Volume 22 Issue 5
May  2024
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Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(5): 828-832
LI Xin, SUN Yan, CHEN Wei, MA Wenyou, YU Zhenjian, ZHANG Shun, LIANG Xiaoliang, LEI Rong. Clinical significance of thyroid hormones, sex hormones, and cortisol levels in assessing the severity of first-episode female depression disorder[J]. Chinese Journal of General Practice, 2024, 22(5): 828-832. doi: 10.16766/j.cnki.issn.1674-4152.003513
Citation: LI Xin, SUN Yan, CHEN Wei, MA Wenyou, YU Zhenjian, ZHANG Shun, LIANG Xiaoliang, LEI Rong. Clinical significance of thyroid hormones, sex hormones, and cortisol levels in assessing the severity of first-episode female depression disorder[J]. Chinese Journal of General Practice, 2024, 22(5): 828-832. doi: 10.16766/j.cnki.issn.1674-4152.003513
shu

Clinical significance of thyroid hormones, sex hormones, and cortisol levels in assessing the severity of first-episode female depression disorder

doi: 10.16766/j.cnki.issn.1674-4152.003513
  • 1.

    Department of Psychiatry, Kailuan Mental Health Center, Tangshan, Hebei 063000, China

Funds:

 20231851

  • Received Date: 2024-01-18
    Available Online: 2024-07-20
    Abstract
  •   Objective   This study aims to investigate the distribution differences of thyroid hormones, sex hormones, and cortisol levels in first-episode female patients with depression across varying severity levels. The goal was to deepen the understanding of the hormonal regulation mechanisms in depression and identify potential biomarkers for clinical diagnosis.   Methods   A total of 150 first-episode female patients with depression hospitalized at the Kailuan Mental Health Center from June 2022 to June 2023 were selected. General information of the patients was collected, and the levels of thyroid hormones (T4, T3, TSH, FT3, FT4), sex hormones (T, PRL, P, E2), adrenocorticotropic hormone (ACTH), and cortisol (COR) were measured. The severity of depression was assessed using the Zung self-rating depression scale (SDS). Based on the SDS scores and clinical diagnosis, patients were divided into a mild-to-moderate depression group (70 patients) and a severe depression group (80 patients). Logistic regression and ROC curve analysis were employed for data analysis.   Results   Patients in the mild-to-moderate depression group exhibited higher levels of FT3 and FT4, while lower levels of TSH, testosterone (T), estradiol (E2), ACTH, and COR compared to the severe depression group (P < 0.05). Low levels of FT3 and high levels of T were identified as potential risk factors for severe episodes in first-episode female patients with depression. The area under the curve (AUC) for diagnosing severe episodes in first-episode female patients with depression based on FT3 and T levels were 0.687 (95% CI: 0.602-0.773, P < 0.001) and 0.654 (95% CI: 0.563-0.744, P=0.001), respectively. At an FT3 level of 3.165 pg/mL, the sensitivity for diagnosing severe episodes was 82.5% with a specificity of 51.4%. Similarly, at a T level of 0.221 ng/mL, the sensitivity was 75.0% with a specificity of 62.9%.   Conclusion   Variations in FT3 and T levels are significantly correlated with the severity of first-episode depression in female patients, providing a new perspective on the study of biomarkers in depressive disorders.

     

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