Outcome analysis of ASCUS by cervical thin-prep cytology test in postmenopausal women

Objective To explore the outcome of cervical atypical squamous cells of undetermined significance(ASCUS) in postmenopausal women. Methods Between January,2013 and December,2014,712 cases of ASCUS by thin-prep cytology test(TCT)in Ruian City Hospital were enrolled and divided into postmenopausal group and premenopausal group.TCT results,positive rate of ASCUS and high-grade TCT,outcome of ASCUS,and the correlation of ASCUS outcome and HPV infection were observed in both groups. Results The positive rate of ASCUS in the postmenopausal group was lower than that of premenopausal group,but the difference was not statistically significant (P>0.05);the positive rate of cervical squamous intraepithelial lesion in the postmenopausal group was lower than that of the premenopausal group(P<0.05),the positive rate of cervical cancer in postmenopausal group was higher than that of premenopausal group(P<0.05);and the different of ASCUS outcome between the postmenopausal group and premenopausal group women was statistically significant(P<0.05),the proportion of high-grade lesions and cervical squamous cell carcinoma in the postmenopausal group were higher than that of the premenopausal group,the proportion of benign in postmenopausal group was lower than that of premenopausal group;In the postmenopausal group,22 cases of ASCUS developed a high-level disease associated with HPV infection,in which 21 cases were high-risk HPV infection;9 cases developed a cervical squamous cell carcinoma,and all of them were with high-risk HPV infection.In the premenopausal group,15 cases of ASCUS developed a high-level disease combined with HPV infection,all 15 cases were with high-risk HPV infection;9 cases developed a cervical squamous cell carcinoma combined with HPV infection,all 9 cases were with high-risk HPV infection. Conclusion The positive rate of ASCUS in postmenopausal women is lower,but ASCUS developing high-level lesions and cervical cancer is higher as compared with the premenopausal women,and the ASCUS outcome are closely related to high-risk HPV infection.