Volume 22 Issue 2
Feb.  2024
Turn off MathJax
Article Contents
Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(2): 244-246
BAI Xiaohui, HONG Luxi. Clinical study of transvaginal ultrasound monitoring of trazole combined with gonadotropin in the treatment of infertility in polycystic ovary syndrome[J]. Chinese Journal of General Practice, 2024, 22(2): 244-246. doi: 10.16766/j.cnki.issn.1674-4152.003375
Citation: BAI Xiaohui, HONG Luxi. Clinical study of transvaginal ultrasound monitoring of trazole combined with gonadotropin in the treatment of infertility in polycystic ovary syndrome[J]. Chinese Journal of General Practice, 2024, 22(2): 244-246. doi: 10.16766/j.cnki.issn.1674-4152.003375
shu

Clinical study of transvaginal ultrasound monitoring of trazole combined with gonadotropin in the treatment of infertility in polycystic ovary syndrome

doi: 10.16766/j.cnki.issn.1674-4152.003375
  • 1.

    Department of Ultrasound, Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine, Wenzhou, Zhejiang 325000, China

Funds:

 2020KY1064

  • Received Date: 2023-10-30
    Available Online: 2024-03-27
    Abstract
  •   Objective  The main treatment drugs for PCOS are letrozole, but the effect of single drug treatment is not good. This study used vaginal ultrasound technology as a means to evaluate the efficacy of letrozole and gonadotropin drug combination in the treatment of infertility patients with PCOS.  Methods  A total of 86 patients with PCOS treated in Wenzhou Hospital of Integrated Chinese and Western Medicine from January to December 2022 were selected and divided into observation group (43 cases) and control group (43 cases) according to random number table method. The control group was treated with letrozole, and the observation group was treated with letrozole combined with human follicle stimulating hormone. Ovarian parameters, including ovarian volume, maximum ovarian follicle diameter, endometrial thickness and number of follicles, were evaluated by transvaginal ultrasound. Peak systolic flow rate, pulsation index and resistance index of ovarian interstitial artery were compared between the two groups. Levels of follicle-stimulating hormone, estradiol and luteinizing hormone, ovulation rate and pregnancy rate were compared between the two groups.  Results  The ovarian volume and number of follicles in observation group were smaller than those in control group, the maximum ovarian follicle diameter and endometrial thickness were larger than those in control group, and the peak systolic flow rate, pulsation index and resistance index of the ovarian interstitial artery were higher than those in control group, with statistical significance (P < 0.05). Follicle stimulating hormone and estradiol in the observation group were (7.88±1.26) mIU/mL and (162.32±20.07) pmol/L, respectively, which were significantly higher than those in the control group [(4.42±0.61) mIU/mL and (62.46±9.28) pmol/L, P < 0.05]. Luteinizing hormone in observation group was significantly lower than that in control group [(6.29±0.78) mIU/mL vs. (18.42±2.15) mIU/mL, P < 0.05]. The ovulation rate and conception rate in the observation group were significantly higher than those of control group (P < 0.05).  Conclusion  Vaginal ultrasound monitoring can provide good feedback on the treatment of PCOS patients, and gonadotropin drug treatment of PCOS can effectively improve the ovulation rate and pregnancy rate of patients, which has good clinical value.

     

    • FullText(HTML)
  • loading
    • References(16)
  • [1]
    中国中西医结合学会妇产科专业委员会. 多囊卵巢综合征中西医结合诊治指南[J]. 中国中西医结合杂志, 2023, 9(5): 1-14. https://www.cnki.com.cn/Article/CJFDTOTAL-ZZXJ202401001.htm

    Professional Committee of Obstetrics and Gynecology, Chinese Association of Integrated Traditional Chinese and Western Medicine. Guidelines for diagnosis and treatment of polycystic ovary syndrome with Integrated Chinese and Western Medicine[J]. Chinese Journal of Integrated Traditional and Western Medicine, 2023, 9(5): 1-14. https://www.cnki.com.cn/Article/CJFDTOTAL-ZZXJ202401001.htm
    [2]
    任丽娟, 李红英, 谢红英, 等. 经阴道超声在中西医结合治疗多囊卵巢综合征不孕中的临床价值研究[J]. 中国现代医生, 2023, 61(24): 18-21. https://www.cnki.com.cn/Article/CJFDTOTAL-ZDYS202324005.htm

    REN L J, LI H Y, XIE H Y, et al. Clinical value of integrated traditional Chinese and western medicine in the treatment of infertility with polycystic ovarian syndrome by transvaginal ultrasound[J]. China Modern Doctor, 2023, 61(24): 18-21. https://www.cnki.com.cn/Article/CJFDTOTAL-ZDYS202324005.htm
    [3]
    DAHAN M H, DRUBACH N C, MILKI A A. Transvaginal ultrasonographic rates of folliculogenesis among oligomenorrheic women with polycystic ovary syndrome[J]. J Reprod Med, 2016, 61(9-10): 431-435.
    [4]
    柳文琴. 来曲唑联合阿司匹林治疗多囊卵巢综合征导致排卵障碍患者的效果和安全性研究[J]. 中国现代药物应用, 2023, 17(16): 131-133. https://www.cnki.com.cn/Article/CJFDTOTAL-ZWYY202316037.htm

    LIU W Q. Effectiveness and safety of letrozole combined with aspirin in patients with ovulation disorder due to polycystic ovary syndrome[J]. Chinese Journal of Modern Drug Application, 2023, 17(16): 131-133. https://www.cnki.com.cn/Article/CJFDTOTAL-ZWYY202316037.htm
    [5]
    赵芳园, 邹红, 时思毛, 等. 多囊卵巢综合征患者多普勒超声测量参数与性激素、炎性因子水平的相关性分析[J]. 生物医学工程与临床, 2023, 27(5): 594-598. https://www.cnki.com.cn/Article/CJFDTOTAL-SGLC202305008.htm

    ZHAO F Y, ZOU H, SHI S M, et al. Correlation analysis of Doppler ultrasonography parameters with serum levels of sex hormones and inflammatory factors in patients with polycystic ovary syndrome[J]. Biomedical Engineering and Clinical Medicine, 2023, 27(5): 594-598. https://www.cnki.com.cn/Article/CJFDTOTAL-SGLC202305008.htm
    [6]
    谢幸, 苟文丽. 妇产科学[M]. 8版. 北京: 人民卫生出版社, 2013: 359-361.

    XIE X, GOU W L. Gynecology and Obstetrics[M]. 8th Ed. Beijing: People ' s Medical Publishing House, 2013: 359-361.
    [7]
    向玉, 杨惠林, 马英兰, 等. 子宫内膜螺旋动脉血流参数与多囊卵巢综合征不孕症的关系及对体外受精-胚胎移植助孕妊娠结局的判断价值研究[J]. 临床和实验医学杂志, 2023, 22(15): 1643-1646. https://www.cnki.com.cn/Article/CJFDTOTAL-SYLC202315020.htm

    XIANG Y, YANG H L, MA Y L, et al. Relationship between endometrial spiral artery blood flow parameters and infertility of polycystic ovary syndrome and the value of evaluating pregnancy outcome assisted by in vitro fertilization and embryo transfer[J]. Journal of Clinical and Experimental Medicine, 2023, 22(15): 1643-1646. https://www.cnki.com.cn/Article/CJFDTOTAL-SYLC202315020.htm
    [8]
    尤小燕, 张静华, 靳园园, 等. 多囊卵巢综合征合并不良妊娠与自身免疫调控异常的关系[J]. 中国临床医生杂志, 2023, 51(8): 992-996. https://www.cnki.com.cn/Article/CJFDTOTAL-ZLYS202308033.htm

    YOU X Y, ZHANG J H, JIN Y Y, et al. Relationship between polycystic ovary syndrome combined with adverse pregnancy and abnormal autoimmune regulation[J]. Chinese Journal For Clinicians, 2023, 51(8): 992-996. https://www.cnki.com.cn/Article/CJFDTOTAL-ZLYS202308033.htm
    [9]
    丁延华, 周青雪, 朱晓玲, 等. 多囊卵巢综合征患者糖代谢水平对卵巢超声特征的影响[J]. 中华全科医学, 2023, 21(6): 1004-1007. doi: 10.16766/j.cnki.issn.1674-4152.003036

    DING Y H, ZHOU Q X, ZHU X L, et al. Influence of glucose metabolism level on ovarian ultrasound characteristics in patients with polycystic ovary syndrome[J]. Chinese Journal of General Practice, 2023, 21(6): 1004-1007. doi: 10.16766/j.cnki.issn.1674-4152.003036
    [10]
    张典润, 刘晖, 曾令红, 等. 经阴道超声监测针刺联合药物对多囊卵巢综合征患者的治疗效果[J]. 分子影像学杂志, 2023, 46(4): 627-631. https://www.cnki.com.cn/Article/CJFDTOTAL-FZYX202304007.htm

    ZHANG D R, LIU H, ZENG L H, et al. Therapeutic effect of combination of acupuncture and medicine on patients with polycystic ovary syndrome monitored by transvaginal ultrasound[J]. Journal of Molecular Imaging, 2023, 46(4): 627-631. https://www.cnki.com.cn/Article/CJFDTOTAL-FZYX202304007.htm
    [11]
    王婷, 吴芸芳. 多囊卵巢综合征所致不孕患者性激素及代谢指标检测分析[J]. 大医生, 2023, 8(13): 125-127. https://www.cnki.com.cn/Article/CJFDTOTAL-DYIS202313041.htm

    WANG T, WU Y F. Detection of sex hormones and metabolic indexes in infertility patients with polycystic ovary syndrome[J]. Doctor, 2023, 8(13): 125-127. https://www.cnki.com.cn/Article/CJFDTOTAL-DYIS202313041.htm
    [12]
    徐允剑, 金妲娜, 薛亚东. 月经周期各阶段不同中药方剂辅助治疗对多囊卵巢综合征不孕患者卵巢功能及妊娠的影响[J]. 中华全科医学, 2018, 16(4): 626-629. doi: 10.16766/j.cnki.issn.1674-4152.000173

    XU Y J, JIN D N, XUE Y D. Effects of different Chinese medicine prescriptions treating at different stages of menstrual cycle on ovarian function and pregnancy in infertile women with polycystic ovary syndrome[J]. Chinese Journal of General Practice, 2018, 16(4): 626-629. doi: 10.16766/j.cnki.issn.1674-4152.000173
    [13]
    刘诗榕, 蒋莉, 许丹丹. 来曲唑在多囊卵巢综合征促排卵治疗中的应用效果[J]. 临床合理用药, 2023, 16(20): 27-30. https://www.cnki.com.cn/Article/CJFDTOTAL-PLHY202320008.htm

    LIU S R, JIANG L, XU D D. Application effect of letrozole in ovulation induction treatment of polycystic ovary syndrome[J]. Chinese Journal of Clinical Rational Drug Use, 2023, 16(20): 27-30. https://www.cnki.com.cn/Article/CJFDTOTAL-PLHY202320008.htm
    [14]
    SUJATA K, SWOYAM S. 2D and 3D trans-vaginal sonography to determine cut-offs for ovarian volume and follicle number per ovary for diagnosis of polycystic ovary syndrome in indian women[J]. J Reprod Infertil, 2018, 19(3): 146-151.
    [15]
    卢艺, 张静静, 黄嫦嫦, 等. 补肾疏肝调周法联合来曲唑治疗多囊卵巢综合征不孕临床研究[J]. 新中医, 2023, 55(15): 100-104. https://www.cnki.com.cn/Article/CJFDTOTAL-REND202315015.htm

    LU Y, ZHANG J J, HUANG C C, et al. Clinical study on Bushen Shugan Tiaozhou Method combined with letrozole forinfertility due to polycystic ovary syndrome[J]. New Chinese Medicine, 2023, 55(15): 100-104. https://www.cnki.com.cn/Article/CJFDTOTAL-REND202315015.htm
    [16]
    曹佳城, 肖扬, 王素霞. 多囊卵巢综合征不孕患者药物促排卵的风险与防治进展[J]. 中华全科医学, 2023, 21(5): 844-848. doi: 10.16766/j.cnki.issn.1674-4152.002997

    CAO J C, XIAO Y, WANG S X. Research progress on the risk and prevention of ovulation induction in infertile patients with polycystic ovary syndrome[J]. Chinese Journal of General Practice, 2023, 21(5): 844-848. doi: 10.16766/j.cnki.issn.1674-4152.002997
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Tables(4)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (157) PDF downloads(13) Cited by()
    Proportional views
    Related

    Address：No. 287, Changhuai Road, Bengbu, Anhui Province, 233004, P.R.ChinaphoneNo：0552-3066635； 0552-3051890Email：zhqkyx@163.com

    Copyright © Chinese Journal of General Practice皖ICP备2020018345号-2

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return