Volume 22 Issue 7
Jul.  2024
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Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(7): 1209-1211
ZHOU Lei, HUANG Xueshuang, LI Huimin, JIN Xin, WANG Hai. Expression and correlation of four kinds of cytokines in patients with Hashimoto's thyroiditis or papillary thyroid carcinoma[J]. Chinese Journal of General Practice, 2024, 22(7): 1209-1211. doi: 10.16766/j.cnki.issn.1674-4152.003601
Citation: ZHOU Lei, HUANG Xueshuang, LI Huimin, JIN Xin, WANG Hai. Expression and correlation of four kinds of cytokines in patients with Hashimoto's thyroiditis or papillary thyroid carcinoma[J]. Chinese Journal of General Practice, 2024, 22(7): 1209-1211. doi: 10.16766/j.cnki.issn.1674-4152.003601
shu

Expression and correlation of four kinds of cytokines in patients with Hashimoto's thyroiditis or papillary thyroid carcinoma

doi: 10.16766/j.cnki.issn.1674-4152.003601
  • 1.

    Department of Laboratory, Hangzhou Children's Hospital, Hangzhou, zhejiang 310006, China

Funds:

 LGF22H160047

  • Received Date: 2023-11-23
    Available Online: 2024-09-05
    Abstract
  •   Objective  To analyzed the expression of serum Interleukin-2 (IL-2), Interleukin 12 P70 (IL-12P70), interleukin-10 (IL-10) and interleukin-17 (IL-17) in Hashimoto's thyroiditis carcinoma (HT) and papillary thyroid carcinoma (PTC), to investigate the role of 4 kinds of cytokines in HT and PTC.  Methods  Thirty patients with Hashimoto's thyroiditis, 35 patients with papillary thyroid carcinoma, and thirty healthy individuals were selected from Tongde Hospital of Zhejiang Province from July 2022 to June 2023. They were divided into HT group, PTC group, and healthy control group. The serum levels of IL-2, IL-12P70, IL-10, and IL-17 were detected by flow cytometry.  Results  Compared with the healthy control group, the serum levels of IL-2, IL-12P70, and IL-17 were significantly higher in both the PTC and HT groups (P < 0.05). Compared with the HT group, the serum level of IL-10 was significantly increased in the PTC group [(9.46±2.22) pg/mL vs. (7.44±1.97) pg/mL, P < 0.05]. In the HT group, thyroid peroxidase antibody (TPOAb) levels were negatively correlated with the level of IL-10 and positively correlated with the level of IL-17 (P < 0.05). The level of thyroglobulin antibody (TgAb) was negatively correlated with the level of IL-10 (P < 0.05). The levels of IL-2, IL-12P70, IL-10, and IL-17 in thyroid tumor patients showed no significant differences after total thyroidectomy or thyroid gland with isthmus resection(P>0.05).  Conclusion  The serum levels of IL-2, IL-12P70, and IL-17 elevated in PTC and HT patients, while the serum levels of IL-10 decreased in HT patients and correlated with TPOAb and TgAb levels. There were no significant changes in the levels of these cytokines after total thyroidectomy or thyroid gland with isthmus resection in patients with PTC.

     

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    • References(18)
  • [1]
    SUNG H, FERLAY J, SIEGEL R L, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2021, 71(3): 209-249.
    [2]
    中国临床肿瘤学会指南工作委员会. 中国临床肿瘤学会(CSCO)分化型甲状腺癌诊疗指南2021[J]. 肿瘤预防与治疗, 2021, 34(12): 1164-1201. https://www.cnki.com.cn/Article/CJFDTOTAL-SCZF202112014.htm

    Guidelines Working Committee of Chinese Society of Clinical Oncology. Guidelines of Chinese Society of Clinical Oncology(CSCO)Differentiated Thyroid Cancer[J]. Journal of Cancer Control And Treatment, 2021, 34(12): 1164-1201. https://www.cnki.com.cn/Article/CJFDTOTAL-SCZF202112014.htm
    [3]
    傅莉萍, 金剑虹, 王保法, 等. 骨化三醇对桥本甲状腺炎患者TPOAb、TgAb、Th17/Treg相关细胞因子的影响[J]. 浙江医学, 2019, 41(22): 2398-2401. https://www.cnki.com.cn/Article/CJFDTOTAL-ZJYE201922015.htm

    FU L P, JIN J H, WANG B F, et al. Impact of calcitriol on the thyroid peroxidase antibody, thyroglobulin antibody levels and Th17/Treg related cytokines in serum of patients with Hashimoto's thyroiditis[J]. Zhejiang Medical Journal, 2019, 41(22): 2398-2401. https://www.cnki.com.cn/Article/CJFDTOTAL-ZJYE201922015.htm
    [4]
    田文. 甲状腺乳头状癌诊治之中国经验与未来走向[J]. 临床外科杂志, 2020, 28(3): 201-204.

    TIAN W. The Chinese experience and future trend of thyroid cancer diagnosis and treatment[J]. Journal of Clinical Surgery, 2020, 28(3): 201-204.
    [5]
    朱旭东. 桥本氏甲状腺炎患者血清TPOAb、TgAb水平与病情的相关性分析[J]. 检验医学, 2018, 33(10): 903-906. https://www.cnki.com.cn/Article/CJFDTOTAL-SHYY201810009.htm

    ZHU X D. Serum TPOAb and TgAb levels in Hashimoto's thyroiditis patients and their correlations with disease severity[J]. Laboratory Medicine, 2018, 33(10): 903-906. https://www.cnki.com.cn/Article/CJFDTOTAL-SHYY201810009.htm
    [6]
    VARRICCHI G, LOFFREDO S, MARONE G, et al. The immune landscape of thyroid cancer in the context of immune checkpoint inhibition[J]. Int J Mol Sci, 2019, 20(16): 3934. DOI: 10.3390/ijms20163934.
    [7]
    朱冯赟智, 王茜, 何菁, 等. 白介素-2及其受体在自身免疫病发病中作用的研究进展[J]. 中国免疫学杂志, 2023, 39(4): 842-848. https://www.cnki.com.cn/Article/CJFDTOTAL-ZMXZ202304029.htm

    ZHU F Y Z, WANG X, HE J, et al. Advances on role of interleukin-2 and its receptors in development of autoimmune diseases[J]. Chinese Journal of Immunology, 2023, 39(04): 842-848. https://www.cnki.com.cn/Article/CJFDTOTAL-ZMXZ202304029.htm
    [8]
    张滢, 梁楠, 孙辉. 细胞因子与甲状腺乳头状癌: 从分子机制到临床应用的研究现状[J]. 中国实验诊断学, 2022, 26(1): 117-120. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSZD202201035.htm

    ZHANG Y, LIANG N, SUN H. Cytokines and papillary thyroid carcinoma: from molecular mechanism to clinical application[J]. Chinese Journal of Laboratory Diagnosis, 2022, 26(1): 117-120. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSZD202201035.htm
    [9]
    HU J Q, LEI B W, WEN D, et al. IL-2 enhanced MHC class Ⅰ expression in papillary thyroid cancer with Hashimoto's thyroiditis overcomes immune escape in vitro[J]. J Cancer, 2020, 11(14): 4250-4260.
    [10]
    李娜, 连续. IL-12与Th17在自身免疫性甲状腺疾病中的研究进展[J]. 牡丹江医学院学报, 2020, 41(6): 139-142. https://www.cnki.com.cn/Article/CJFDTOTAL-MDJB202006039.htm

    LI N, LIAN X. Research progress of IL-12 and TH17 in autoimmune thyroid disease[J]. Journal of Mudanjiang Medical University, 2020, 41(6): 139-142. https://www.cnki.com.cn/Article/CJFDTOTAL-MDJB202006039.htm
    [11]
    NGUYEN K G, VRABEL M R, MANTOOTH S M, et al. Localized interleukin-12 for cancer immunotherapy[J]. Front Immunol, 2020, 15(11): 575597. DOI: 10.3389/fimmu.2020.575597.
    [12]
    曹纪萍, 赵艳峰, 张亚民, 等. EB病毒感染及XRCC1、IL-10基因多态性与甲状腺癌的关联性分析[J]. 现代生物医学进展, 2023, 23(12): 2371-2376. https://www.cnki.com.cn/Article/CJFDTOTAL-SWCX202312032.htm

    CAO J P, ZHAO Y F, ZHANG Y M, et al. Association of EB Virus Infection and Gene Polymorphisms of XRCC1 and IL-10 with Thyroid Cancer[J]. Progress in Modern Biomedicine, 2023, 23(12): 2371-2376. https://www.cnki.com.cn/Article/CJFDTOTAL-SWCX202312032.htm
    [13]
    代毅, 陈昱幸子, 陈勇, 等. 血清IL-2、IL-6、IL-10与分化型甲状腺癌诊断及侵袭性的相关性分析[J]. 现代实用医学, 2023, 35(5): 620-622, 701. https://www.cnki.com.cn/Article/CJFDTOTAL-NBYX202305018.htm

    DAI Y, CHEN Y X Z, CHEN Y, et al. Serum levels of IL-2, IL-6 and Il-10 were correlated with the diagnosis and invasiveness of differentiated thyroid cancer[J]. Modern Practical Medicine, 2023, 35(5): 620-622, 701. https://www.cnki.com.cn/Article/CJFDTOTAL-NBYX202305018.htm
    [14]
    LU Z W, HU J Q, LIU W L, et al. IL-10 restores MHC Class Ⅰ expression and interferes with immunity in papillary thyroid cancer with hashimoto thyroiditis[J]. Endocrinology, 2020, 161(10): bqaa062. DOI: 10.1210/endocr/bqaa062.
    [15]
    王惟, 张达容, 黄煜琪, 等. 甲状腺癌患者血清IL-17、IL-35、SIL-2R表达水平及其临床意义[J]. 现代生物医学进展, 2018, 18(4): 729-732. https://www.cnki.com.cn/Article/CJFDTOTAL-SWCX201804028.htm

    WANG W, ZHANG D R, HUANG Y Q, et al. Expressions and Clinical Significance of Serum IL-17, IL-35 and SIL-2R in Patients with Thyroid Cancer[J]. Progress in Modern Biomedicine, 2018, 18(4): 729-732. https://www.cnki.com.cn/Article/CJFDTOTAL-SWCX201804028.htm
    [16]
    OZISIK H, CEKIN A, SUNER A, et al. Evaluation of IL-10, MCP-1, IFN gamma, and protectin D1 levels in patients with Hashimoto's thyroiditis[J]. Ir J Med Sci, 2023, 192(1): 177-184.
    [17]
    ARAQUE K A, GUBBI S, KLUBO-GWIEZDZINSKA J. Updates on the management of thyroid cancer[J]. Horm Metab Res, 2020, 52(8): 562-577.
    [18]
    朱光亮, 沈俊, 李晓明, 等. 美洛昔康预处理联合超声引导下喉上神经阻滞在甲状腺癌手术患者围术期中的应用[J]. 中华全科医学, 2022, 20(3): 391-394. doi: 10.16766/j.cnki.issn.1674-4152.002360

    ZHU G L, SHEN J, LI X M, et al. Application of meloxicam pretreatment combined with ultrasound-guided internal branch of superior laryngeal nerve block in perioperative period of radical thyroidectomy patients[J]. Chinese Journal of General Practice, 2022, 20(3): 391-394. doi: 10.16766/j.cnki.issn.1674-4152.002360
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