Clinical effect analysis of Jiawei Bufei decoction on COPD with depression

Objective To investigate the clinical effect of Jiawei Bufei decoction on chronic obstructive pulmonary disease (COPD) with depression and its influences on TCM syndrome score,depression status,serum inflammatory factors and immune function. Methods Two hundred and fifty-six cases of COPD with depression patients from January,2015 to June,2016 were randomly divided into two groups,with 128 cases in each group.he control group was treated with conventional western medicine,and the observation group was added with Jiawei Bufei decoction.Before and after treatment,the TCM syndromes scores,depression scores,serum inflammatory factors,and immune function of two groups were detected.And the clinical curative effect was accounted. Results After treatment,the TCM syndrome scores of two groups were significantly reduced (P<0.05),and the TCM syndrome scores of observation group were significantly lower than those of the control group (P<0.05).After treatment,HAMA and HAMD of two groups were significantly reduced (P<0.05),and HAMA and HAMD of observation group were significantly lower than those of control group (P<0.05).After treatment,TNF-α and IL-6 of two groups were significantly reduced (P<0.05),and TNF-α and IL-6 of observation group were significantly lower than those of control group (P<0.05).After treatment,IgM,IgG and IgA levels of two groups were significantly increased (P<0.05),and IgM,IgG and IgA levels of observation group were significantly higher than those of control group (P<0.05).The total effective rate of observation group was 89.7%,which was significantly higher than that of control group 77.0%(P<0.05). Conclusion Based on routine western medicine treatment,Jiawei Bufei decoction could effectively reduce the serum inflammatory factors,improve immune function and alleviate the clinical symptoms of COPD with depression patients.