Volume 21 Issue 11
Nov.  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(11): 1865-1867
GAO Zongbin, YANG Guang, SHI Zhou, HU Jun, WANG Ping. Effects of alfentanil on traction pain and shivering during combined spina-epidural anesthesial for cesarean section[J]. Chinese Journal of General Practice, 2023, 21(11): 1865-1867. doi: 10.16766/j.cnki.issn.1674-4152.003244
Citation: GAO Zongbin, YANG Guang, SHI Zhou, HU Jun, WANG Ping. Effects of alfentanil on traction pain and shivering during combined spina-epidural anesthesial for cesarean section[J]. Chinese Journal of General Practice, 2023, 21(11): 1865-1867. doi: 10.16766/j.cnki.issn.1674-4152.003244
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Effects of alfentanil on traction pain and shivering during combined spina-epidural anesthesial for cesarean section

doi: 10.16766/j.cnki.issn.1674-4152.003244
  • 1.

    Department of Anesthesiology, Tongling People's Hospital, Tongling, Anhui 244000, China

Funds:

 81901086

  • Received Date: 2023-04-23
    Available Online: 2024-01-13
    Abstract
  •   Objective  To investigate the effect of alfentanil on the prevention of traction pain and shivering in puerperae during combined spina/epidural anesthesia (CSEA) cesarean section, to provide a reference for clinical work.  Methods  A total of 62 parturients who underwent cesarean section under combined spinal-epidural anesthesia at Tongling People's Hospital from January to December 2022 were selected and randomly divided into two groups using a random number table: alfentanil group (group A) and control group (group C), 31 cases per group. After anesthesia, the level of anesthesia sensation was adjusted to T6-8.After delivery of the umbilical cord, alfentanil 3 μg/kg was injected intravenously, then continuous intravenous infusion alfentanil at 0.125 μg/(kg·min); Group C puerperae were given the same dose of normal saline after delivery of the umbilical cord clamping until the end of the operation. We recorded the general situation, intraoperative traction pain, shivering, skin itching, nausea, vomiting and meionectic blood rates in the groups, mean arterial pressure (MAP) and heart rate (HR) of puerperaeat at each time point.  Results  There was no significant difference in general condition between the two groups of parturients (P > 0.05), There was a significant difference in the incidence of traction pain between the two groups [22.58%(7/31) vs. 56.67%(17/30), P < 0.05]. Group A had no moderate to severe traction pain, and the incidence of tremor in Group A (6.5%, 2/31) was significantly lower than that in Group C (33.3%, 10/30, χ2=6.972, P < 0.05). There was no significant difference in the incidence of pruritus, nausea, and vomiting between the two groups of parturients (P > 0.05). There was no significant difference in MAP and HR at different time points between the two groups of parturients (MAP: Finterblock=0.142, P=0.708; HR: Finterblock=0.006, P=0.937), there was a statistically significant difference at different time points within the group (MAP: Ftime=24.434, P < 0.001;HR: Ftime=11.045, P < 0.001), and there was no interaction between the group and time (MAP: Finteraction=1.107, P=0.355; HR: Finteraction=0.616, P=0.659).  Conclusion  Alfentanil can effectively prevent traction reaction and shivering in cesarean section under CSEA.

     

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    • References(20)
  • [1]
    CHEN X R, GAO T, ZHANG Y, et al. Addition of low-dose sufentanil to ropivacaine for reducing shivering and visceral traction pain during cesarean section[J]. J Int Med Res, 2021, 49(5): 2962-2965.
    [2]
    YAN W, XIONG Y, YAO Y, et al. Continuous intravenous infusion of remifentanil improves the experience of parturient undergoing repeated cesarean section under epidural anesthesia, a prospective, randomized study[J]. BMC Anesthesiol, 2019, 19(1): 243-249. doi: 10.1186/s12871-019-0900-x
    [3]
    郑丽花, 杨淑芬, 兰允平, 等. 艾司氯胺酮复合顺阿曲库铵麻醉诱导在急诊剖宫产中的效果观察[J]. 中华全科医学, 2022, 20(4): 602-605. doi: 10.16766/j.cnki.issn.1674-4152.002410

    ZHENG L H, YANG S F, LAN Y P, et al. Effect of anesthesia induction with esmketamine combined with cisatracurium in emergency cesarean section[J]. Chinese Journal of General Practice, 2022, 20(4): 602-605. doi: 10.16766/j.cnki.issn.1674-4152.002410
    [4]
    王金伙, 郭建荣. 阿芬太尼的临床药理特性及其麻醉应用进展[J]. 中国临床药理学与治疗学, 2021, 26(7): 824-829.

    WANG J H, GUO J R. Clinical pharmacological properties of alfentanil and its progress in anes-thetic application[J]. Chinese Journal Clinical Pharmacology and Therapeutics, 2021, 26(7): 824-829.
    [5]
    MILDH L H, SCHEININ H, KIRVELA O A. The concentration-effect relationship of the respiratory depressant effects of alfentanil and fentany[J]. Anesth Analg, 2021, 93(4): 939-946.
    [6]
    SEKI H, SHIGA T, MIHARA T, et al. Effects of intrathecal opioids on cesarean section: a systematic review and Bayesian network meta-analysis of randomized controlled trials[J]. J Anesth, 2021, 35(6): 911-927. doi: 10.1007/s00540-021-02980-2
    [7]
    WHITE L, HODSDON A, AN G H, et al. Induction opioids for caesarean section under general anaesthesia: a systematic review and meta-analysis of randomised controlled trials[J]. Int J Obstet Anesth, 2019, 40: 4-13. doi: 10.1016/j.ijoa.2019.04.007
    [8]
    FANG Z, ZOU D, XIONG W, et al. Dynamic prediction of hypoxemia risk at different time points based on preoperative and intraoperative features: machine learning applications in outpatients undergoing esophagogastroduodenoscopy[J]. Ann Med, 2023, 55(1): 1156-1167.
    [9]
    杜静, 孙传良. 布托啡诺滴鼻用于首次剖宫产产妇镇痛的效果[J]. 临床麻醉学杂志, 2021, 37(9): 977-978.

    DU J, SUN C L. The analgesic effect of intranasal butorphanol in parturients undergoing primary cesarean section[J]. Journal of Clinical Anesthesiology, 2021, 37(9): 977-978.
    [10]
    刘占立, 朱丽洁, 刘颖程, 等. 不同剂量右美托咪定在剖宫产产妇术后多模式镇痛效果的比较[J]. 临床麻醉学杂志, 2022, 38(8): 810-814.

    LIU Z L, ZHU L J, LIU Y C, et al. Comparison of different doses of dexmedetomidine in postoperative multimodal analgesia for puer-pera after cesarean section[J]. Journal of Clinical Anesthesiology, 2022, 38(8): 810-814.
    [11]
    岳晓敏, 贺建东, 王晓鹏, 等. 不同剂量纳布啡对腰-硬联合麻醉剖宫产产妇寒战的影响[J]. 临床麻醉学杂志, 2021, 37(1): 46-49.

    YUE X M, HE J D, WANG X P, et al. Efficacy of different doses of nalbuphine for prevention of shivering after combined spinal-epidural anesthesia in patients undergoing caesarean section[J]. Journal of Clinical Anesthesiology, 2021, 37(1): 46-49.
    [12]
    叶君, 周结贤, 梁俏丽. 丙泊酚抑制剖宫产术中内脏牵拉反射及对妊娠终局的影响[J]. 海南医学, 2021, 32(3): 323-326.

    YE J, ZHOU J X, LIANG Q L, et al. Effect of propofol on the inhibition of visceral traction reflex and the end of pregnancy in cesarean section[J]. Hainan Medical Journal, 2021, 32(3): 323-326.
    [13]
    唐华东, 王晋, 孙浩然. 超声引导下经阴道穿刺取卵术麻醉中阿芬太尼剂量选择和效果分析[J]. 中国计划生育学杂志, 2023, 31(4): 799-803.

    TANG H D, WANG J, SUN H R, et al. Dosage selection and effect analysis of alfentanil for anesthesia during the operation of transvaginal puncture and ova col-lection under ultrasound guidance[J]. Chinese Journal of Family Planning, 2023, 31(4): 799-803.
    [14]
    陈洁娟, 邹小华, 陈佳, 等. 不同剂量阿芬太尼复合丙泊酚用于无痛胃镜检查的效果[J]. 临床麻醉学杂志, 2022, 38(1): 46-51.

    CHEN J J, ZHOU X H, CHEN J, et al. Effects of different doses of alfentanil combined with propofol on painless gastroscopy[J]. Journal of Clinical Anesthesiology, 2022, 38(1): 46-51.
    [15]
    白云波, 徐铭军, 李晓光. 右美托咪定在剖宫产术麻醉与分娩镇痛中的研究进展[J]. 中华妇幼临床医学杂志(电子版), 2019, 15(5): 601-604.

    BAI Y B, XU M J, LI X G, et al. Research progress of dexmedetomidine in anesthesia and labor analgesia of cesarean section[J]. Chinese Journal of Obstetrics & Gynecplogy and Pediatrics, 2019, 15(5): 601-604.
    [16]
    张荦, 马蓓, 张建友, 等. 剖宫产产妇术中寒战的危险因素[J]. 临床麻醉学杂志, 2022, 38(8): 837-840.

    ZHANG L, MA B, ZHANG J Y, et al. Risk factors of intraoperative shivering in puerpera undergoing cesarean section[J]. Journal of Clinical Anesthesiology, 2022, 38(8): 837-840.
    [17]
    李娅男, 宋春燕, 易丽萍. 剖宫产产妇术中发生寒战的风险模型构建[J]. 浙江临床医学, 2023, 25(3): 374-376.

    LI Y N, SONG C Y, YI L P. The establishment of a risk prediction model for shivering during cesarean section[J]. Zhejiang Clinical Medical Journal, 2023, 25(3): 374-376.
    [18]
    SEKI H, SHIGA T, MIHARA T, et al. Effects of intrathecal opioids on cesarean section: a systematic review and Bayesian network meta-analysis of randomized controlled trials[J]. J Anesth, 2021, 35(6): 911-927.
    [19]
    李子超, 肖洪一, 朱腾, 等. 阿芬太尼复合丙泊酚在日间宫腔镜手术麻醉中的应用效果观察[J]. 山东医药, 2022, 62(6): 72-75.

    LI Z C, XIAO H Y, ZHU T, et al. The application of alfentanil combined with propofol anesthesia in ambulatory hysteroscopy surgery[J]. Shandong Medical Journal, 2022, 62(6): 72-75.
    [20]
    陈明华, 薛富善, 冯艺, 等. 盐酸阿芬太尼注射液在全身麻醉中有效性和安全性研究: 一项多中心、双盲、对照研究[J]. 中国药理学通报, 2022, 38(10): 1504-1510.

    CHEN M H, XUE F S, FENG Y, et al. Efficacy and safety of alfentanil hydrochloride injection in general anesthesia: a multicenter, double-blind, controlled study[J]. Chinese Pharmacology Bulletin, 2022, 38(10): 1504-1510.
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