Volume 22 Issue 9
Sep.  2024
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LIU Yun, LIU Ying, LIU Jiahui, WANG Lu, HOU Wenrui, LI Dianming. Clinical efficacy of afatinib in second-line treatment of advanced squamous cell carcinoma of the lung[J]. Chinese Journal of General Practice, 2024, 22(9): 1491-1495. doi: 10.16766/j.cnki.issn.1674-4152.003666
Citation: LIU Yun, LIU Ying, LIU Jiahui, WANG Lu, HOU Wenrui, LI Dianming. Clinical efficacy of afatinib in second-line treatment of advanced squamous cell carcinoma of the lung[J]. Chinese Journal of General Practice, 2024, 22(9): 1491-1495. doi: 10.16766/j.cnki.issn.1674-4152.003666

Clinical efficacy of afatinib in second-line treatment of advanced squamous cell carcinoma of the lung

doi: 10.16766/j.cnki.issn.1674-4152.003666
Funds:

 KJ2018A0997

 2020byzd120

  • Received Date: 2024-04-11
  •   Objective  To observe the efficacy and adverse reactions of afatinib in the second-line treatment of patients with advanced lung squamous cell carcinoma, and to explore the clinical value.  Methods  A total of 58 patients with advanced lung squamoma with negative driver genes were collected from the First Affiliated Hospital of Bengbu Medical University from March 2020 to October 2022 and afatinib was given orally at 40 mg/d according to the guidelines. When grade 3 or more side reactions occurred, the drug was stopped until the patients recovered, and the dose of re-administration was reduced by 10 mg/time to the lowest 20 mg/d. The patients were evaluated every 6 weeks according to response evaluation criteria in solid tumor 1.1 until the disease progressed, and the therapeutic efficacy and adverse effects were observed.  Results  (1) Clinical efficacy: 0 cases of complete remission, 20 cases of partial remission (34.48%), 18 cases of stable disease (31.04%), 20 cases of progressive disease (34.48%), objective response rate (ORR) was 34.48%, disease control rate (DCR) 65.52%; The median progression-free survival (mPFS) was 4.20 months (95% CI: 3.62-4.78) and the median overall survival (mOS) was 11.60 months (95% CI: 7.99-15.21). (2) Univariate results showed that PS score and underlying diseases were correlated with DCR, mPFS, and mOS, while non-sensitive gene mutation and distant metastasis were correlated with mPFS and mOS, and the differences were statistically significant (P < 0.05). (3) Multiple factors showed that PS score and underlying disease were risk factors for mPFS and mOS, and the differences were statistically significant (P < 0.05). (4) Adverse reactions: diarrhea in 58 cases (100.00%), skin rash in 44 cases (75.86%), and grade 3 adverse reactions, diarrhea in 7 cases (12.07%), skin rash in 5 cases (8.62%), no grade 3 or above adverse events.  Conclusion  Afatinib is an alternative second-line treatment for patients with advanced lung squamous cell carcinoma, with good efficacy and controllable side effects.

     

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