Levels of serum high mobility group protein B1 and its related factors in patients with type 2 diabetes mellitus complicated with lacunar cerebral infarct

Objective To explore the serum high mobility group protein B1 and its related factors in patients with type 2 diabetes mellitus complicated with lacunar cerebral infarction. Methods Total 280 patients with type 2 diabetes mellitus complicated with lacunar infarction were selected as diabetes mellitus + cerebral infarction group, 280 cases of type 2 diabetes mellitus were selected as the diabetic group, and 280 cases of healthy subjects were selected as control group. The levels of serum high mobility group protein B1 and fasting blood glucose (FBG), glycated hemoglobin (HbA1c), fasting insulin (FINS), Insulin resistance index (HOMA-IR), Triglycerides (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) were tested. Results The level of serum high mobility group protein B1 in diabetes group and diabetes + cerebral infarction group was higher than that in the control group (P<0.05), and the blood in diabetic group + cerebral infarction group was higher than that in the diabetes group (P<0.05). FBG, HbA1c, FINS, HOMA-IR, TG, TC and LDL-C in diabetes group and diabetes mellitus + cerebral infarction group were higher than those in the control group, and their levels in the diabetes mellitus + cerebral infarction group was higher than that in the diabetic group; HDL-C level in the diabetes group and diabetes mellitus + cerebral infarction group were lower than that in the control group, and HDL-C in the diabetic group and cerebral infarction group were lower than that in the diabetic group (P<0.05). The level of serum high mobility group protein B1 in patients with diabetes and cerebral infarction was positively correlated with FBG, HbA1c, FINS, HOMA-IR, TG, TC and LDL-C levels (P<0.05), and negatively correlated with HDL-C (P<0.05). FINS, HOMA-IR, TG, TC, LDL-C, HDL-C were the factors affecting the serum high mobility group protein B1 (P<0.05). Conclusion The levels of serum high mobility group protein B1 in patients with type 2 diabetes mellitus complicated with lacunar infarction rise obviously, and can be affected by FINS, HOMA-IR, TG, TC, LDL-C and HDL-C.