Correlation of abnormal calcium-phosphorus homeostasis and heart malfunction patients with chronic kidney disease

Objective To analyze the relationship between the calcium-phosphorus metabolic profiles and cardiac malfunction characteristics in the chronic kidney disease(CKD) patients,discuss the role of calcium phosphorus metabolism in the heart damage,and provide reference for the privation of cardiovascular events in CKD patients. Methods A total number of 98 inpatients at stages of CKD3,CKD4 and CKD5 were recruited.Fasting venous blood was taken and calcium-phosphorus metabolic indices,including serum calcium,serum phosphate(Pi),intact parathyroid hormone(iPTH),β-collagen-specific sequences,total N-terminal propeptide of type Ⅰ procollagen(TPINP),and N-terminal-midfragment of ostecalcin(N-MID) were measured via electrochemiluminescence.Cardiac damage parameters,including left ventricular end diastolic diameter,interventricular septal thickness,left ventricular posterior wall thickness,ejection fraction(EF),and blood flow velocity at mitral diastolic late phase(A) and at mitral diastolic early phase(E) were obtained from echocardiography. Results There was an escalating trend in deteriorating calcium-phosphorus metabolic indices for patients from stage CKD3 to stage CKD5(P<0.05).Among 98 patients,35.7%(n=36) had myocardial hypertrophy,71.4%(n=70) had the diastolic dysfunction,and 27.5%(n=27) had systolic dysfunction.Correlations between abnormal calcium-phosphorus metabolic indices,such as β-CTX,N-MID,TP1NP,Pi,and iPTH,with myocardial hypertrophy,cardiac systolic indicator EF and the A/E value,diastolic dysfunction index,were evidenced. Conclusion In the context of kidney dysfunction,the abnormalities of calcium-phosphorus homeostasis may contribute to cardiac malfunction in CKD patients.