Sleep patterns and factors influencing sleep in patients with bipolar disorder

WEI Jianhong; FENG Hong

doi:10.16766/j.cnki.issn.1674-4152.003466

Volume 22 Issue 4

Apr. 2024

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Article Navigation > Chinese Journal of General Practice > 2024 > 22(4): 625-628

WEI Jianhong, FENG Hong. Sleep patterns and factors influencing sleep in patients with bipolar disorder[J]. Chinese Journal of General Practice, 2024, 22(4): 625-628. doi: 10.16766/j.cnki.issn.1674-4152.003466

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WEI Jianhong, FENG Hong. Sleep patterns and factors influencing sleep in patients with bipolar disorder[J]. Chinese Journal of General Practice, 2024, 22(4): 625-628. doi: 10.16766/j.cnki.issn.1674-4152.003466

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Sleep patterns and factors influencing sleep in patients with bipolar disorder

doi: 10.16766/j.cnki.issn.1674-4152.003466

WEI Jianhong^{1
,
,}
, FENG Hong²

1.
Department of Neurology, Shaoxing Seventh People' s Hospital (Mental Health Center Affiliated to School of Medicine, Shaoxing University of Arts and Sciences), Shaoxing, Zhejiang 312000, China

Funds:

2022RC279

Received Date: 2023-10-13
Available Online: 2024-05-29

Abstract

Abstract

Objective This study aims to explore the sleep status of patients with bipolar disorder and analyze the related factors affecting the sleep status of patients with bipolar disorder, and to analyze the related factors, and to provide theoretical basis for the sleep management of patients with bipolar disorder. Methods A total of 149 hospitalized patients with bipolar disorder from April 2018 to May 2022 at Shaoxing Seventh People' s Hospital were enrolled in this study. According to their Pittsburgh sleep quality index (PSQI) score, the subjects were divided into two groups: sleep disorder group and non-sleep disorder group. The general data and laboratory test results of both groups were analyzed. Additionally, multivariate stepwise logistic regression with binary variables was conducted to identify factors infulencing the sleep status of patients with bipolar disorder were analyzed by. Results Out of the 149 distributed questionnaires, 142 valid questionnaires were collected. Among them, 24 participants with a PSQI score ≥8 were divided into the sleep disorder group, while 118 participants with a PSQI score < 8 were classified into the non-sleep disorder group. The overall PSQI score for the 142 patients with bipolar disorder was (12.09±3.89) points, indicating a low level of sleep quality. In the sleep disorder group, the levels of melatonin (MLT) and adrenocorticotropic hormone (ACTH) were lower than that of the non-sleep disorder group. Conversely, the levels of homocysteine (Hcy) and cortisol (COR), as well as the scores of Hamilton depression scale (HADA) and Hamilton anxiety scale (HAMA), were higher in the non-sleep disorder group (P < 0.05). Multivariate logistic regression analysis showed that high COR (OR=1.444, 95% CI: 1.127-1.850) and high Hcy (OR=1.875, 95% CI: 1.154-3.047) were risk factors for sleep disorders. Low ACTH (OR=0.758, 95% CI: 0.609-0.943) and low MLT (OR=0.794, 95% CI: 0.700-0.900) were all protective factors for sleep disorders (P < 0.05). Conclusion Sleep disorders are commonly observed in individuals with bipolar disorder, and several factors including MLT, ACTH, Hcy, and COR are associated with the sleep status of these patients.
- Bipolar disorder,
- Sleep,
- Melatonin,
- Influencing factor

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References(30)

References

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Sleep patterns and factors influencing sleep in patients with bipolar disorder

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