Effect of preemptive analgesia with parecoxib sodium at different time-point on postoperative analgesia elderly patients undergoing radical resection of gastric cancer

Objective To observe the effect of preemptive analgesia with parecoxib sodium at different time-point on postoperative analgesia elderly patients undergoing radical resection of gastric cancer,and to evaluate the security. Methods We retrospectively analyzed the clinical data of 78 patients undergoing radical surgery in elderly patients with gastric cancer.They were randomly divided into observation group(A) and control group(B).Intravenous parecoxib sodium 40 mg was performed in Group A before the induction of anesthesia,and in the Group B at the end of operation.Then the patient-controlled intravenous analgesia pump was used in both groups at the end of the operation:Sufentanil 0.8 g/(kg·d),ondansetron 16 mg and dezocine 10 mg were configured for 100 ml with saline;Parameters:speed 2 ml/h,automatic control 15 min,2 ml/time.The mean arterial pressure(MAP) and heart rate(HR) at the end of operation,6 h,24 h and 48 h after the surgery were compared between the two groups.The visual analogue scale(VAS),pressing times of the patient-controlled intravenous analgesia pump within 24 h after the operation,and the total dose of Sufentanil were recorded.The incidence of adverse reactions of the two groups was observed. Results MAP and HR in the observation group at the end of operation and 24 h after the operation were lower than those in the control group(P<0.05),with more stable hemodynamics;VAS of the patients in the observation group at 6 h,12 h and 24 h after the operation was lower than the control group(P<0.05).The total pressing times and the total dose of Sufentanil in the observation group were lower than those in the control group(P<0.05).There was no significant difference in the incidence of adverse effects between the two groups(P>0.05). Conclusion The preemptive analgesia with parecoxib sodium before the induction of anesthesia can effective reduce the postsurgical pain in elderly patients undergoing radical resection of gastric cancer,with stable hemodynamics,lower incidence of adverse effect and good safety.