Influence of different doses of rosuvastatin on inflammatory factors,endothelial function and visfatin levels in patients with unstable angina pectoris

Objective To compare the influence of different doses of Rosuvastatin on inflammatory factors,endothelial function and Visfatin levels in patients with unstable angina pectoris and its safety. Methods A total of 120 cases of unstable angina pectoris in our hospital between February,2011 and May,2015 were enrolled and randomly divided into observation group and control group with 60 cases in each group.All patients received the routine therapy.The patients in the control group received orally 10 mg Rosuvastatin,1 time a day,while the patients in the observation group received orally 20 mg Rosuvastatin,1 time a day,the course in both groups was 12 months.After the treatment,the levels of HIF-1α,visfatin,TNF-α,vWF,ET-1,NO and hs-CRP were tested.The endothelial function in both groups was determined.The incidence of cardiovascular adverse events during the treatment and adverse drug reactions were recorded. Results After the treatment,the serum alpha HIF-1,Visfatin,TNF alpha,hs-CRP,vWF and ET-1 levels in both groups decreased,more obviously in the observation group as compared with the control group.The serum NO level was increased in both groups,especially in the observation group,the difference between the two groups was significant(P<0.05).After the treatment,the baseline artery diameter,lumen diameter during inflation and flow mediated dilation(FMD)were increased,especially in the observation group,the difference between the two groups was significant(P<0.05).The incidence of adverse cardiovascular events in the observation group was significantly lower than that in the control group,and the difference was statistical significant(P<0.05).The incidence of abnormal liver function in the observation group was higher than that in the control group,the difference was statistically significant(P<0.05). Conclusion The high-dose Rosuvastatin for unstable angina pectoris have a better comprehensive clinical efficacy as compared with the routine dose,it can obviously improve the long-term efficacy,however,the incidence of adverse reactions is dose-related,and therefore the pros and cons should be weighed during the clinical use.