Influence of blood glucose fluctuation, inflammation and immune factors on recurrence of condyloma acuminatum in patients with diabetes

WANG Ying; TU Sheng

doi:10.16766/j.cnki.issn.1674-4152.003672

Volume 22 Issue 9

Sep. 2024

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Article Navigation > Chinese Journal of General Practice > 2024 > 22(9): 1518-1521

WANG Ying, TU Sheng. Influence of blood glucose fluctuation, inflammation and immune factors on recurrence of condyloma acuminatum in patients with diabetes[J]. Chinese Journal of General Practice, 2024, 22(9): 1518-1521. doi: 10.16766/j.cnki.issn.1674-4152.003672

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WANG Ying, TU Sheng. Influence of blood glucose fluctuation, inflammation and immune factors on recurrence of condyloma acuminatum in patients with diabetes[J]. Chinese Journal of General Practice, 2024, 22(9): 1518-1521. doi: 10.16766/j.cnki.issn.1674-4152.003672

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Influence of blood glucose fluctuation, inflammation and immune factors on recurrence of condyloma acuminatum in patients with diabetes

doi: 10.16766/j.cnki.issn.1674-4152.003672

WANG Ying¹
, TU Sheng^{2
,
,}

1.
Department of Dermatology, the People's Hospital of Bozhou, Bozhou, Anhui 236800, China

Funds:

KJ2020A0336

by2023029

Received Date: 2023-12-21

Abstract

Abstract

Objective This study aimed to investigate the correlation between blood glucose fluctuations, interleukin-6 (IL-6), and serum tumor necrosis factor-alpha (TNF-α) levels following CO₂ laser and imiquimod treatment (CO₂-Ⅰ) in patients with diabetes mellitus complicated by anogenital (DMCA), and their association with recurrence rates. Methods A prospective cohort study was conducted on 136 DMCA patients treated with CO₂-Ⅰ at the People's Hospital of Bozhou, from August 2020 to December 2022. Post-treatment, all patients underwent continuous blood glucose monitoring for 72 hours to calculate the mean amplitude of glycemic excursion (MAGE). After discharge, patients were followed up for six months to evaluate short-term recurrence. Patients were divided into a recurrence group and a non-recurrence group based on their post-treatment recurrence status. The impact of blood glucose fluctuations on short-term recurrence in diabetic patients with condyloma acuminatum (DMCA) following CO₂ laser treatment (CO₂-Ⅰ) was analyzed. Results Among the 136 DMCA patients, 34 (25.00%) experienced recurrence, while 102 (75.00%) did not. The recurrence group exhibited significantly higher levels of MAGE, IL-6, and TNF-α compared to the non-recurrence group, with these differences being statistically significant (P < 0.05). Multivariate logistic regression analysis indicated that higher MAGE values (≥3.9 mmol/L, OR=1.527, P < 0.001), higher incidence of anorectal and/or genital erosion (OR=2.786, P=0.016), elevated TNF-α levels (≥6.39 μg/L, OR=1.746, P=0.001), and decreased IL-6 levels (< 5.26 pg/mL, OR=1.725, P=0.001) were risk factors for the recurrence. Conclusion In DMCA patients treated with CO₂-Ⅰ, high MAGE values, increased expression of TNF-α and lower IL-6, and the presence of anorectal and/or genital erosion significantly increase the risk of short-term recurrence. These findings hold certain clinical implications and may provide a basis for prognosis assessment.
- Acromegaly,
- Diabetes mellitus,
- CO₂ laser and imiquimod treatment,
- Blood glucose fluctuation,
- Recurrence

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References(22)

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Influence of blood glucose fluctuation, inflammation and immune factors on recurrence of condyloma acuminatum in patients with diabetes

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Influence of blood glucose fluctuation, inflammation and immune factors on recurrence of condyloma acuminatum in patients with diabetes

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