Volume 22 Issue 9
Sep.  2024
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Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(9): 1530-1532
HAN Yong, TIE Chunmiao, SHEN Nannan. Effect of Shexiang Tongxin Dripping Pills on coronary flow reserve in patients with coronary slow flow phenomenon[J]. Chinese Journal of General Practice, 2024, 22(9): 1530-1532. doi: 10.16766/j.cnki.issn.1674-4152.003675
Citation: HAN Yong, TIE Chunmiao, SHEN Nannan. Effect of Shexiang Tongxin Dripping Pills on coronary flow reserve in patients with coronary slow flow phenomenon[J]. Chinese Journal of General Practice, 2024, 22(9): 1530-1532. doi: 10.16766/j.cnki.issn.1674-4152.003675
shu

Effect of Shexiang Tongxin Dripping Pills on coronary flow reserve in patients with coronary slow flow phenomenon

doi: 10.16766/j.cnki.issn.1674-4152.003675
  • 1.

    Department of Pharmacy, Affiliated Hospital of Shaoxing University, Shaoxing, Zhejiang 312000, China

Funds:

 2023ZYC-A55

 Y202249053

  • Received Date: 2024-02-10
    Abstract
  •   Objective  To investigate the clinical efficacy of Shexiang Tongxin Dripping Pills in treating coronary slow flow phenomenon (CSFP), and to explore its effect on improving coronary flow reserve (CFR) in patients.  Methods  Eighty-eight patients with coronary slow flow who were admitted to Affiliated Hospital of Shaoxing University from January to December 2023 were selected and randomly divided into the control group (n=44) and the observation group (n=44). The control group was given conventional treatment, and the observation group was treated with Shexiang Tongxin Dripping Pills in addition to the conventional treatment. The blood coagulation function, corrected TIMI frame count (CTFC), CFR and inflammatory factors before and after treatment were compared, as well as the adverse reactions after medication.  Results  After 4 weeks of treatment, the thrombin time (TT) in the observation group [(22.56±1.31) s] was higher than that in the control group [(19.53±1.94) s], and the difference was statistically significant (P < 0.05). Similarly, the prothrombin time (PT) in the observation group [(13.41±1.16) s] was higher than that in the control group [(12.19±0.99) s] with a statistically significant difference as well (P < 0.05). Additionally, the activated partial thromboplastin time (APTT) in the observation group [(42.80±3.83) s] was also higher compared to APTT [(38.74±4.17) s] in the control group (P < 0.05). On contrary, fibrinogen (Fib) in the observation group [(2.03±0.43) g/L] was lower than the control group [(2.38±0.49) g/L] with statistically significant difference (F=56.916, P < 0.05). The levels of CTFC and basal flow velocity (BFV) in the observation group were lower than those in the control group, while the maximal flow velocity (MFV) and CFR levels were higher than those in the control group (P < 0.05). The levels of hypersensitive C-reactive protein (hs-CRP) and interleukin-6 (IL-6) in the observation group were lower than those in the control group (P < 0.05). There was no statistically significant difference in adverse reactions between two groups (P > 0.05).  Conclusion  Shexiang Tongxin Dripping Pills have better effect in the treatment of patients with coronary slow flow, it can relieve the clinical symptoms of patients, improve the coagulation function and inflammatory factors significantly, and can increase CFR, while having fewer adverse reactions.

     

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