Volume 22 Issue 2
Feb.  2024
Turn off MathJax
Article Contents
Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(2): 212-216
WANG Kaiyang, LIU Fengshuang, LIU Yongguo, LI Guoqing, YANG Yining, YU Xiaolin. The correlation between metabolic syndrome and its components with the degree of coronary artery stenosis and clinical outcomes in patients with acute myocardial infarction[J]. Chinese Journal of General Practice, 2024, 22(2): 212-216. doi: 10.16766/j.cnki.issn.1674-4152.003368
Citation: WANG Kaiyang, LIU Fengshuang, LIU Yongguo, LI Guoqing, YANG Yining, YU Xiaolin. The correlation between metabolic syndrome and its components with the degree of coronary artery stenosis and clinical outcomes in patients with acute myocardial infarction[J]. Chinese Journal of General Practice, 2024, 22(2): 212-216. doi: 10.16766/j.cnki.issn.1674-4152.003368
shu

The correlation between metabolic syndrome and its components with the degree of coronary artery stenosis and clinical outcomes in patients with acute myocardial infarction

doi: 10.16766/j.cnki.issn.1674-4152.003368
  • 1.

    Department of Cardiology, Xinjiang Uygur Autonomous Region People's Hospital, Urumqi, Xinjiang 830000, China

Funds:

 2023D01C91

  • Received Date: 2023-07-19
    Available Online: 2024-03-27
    Abstract
  •   Objective  To explore the correlation between metabolic syndrome (MS) with the degree of coronary artery stenosis and prognosis in patients with acute myocardial infarction (AMI).  Methods  There were 726 AMI patients as the subjects, from the Cardiology Department of Xinjiang Uygur Autonomous Region People's Hospital from January 2019 to December 2020. The Gensini score was used to quantitatively assess the degree of coronary artery stenosis and the clinical outcome was defined as major adverse cardiovascular events (MACEs). Multiple linear regression was used to analyze the correlation between MS and its components between Gensini score. Multivariate Cox regression was used to analyze the independent risk factors for MACEs.  Results  There were 348 patients (47.9%) in the MS group and 378 patients (52.1%) in the non-MS group. Compared with the non-MS group, patients in the MS group were older and had more combined hypertension, diabetes, abdominal obesity, dyslipidemia. Waist circumference, systolic blood pressure, fasting blood glucose, blood urea nitrogen, low density lipoprotein cholesterol and Gensini score were higher, hemoglobin levels were lower, clopidogrel utilization rate was higher and the incidence of MACEs was higher, the differences were statistically significant (P < 0.05). Internal comparison showed that Gensini scores were significantly increased in the group of abdominal obesity and elevated fasting blood glucose (P < 0.05). Multiple linear regression analysis results showed that elevated fasting blood glucose and abdominal obesity were independently correlated with Gensini score. Multivariate Cox regression analysis results showed that: diabetes and abdominal obesity were the independent risk factors for MACEs.  Conclusion  Patients with AMI complicated by MS were very common. Abnormal glucose metabolism and abdominal obesity were closely related to the degree of coronary artery stenosis, and significantly affect the prognosis of patients.

     

    • FullText(HTML)
  • loading
    • References(22)
  • [1]
    陈丹丹, 张慧, 邵静, 等. 代谢综合征患者饮食和运动管理方案最佳证据总结[J]. 浙江大学学报(医学版), 2022, 51(1): 27-37. https://www.cnki.com.cn/Article/CJFDTOTAL-ZJYB202201004.htm

    CHEN D D, ZHANG H, SHAO J, et al. Summary of the best evidence of diet and physical activity management in patients with metabolic syndrome[J]. Journal of Zhejiang University(Medical Sciences), 2022, 51(1): 27-37. https://www.cnki.com.cn/Article/CJFDTOTAL-ZJYB202201004.htm
    [2]
    LIU J, LIU Q, LI Z, et al. Prevalence of metabolic syndrome and risk factors among chinese adults: results from a population-based study-Beijing, China, 2017-2018[J]. China CDC Wkly, 2022, 4(29): 640-645.
    [3]
    费丽萍, 周忠贤, 张容, 等. 泸州市18~60岁体检人群代谢综合征流行现状及影响因素分析[J]. 中国卫生统计, 2023, 40(5): 707-710. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGWT202305016.htm

    FEI L P, ZHOU Z X, ZHANG R, et al. To analyze the prevalence and influencing factors of metabolic syndrome in 18-60 years old physical examination population in Luzhou city[J]. Chinese Journal of Health Statistics, 2023, 40(5): 707-710. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGWT202305016.htm
    [4]
    国家卫生计生委合理用药专家委员会, 中国药师协会. 冠心病合理用药指南(第2版)[J]. 中国医学前沿杂志(电子版), 2018, 10(6): 1-130. https://www.cnki.com.cn/Article/CJFDTOTAL-JRFS202106031.htm

    Expert Committee on Rational Drug Use, National Health and Family Planning Commission, Chinese Pharmacists Association. Guidelines for the rational use of drugs for coronary heart disease (2nd edition)[J]. Chinese Journal of the Frontiers of Medical Science (Electronic Version), 2018, 10(6): 1-130. https://www.cnki.com.cn/Article/CJFDTOTAL-JRFS202106031.htm
    [5]
    DOMMERMUTH R, EWING K. Metabolic syndrome: systems thinking in heart disease[J]. Prim Care, 2018, 45(1): 109-129. doi: 10.1016/j.pop.2017.10.003
    [6]
    LAVIE C J, GERSH B J. Acute myocardial infarction: initial manifestations, management, and prognosis[J]. Mayo Clin Proc, 1990, 65(4): 531-548. doi: 10.1016/S0025-6196(12)60954-9
    [7]
    THYGESEN K, ALPERT J S, JAFFE A S, et al. Fourth universal definition of myocardial infarction (2018)[J]. Glob Heart, 2018, 13(4): 305-338. doi: 10.1016/j.gheart.2018.08.004
    [8]
    REYNOLDS H R, SHAW L J, MIN J K, et al. Outcomes in the ISCHEMIA trial based on coronary artery disease and ischemia severity[J]. Circulation, 2021, 144(13): 1024-1038. doi: 10.1161/CIRCULATIONAHA.120.049755
    [9]
    中华医学会糖尿病学分会. 中国2型糖尿病防治指南(2020年版)(下)[J]. 中国实用内科杂志, 2021, 41(9): 757-784. https://www.cnki.com.cn/Article/CJFDTOTAL-HLSJ202309001.htm

    Diabetes Society of Chinese Medical Association. Chinese Guidelines for the Prevention and Treatment of Type 2 diabetes(2020 Edition)(Ⅱ)[J]. Chinese Journal of Practical Internal Medicine, 2021, 41(9): 757-784. https://www.cnki.com.cn/Article/CJFDTOTAL-HLSJ202309001.htm
    [10]
    中国高血压防治指南修订委员会, 高血压联盟(中国), 中华医学会心血管病学分会中国医师协会高血压专业委员会, 等. 中国高血压防治指南(2018年修订版)[J]. 中国心血管杂志, 2019, 24(1): 24-56. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGGZ201904005.htm

    Chinese Committee for Revision of Guidelines for the Prevention and Treatment of Hypertension, Hypertension Alliance (China), Chinese Society of Cardiology, Chinese Medical Doctor Association, et al. 2018 Chinese guidelines for the management of hypertension[J]. Chinese Journal of Cardiovascular Medicine, 2019, 24(1): 24-56. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGGZ201904005.htm
    [11]
    中华医学会糖尿病学分会. 中国2型糖尿病防治指南(2020年版)(上)[J]. 中国实用内科杂志, 2021, 41(8): 668-695. https://www.cnki.com.cn/Article/CJFDTOTAL-HBYX202112018.htm

    Diabetes Society of Chinese Medical Association. Guideline for the prevention and treatment of type 2 diabetes mellitus in China(2020 edition)(Part 1)[J]. Chinese Journal of Practical Internal Medicine, 2021, 41(8): 668-695. https://www.cnki.com.cn/Article/CJFDTOTAL-HBYX202112018.htm
    [12]
    中华医学会心血管病学分会高血压学组, 中华心血管病杂志编辑委员会. 中国高血压患者血压血脂综合管理的专家共识[J]. 中华心血管病杂志, 2021, 49(6): 554-563.

    Hypertensive Group of Chinese Society of Cardiology of Chinese Medical Association. Expert consensus on the comprehensive management of blood pressure and dyslipidemia in Chinese hypertensive patients[J]. Chinese Journal of Cardiology, 2021, 49(6): 554-563.
    [13]
    WANG K Y, ZHENG Y Y, WU T T, et al. Predictive value of Gensini score in the long-term outcomes of patients with coronary artery disease who underwent PCI[J]. Front Cardiovasc Med, 2021, 8: 778615. DOI: 10.3389/fcvm.2021.778615.
    [14]
    中国心血管健康与疾病报告编写组. 中国心血管健康与疾病报告2021概要[J]. 中国循环杂志, 2022, 37(6): 553-578. https://www.cnki.com.cn/Article/CJFDTOTAL-XFXZ202312019.htm

    The Writing Committee of the Report on Cardiovascular Health and Diseases in China. Report on cardiovascular health and diseases in China 2021: an updated summary[J]. Chinese Circulation Journal, 2022, 37(6): 553-578. https://www.cnki.com.cn/Article/CJFDTOTAL-XFXZ202312019.htm
    [15]
    李耀华, 谢萍. 代谢综合征与冠心病冠状动脉病变相关性分析[J]. 中国循证心血管医学杂志, 2017, 9(1): 41-45. https://www.cnki.com.cn/Article/CJFDTOTAL-PZXX201701013.htm

    LI Y H, XIE P. The correlation between metabolic syndrome and coronary artery lesions in patients with coronary heart disease[J]. Chinese Journal of Evidence-Based Cardiovascular Medicine, 2017, 9(1): 41-45. https://www.cnki.com.cn/Article/CJFDTOTAL-PZXX201701013.htm
    [16]
    秦会敏, 程华. 多层螺旋CT评价腹型肥胖与冠心病Gensini评分的相关性[J]. 中国老年学杂志, 2020, 40(8): 1573-1577. https://www.cnki.com.cn/Article/CJFDTOTAL-ZLXZ202008003.htm

    QIN H M, CHENG H. The correlation between abdominal obesity and coronary heart disease Gensini score evaluated by multi-slice spiral CT[J]. Chinese Journal of Gerontology, 2020, 40(8): 1573-1577. https://www.cnki.com.cn/Article/CJFDTOTAL-ZLXZ202008003.htm
    [17]
    郭明秋, 殷晓捷, 刁殿琰, 等. 脂质代谢水平与冠状动脉粥样硬化病变的关系[J]. 中国动脉硬化杂志, 2021, 29(2): 149-155. https://www.cnki.com.cn/Article/CJFDTOTAL-KDYZ202102010.htm

    GUO M Q, YIN X J, DIAO D Y, et al. Relationship between the levels of lipid metabolism and coronary atherosclerotic lesions[J]. Chinese Journal of Arteriosclerosis, 2021, 29(2): 149-155. https://www.cnki.com.cn/Article/CJFDTOTAL-KDYZ202102010.htm
    [18]
    王欢欢, 贾斯达, 刘越, 等. 代谢综合征及其组分对冠状动脉介入术患者远期预后的影响[J]. 中华医学杂志, 2020, 100(21): 1623-1628.

    WANG H H, JIA S D, LIU Y, et al. The impact of metabolic syndrome and its individual components on long-term prognosis of patients undergoing percutaneous coronary intervention[J]. National Medical Journal of China, 2020, 100(21): 1623-1628.
    [19]
    师瑞, 冯磊, 唐灵通, 等. 糖尿病患者血糖波动评价指标研究进展[J]. 中华全科医学, 2022, 20(12): 2105-2109. doi: 10.16766/j.cnki.issn.1674-4152.002780

    SHI R, FENG L, TANG L T, et al. Research progress on evaluation indicators of blood glucose fluctuation in patients with diabetes[J]. Chinese Journal of General Practice, 2022, 20(12): 2105-2109. doi: 10.16766/j.cnki.issn.1674-4152.002780
    [20]
    赵茂宇, 李佑美, 刘焕云, 等. 胰岛素抵抗标志物在动脉粥样硬化发病中的研究进展[J]. 基础医学与临床, 2022, 42(8): 1302-1305. https://www.cnki.com.cn/Article/CJFDTOTAL-JCYL202208027.htm

    ZHAO M Y, LI Y M, LIU H Y, et al. Research progress of insulin resistance markers in atherogenesis[J]. Basic and Clinical Medicine, 2022, 42(8): 1302-1305. https://www.cnki.com.cn/Article/CJFDTOTAL-JCYL202208027.htm
    [21]
    SALTIEL A R, OLEFSKY J M. Inflammatory mechanisms linking obesity and metabolic disease[J]. J Clin Invest, 2017, 127(1): 21-24.
    [22]
    KUNZ H E, HART C R, GRIES K J, et al. Adipose tissue macrophage populations and inflammation are associated with systemic inflammation and insulin resistance in obesity[J]. Am J Physiol Endocrinol Metab, 2021, 321(1): E105-E121. doi: 10.1152/ajpendo.00070.2021
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Figures(1)  / Tables(4)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (235) PDF downloads(18) Cited by()
    Proportional views
    Related

    Address：No. 287, Changhuai Road, Bengbu, Anhui Province, 233004, P.R.ChinaphoneNo：0552-3066635； 0552-3051890Email：zhqkyx@163.com

    Copyright © Chinese Journal of General Practice皖ICP备2020018345号-2

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return