Volume 21 Issue 9
Sep.  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(9): 1544-1546
SONG Jian, CUI Beiyong, ZHU Hongwei. Therapeutic effect of triptorelin combined with recombinant human growth hormone on central precocious puberty in girls[J]. Chinese Journal of General Practice, 2023, 21(9): 1544-1546. doi: 10.16766/j.cnki.issn.1674-4152.003166
Citation: SONG Jian, CUI Beiyong, ZHU Hongwei. Therapeutic effect of triptorelin combined with recombinant human growth hormone on central precocious puberty in girls[J]. Chinese Journal of General Practice, 2023, 21(9): 1544-1546. doi: 10.16766/j.cnki.issn.1674-4152.003166
shu

Therapeutic effect of triptorelin combined with recombinant human growth hormone on central precocious puberty in girls

doi: 10.16766/j.cnki.issn.1674-4152.003166
  • 1.

    Department of Pediatrics, Bengbu First People' s Hospital, Bengbu, Anhui 233000, China

Funds:

 KJ2021A0797

  • Received Date: 2022-06-06
    Available Online: 2023-10-19
    Abstract
  •   Objective  To study the clinical effect of triptorelin combined with recombinant human growth hormone in the treatment of girls with central precocious puberty (CPP).  Methods  Sixty girls with CPP admitted to Department of Pediatrics of Bengbu First People's Hospital from August 2018 to August 2020 were divided into control group (n=30) and study group (n=30).The control group was given triptorelin therapy, and the study group was given triptorelin combined with recombinant human growth hormone therapy.The changes of sex hormone level, insulin-like growth factor-1(IGF-1), insulin-like growth factor binding protein-3(IGFBP-3), clinical efficacy and incidence of adverse reactions were observed.  Results  There were no significant differences in the levels of FSH[(2.52±0.63) U/L vs.(2.42±0.56) U/L], LH[(1.56±0.52) U/L vs.(1.62±0.60) U/L]and E2[(10.84±2.50) ng/L vs.(12.10±3.20) ng/L]between the control group and the study group after treatment (P>0.05).IGF-1[(345.62±39.65)μg/L vs.(282.02±25.40)μg/L]and IGFBP-3[(5.54±2.64) mg/L vs.(4.22±1.46) mg/L]levels in the study group were significantly higher than those in the control group after treatment, and the differences were statistically significant (all P < 0.05).The levels of predicted adult height[(161.4±5.2) cm vs.(154.2±3.8) cm]and growth velocity[(9.8±2.8) cm per year vs.(6.2±2.0) cm per year]in the study group were significantly higher than those in the control group, and the differences were statistically significant (all P < 0.05).But there was no significant difference in bone age[(10.3±0.5) year of age vs.(10.1±0.7) year of age]between the two groups after treatment (P>0.05).The adverse reactions of the two groups of children were mild, the incidence was not high and could be controlled by treatment.  Conclusion  Triptorelin combined with recombinant human growth hormone has a significant effect in the treatment of girls with CPP.It has positive significance for growth and development indicators, and is worthy of clinical promotion and application.

     

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