosis: the big drinker behind cancer cell self-consumption[J]. Autophagy, 2021, 17(5): 1290-1291. doi: 10.1080/15548627.2021.1919969
    [23]
    BELINSKAIA D A, VORONINA P A, SHMURAK V I, et al. Serum albumin in health and disease: esterase, antioxidant, transporting and signaling properties[J]. Int J Mol Sci, 2021, 22(19): 10318. DOI: 10.3390/ijms221910318.
    [24]
    HART P C, RAJAB I M, ALEBRAHEEM M, et al. C-reactive protein and cancer-diagnostic and therapeutic insights[J]. Front Immunol, 2020, 11: 595835. DOI: 10.3389/fimmu.2020.595835.
    [25]
    BOCKERSTETT K A, DIPAOLO R J. Regulation of gastric carcinogenesis by inflammatory cytokines[J]. Cell Mol Gastroenterol Hepatol, 2017, 4(1): 47-53. doi: 10.1016/j.jcmgh.2017.03.005
    [26]
    YANG E, CHUA W, NG W, et al. Peripheral cytokine levels as a prognostic indicator in gastric cancer: a review of existing literature[J]. Biomedicines, 2021, 9(12): 1916. doi: 10.3390/biomedicines9121916
    [27]
    PFENSIG C, DOMINIK A, BORUFKA L, et al. A new application for albumin dialysis in extracorporeal organ support: characterization of a putative interaction between human albumin and proinflammatory cytokines IL-6 and TNF-α[J]. Artif Organs, 2016, 40(4): 397-402. doi: 10.1111/aor.12557
    [28]
    GOUNDEN V, VASHISHT R, JIALAL I. Hypoalbuminemia[M]. (2022-08-29)[2022-12-15]. https://www.ncbi.nlm.nih.gov/books/NBK526080/#_NBK526080_pubdet_.
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