Volume 22 Issue 9
Sep.  2024
Turn off MathJax
Article Contents
Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(9): 1567-1570
SONG Hongtao, MEI Anchang, LIU Xian, TAO Qing, LI Jingya, JIAO Dongliang. Study on the characteristics and diagnostic value of 1H-MRS on the frontal lobe in patients with first-episode depressive disorder[J]. Chinese Journal of General Practice, 2024, 22(9): 1567-1570. doi: 10.16766/j.cnki.issn.1674-4152.003684
Citation: SONG Hongtao, MEI Anchang, LIU Xian, TAO Qing, LI Jingya, JIAO Dongliang. Study on the characteristics and diagnostic value of 1H-MRS on the frontal lobe in patients with first-episode depressive disorder[J]. Chinese Journal of General Practice, 2024, 22(9): 1567-1570. doi: 10.16766/j.cnki.issn.1674-4152.003684
shu

Study on the characteristics and diagnostic value of 1H-MRS on the frontal lobe in patients with first-episode depressive disorder

doi: 10.16766/j.cnki.issn.1674-4152.003684
  • 1.

    Department of Psychiatry, Bengbu First People ' s Hospital, Bengbu, Anhui 233000, China

Funds:

 2020byzd366

 AHWJ2022a029

  • Received Date: 2023-12-15
    Abstract
  •   Objective  To analyze the characteristics of prefrontal lobe proton MR spectroscopy (1H-MRS) in patients with first-episode depressive disorder and evaluate its diagnostic value.  Methods  From January 2021 to December 2022, 40 patients with first-episode depressive disorder who met the criteria and exclusion criteria were randomly selected as the study group according to the medical record number in the Bengbu First People ' s Hospital, while 40 healthy persons were randomly selected in Bengbu First People ' s Hospital Physical Examination Center as the control group. The 1H-MRS indexes of the subjects were collected by superconducting magnetic resonance imaging system. The general information of the study subjects was collected using a self-made general situation questionnaire. The collected data was organized and entered into the database. The chi square test, independent sample t-test and construct ROC curve on the data were analyzed by SPSS 20.0.  Results  (1) There was no significant difference in the distribution of sex, education, marriage, only child status, or age between the study group and the control group (P > 0.05). (2) The value of N-acetyl-based aspartate acid (NAA) / creatine (Cr) (1.74±0.73) in the study group was significantly lower than that in the control group (2.03±0.48, P < 0.05), while there was no significant difference in choline complex (Cho)/Cr between the study group (1.07±0.53) and the control group (1.11±0.31, P > 0.05). (3) Using NAA/Cr value as the test variable, and the study group and control group as state variables (study group=1, control group=0), ROC curves were constructed. NAA/Cr value demonstrated a certain predictive effect for first-episode depressive disorder (AUC=0.664, P=0.012).  Conclusion  Patients with first-onset depression show significantly reduced NAA/Cr values and decreased neuronal function in the frontal lobe. NAA/Cr is a valuable objective indicator for diagnosing first-onset depression.

     

    • FullText(HTML)
  • loading
    • References(16)
  • [1]
    HUANG Y Q, WANG Y, WANG H, et al. Prevalence of mental disorders in China: a cross-sectional epidemiological study[J]. Lancet Psychiatry, 2019, 6(3): 211-224. doi: 10.1016/S2215-0366(18)30511-X
    [2]
    邸烨, 张凤丽, 张成梅, 等. 2017—2021年重度抑郁症患者院内自杀行为的调查及影响因素分析[J]. 上海预防医学, 2024, 36(2): 192-196.

    DI Y, ZHANG F L, ZHANG C M, et al. 2017 to 2021 suicidal behavior in hospitalized patients with major depression and the influencing factors[J]. Shanghai Journal of Preventive Medicine, 2024, 36(2): 192-196.
    [3]
    胡寅田, 胡希文. 老年住院患者衰弱综合征与认知功能障碍和抑郁的相关性分析[J]. 中华全科医学, 2022, 20(11): 1913-1915, 1986. doi: 10.16766/j.cnki.issn.1674-4152.002734

    HU Y T, HU X W. Correlation analysis of frailty syndrome with cognitive dysfunction and depression among elderly inpatients[J]. Chinese Journal of General Practice, 2022, 20(11): 1913-1915, 1986. doi: 10.16766/j.cnki.issn.1674-4152.002734
    [4]
    王晓航, 刘取芝. 自悯训练对抑郁症状的干预效果及影响因素的meta分析[J]. 中华全科医学, 2023, 21(1): 144-148. doi: 10.16766/j.cnki.issn.1674-4152.002832

    WANG X H, LIU Q Z. Meta-analysis of the intervention effect of self-compassion training on depressive symptoms and its influencing factors[J]. Chinese Journal of General Practice, 2023, 21(1): 144-148. doi: 10.16766/j.cnki.issn.1674-4152.002832
    [5]
    刘文娟, 宋明芬, 王伟, 等. 重复经颅磁刺激联合舍曲林对产后抑郁症患者抑郁症状及外周血相关miR表达的影响[J]. 中华全科医学, 2021, 19(3): 441-445. doi: 10.16766/j.cnki.issn.1674-4152.001831

    LIU W J, SONG M F, WANG W, et al. Effects of repetitive transcranial magnetic stimulation combined with sertraline on depressive symptoms and related miR-expression in peripheral blood of patients with postpartum depression[J]. Chinese Journal of General Practice, 2021, 19(3): 441-445. doi: 10.16766/j.cnki.issn.1674-4152.001831
    [6]
    王月洁, 龙镜亦, 刘连忠. 青少年抑郁症脑代谢磁共振波谱研究进展[J]. 国际精神病学杂志, 2023, 50(4): 605-607, 611.

    WANG Y J, LONG J Y, LIU L Z. Research Progress on Brain Metabolic Magnetic Resonance Spectroscopy in Adolescent Depression[J]. Journal of International Psychiatry, 2023, 50(4): 605-607, 611.
    [7]
    XIE X F, SHI Y, MA L, et al. Altered neurometabolite levels in the brains of patients with depression: a systematic analysis of magnetic resonance spectroscopy studies[J]. J Affect Disord, 2023, 328: 95-102.
    [8]
    任红娜, 朱翔, 谢宇航, 等. 基于定量磁共振波谱探讨重度抑郁症患者海马代谢与治疗反应的关系[J]. 浙江医学, 2023, 45(11): 1157-1161.

    REN H N, ZHU X, XIE Y H, et al. Evaluation of treatment response of patients with major depressive disorder based on quantitative magnetic resonance spectroscopy[J]. Zhejiang Medical Journal, 2023, 45(11): 1157-1161.
    [9]
    冯若涵, 卓丽华, 李宏伟, 等. 青少年抑郁症患者海马磁共振成像研究进展[J]. 磁共振成像, 2023, 14(4): 120-125.

    FENG R H, ZHUO L H, LI H W, et al. MRI advances of hippocampus in adolescents with depression[J]. Chinese Journal of Magnetic Resonance Imaging, 2023, 14(4): 120-125.
    [10]
    ŞENDUR I, KALKAN OǦUZHANOǦLU N, SÖZERI VARMA G. Study on dorsolateral prefrontal cortex neurochemical metabolite levels of patients with major depression using H-MRS technique[J]. Turk Psikiyatri Derg, 2020, 31(2): 75-83.
    [11]
    WANG J C, ZHOU T, LIU J H, et al. Application of 1H-MRS in end-stage renal disease with depression[J]. BMC Nephrol, 2020, 21(1): 225.
    [12]
    ZHANG Y L, LAI S H, WU W G, et al. Associations between executive function impairment and biochemical abnormalities in depressed adolescents with non-suicidal self-injury[J]. J Affect Disord, 2022, 298(Pt A): 492-499.
    [13]
    CHEN Y X, LI X Z, WANG L B, et al. Effects of repetitive transcranial magnetic stimulation on cognitive function in patients with stress-related depression: a randomized double-Blind fMRI and 1H-MRS study[J]. Front Neurol, 2022, 13: 844606. DOI: 10.3389/fneur.2022.844606.
    [14]
    苗浩飞. 伴童年创伤抑郁症患者中枢执行系统损害与氢质子磁共振波谱研究[D]. 广州: 暨南大学, 2021.

    MIAO H F. Central Executive System impairing and Hydrogen Proton Magnetic Resonance Spectroscopy in Major Depressive Disorder patients with childhood trauma[D]. Guangzhou: Jinan University, 2021.
    [15]
    GUENTER W, BIELIN ' SKI M, BONEK R, BORKOWSKA A. Neurochemical changes in the brain and neuropsychiatric symptoms in clinically isolated syndrome[J]. J Clin Med, 2020, 9(12): 3909. DOI: 10.3390/jcm9123909.
    [16]
    PIERSSON A D, MOHAMAD M, RAJAB F, et al. Cerebrospinal fluid amyloid beta, tau levels, apolipoprotein, and 1H-MRS brain metabolites in Alzheimer ' s disease: a systematic review[J]. Acad Radiol, 2021, 28(10): 1447-1463.
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Figures(1)  / Tables(2)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (16) PDF downloads(2) Cited by()
    Proportional views
    Related

    Address：No. 287, Changhuai Road, Bengbu, Anhui Province, 233004, P.R.ChinaphoneNo：0552-3066635； 0552-3051890Email：zhqkyx@163.com

    Copyright © Chinese Journal of General Practice皖ICP备2020018345号-2

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return