Volume 21 Issue 9
Sep.  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(9): 1495-1497
WANG Li, CUI Zhuo, GUO Pu, ZHANG Xiangjun, ZHU Jingrui. Characteristics and drug resistance of Pseudomonas aeruginosa infection in a general hospital[J]. Chinese Journal of General Practice, 2023, 21(9): 1495-1497. doi: 10.16766/j.cnki.issn.1674-4152.003154
Citation: WANG Li, CUI Zhuo, GUO Pu, ZHANG Xiangjun, ZHU Jingrui. Characteristics and drug resistance of Pseudomonas aeruginosa infection in a general hospital[J]. Chinese Journal of General Practice, 2023, 21(9): 1495-1497. doi: 10.16766/j.cnki.issn.1674-4152.003154
shu

Characteristics and drug resistance of Pseudomonas aeruginosa infection in a general hospital

doi: 10.16766/j.cnki.issn.1674-4152.003154
  • 1.

    Department of Hospital Infection Management, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China

Funds:

 KJ2021A0761

 人文社会科学重点项目，2021byzd278sk

  • Received Date: 2022-10-09
    Available Online: 2023-10-19
    Abstract
  •   Objective  To study the clinical distribution characteristics and drug resistance changes of Pseudomonas aeruginosa infection in hospital, so as to provide basis for prevention and control of hospital infection and rational use of antibacterial drugs.  Methods  The distribution and drug resistance of Pseudomonas aeruginosa in hospitalized patients from January 2019 to December 2021 were searched by electronic medical record system and hospital infection real-time monitoring system. The relevant data were statistically analyzed by Whonet 5.6 software and SPSS 25.0.  Results  A total of 1 106 strains of non-duplicated Pseudomonas aeruginosa were detected in hospitalized patients from 2019 to 2021, with the highest detection rate in intensive care units (25.68%), followed by emergency departments (9.22%) and respiratory departments (8.23%). Among all kinds of samples submitted for examination, respiratory tract samples accounted for 63.02%, followed by pus (9.40%) and urine samples (3.44%). The detected Pseudomonas aeruginosa showed different degrees of resistance to commonly used clinical antimicrobials, with the highest resistance rate being ciprofloxacin (37.79%) and the lowest resistance rate being amikacin (18.90%). The resistance rate to imipenem and ciprofloxacin exceeded 30% for 3 consecutive years. The resistance rates to cefepime, aztreonam, tobramycin, gentamicin and amikacin showed a downward trend, and the differences in resistance rates during the three years were statistically significant (all P < 0.05). The fluctuation of levofloxacin and ciprofloxacin resistance rate during three years was statistically different (P < 0.05).  Conclusion  The infection of Pseudomonas aeruginosa is mainly distributed in the intensive care unit, mainly respiratory tract infection, and the resistance rate to common clinical antibiotics shows different trends in the past 3 years. Carbapenem-resistant Pseudomonas aeruginosa strains are still one of the focuses of clinical attention. In the future clinical work, it is necessary to continuously monitor the prevalence and drug resistance of Pseudomonas aeruginosa in order to provide effective basis for infection prevention and control.

     

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    • References(18)
  • [1]
    ZHANG Y, LI Y, ZENG J, et al. Risk Factors for mortality of inpatients with Pseudomonas aeruginosa bacteremia in China: impact of resistance profile in the mortality[J]. Infect Drug Resist, 2020, 13: 4115-4123. doi: 10.2147/IDR.S268744
    [2]
    BHARDWAJ S, BHATIA S, SINGH S, et al. Growing emergence of drugresistant Pseudomonas aeruginosa and attenuation of its virulence using quorum sensing inhibitors: a critical review[J]. Iran J Basic Med Sci, 2021, 24(6): 699-719.
    [3]
    聂亚红, 田可港, 孙玉娟, 等. 医院铜绿假单胞菌的临床特征及危险因素分析[J]. 中国抗生素杂志, 2021, 46(6): 611-615. https://www.cnki.com.cn/Article/CJFDTOTAL-ZKSS202106017.htm

    NIE Y H, TIAN K G, SUN Y G, et al. Clinical characteristics and risk factors analysis of Pseudomonas aeruginosa in hospitals[J]. Chinese Journal of Antibiotics, 2021, 46(6): 611-615. https://www.cnki.com.cn/Article/CJFDTOTAL-ZKSS202106017.htm
    [4]
    CHINET中国细菌耐药监测网. 2020年CHINET中国细菌耐药监测结果[R/OL]. (2021-02-22)[2021-03-05]. http://www.chinets.com/Chinet.

    CHINET China Bacterial Drug Resistance Monitoring network. Results of bacterial drug resistance monitoring in China in 2020[R/OL]. (2021-02-22)[2021-03-05]. http://www.chinets.com/Chinet.
    [5]
    ASLAM B, WANG W, ARSHAD M I, et al. Antibiotic resistance: a rundown of a global crisis[J]. Infect Drug Resist, 2018, 11: 1645-1658. doi: 10.2147/IDR.S173867
    [6]
    洪燕, 郭海萍, 陈金连, 等. 某院恶性肿瘤患者多重耐药菌感染监测及危险因素分析[J]. 中华全科医学, 2020, 18(2): 314-317. doi: 10.16766/j.cnki.issn.1674-4152.001234

    HONG Y, GUO H P, CHEN J L, et al. Surveillance and risk factors analysis of multi-drug resistant bacteria infection in patients with malignant tumors in a hospital[J]. Chinese Journal of General Practice, 2020, 18(2): 314-317. doi: 10.16766/j.cnki.issn.1674-4152.001234
    [7]
    曾婷, 曾凌, 曹先伟, 等. 耐碳青霉烯类铜绿假单胞菌耐药基因与药敏分析[J]. 中华医院感染学杂志, 2019, 29(20): 3063-3067. https://www.cnki.com.cn/Article/CJFDTOTAL-ZHYY201920006.htm

    ZENG T, ZENG L, CAO X W, et al. Analysis of drug resistance genes and drug susceptibility of carbapenem resistant Pseudomonas aeruginosa[J]. Chinese Journal of Nosocomiology, 2019, 29(20): 3063-3067. https://www.cnki.com.cn/Article/CJFDTOTAL-ZHYY201920006.htm
    [8]
    ASEMPA T E, NICOLAU D P, KUTI J L. Carbapenem nonsusceptible Pseudomonas aeruginosa isolates from intensive care units in the United States: a potential role for new β-Lactam combination agents[J]. J Clin Microbiol, 2019, 57(8): e00535-19. DOI: 10.1128/JCM.00535-19.
    [9]
    吴振安, 张亮. 铜绿假单胞菌的临床分布及耐药性分析[J]. 中国临床医生杂志, 2021, 49(1): 55-57.

    WU Z A, ZHANG L. Analysis of clinical distribution and drug resistance of Pseudomonas aeruginosa[J]. Chinese Journal of Clinical Doctors, 2021, 49(1): 55-57.
    [10]
    PANG Z, RAUDONIS R, GLICK B R, et al. Antibiotic resistance in Pseudomonas aeruginosa: mechanisms and alternative therapeutic strategies[J]. Biotechnol Adv, 2019, 37(1): 177-192. doi: 10.1016/j.biotechadv.2018.11.013
    [11]
    程鹏, 冯文聪, 欧阳豪, 等. 铜绿假单胞菌医院感染的临床分布及耐药性分析[J]. 深圳中西医结合杂志, 2021, 31(20): 110-112.

    CHENG P, FENG W C, OUYANG H, et al. Analysis of clinical distribution and drug resistance of Pseudomonas aeruginosa nosocomial infection[J]. Shenzhen Journal of Integrated Traditional Chinese and Western Medicine, 2021, 31(20): 110-112.
    [12]
    张玉琳, 艾志琼, 卢昂, 等. 2015—2019年某医院铜绿假单胞菌感染的临床分布及耐药性动态分析研究[J]. 大理大学学报, 2021, 6(2): 86-89.

    ZHANG Y L, AI Z Q, LU A. Clinical distribution and drug resistance dynamic analysis of Pseudomonas aeruginosa infection in a hospital from 2015 to 2019[J]. Journal of Dali University, 2021, 6(2): 86-89.
    [13]
    LI W, LUO Y, SHEN Z, et al. A novel inactivated whole-cell Pseudomonas aeruginosa vaccine that acts through the cGAS-STING pathway[J]. Signal Transduct Target Ther, 2021, 6(1): 353.
    [14]
    AMINNEZHAD S, ABDI-ALI A, GHAZANFARI T, et al. Immunoinformatics design of multivalent chimeric vaccine for modulation of the immune system in Pseudomonas aeruginosa infection[J]. Infect Genet Evol, 2020, 85: 104462. DOI: 10.1016/j.meegid.2020.104462.
    [15]
    MCCANN E, SRINIVASAN A, DERYKE C A, et al. Carbapenem-nonsusceptible gram-negative pathogens in ICU and non-ICU settings in US hospitals in 2017: a multicenter study[J]. Open Forum Infect Dis, 2018, 5(10): ofy241. DOI: 10.1093/ofid/ofy241.
    [16]
    王嵩宇, 张雪云. 2016至2019年某三甲医院常见病原菌分布及细菌耐药性变迁[J]. 沈阳医学院学报, 2022, 24(1): 40-45. https://www.cnki.com.cn/Article/CJFDTOTAL-SYYX202201011.htm

    WANG S Y, ZHANG X Y. Distribution of common pathogens and changes of bacterial drug resistance in a tertiary hospital from 2016 to 2019[J]. Journal of Shenyang Medical College, 2022, 24(1): 40-45. https://www.cnki.com.cn/Article/CJFDTOTAL-SYYX202201011.htm
    [17]
    吴志农, 熊敏, 谢丹, 等. 耐碳青霉烯铜绿假单胞菌医院感染的临床特征及危险因素分析[J]. 现代检验医学杂志, 2020, 35(5): 137-141.

    WU Z N, XIONG M, XIE D. Clinical characteristics and risk factors analysis of aeruginosa infection of carbapenem resistant Pseudomonas aeruginosa[J]. Journal of Modern Laboratory Medicine, 2020, 35(5): 137-141.
    [18]
    FOLIC M M, DJORDJEVIC Z, FOLIC N, et al. Epidemiology and risk factors for healthcare-associated infections caused by Pseudomonas aeruginosa[J]. J Chemother, 2021, 33(5): 294-301.
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