Serum iPTH, plasma BNP and NT-proBNP levels for the evaluation of cardiac function in patients with stage 5 chronic kidney disease

Objective To evaluate the value of serum iPTH, plasma BNP and NT-proBNP in the evaluation of cardiac function in patients stage 5 with chronic kidney disease (CKD). Methods Eighty stage 5 CKD patients with varying degrees of heart failure were selected to compare the serum iPTH, plasma BNP, NT-proBNP levels and echocardiography. Among them, there were 23 NYHA functional class Ⅰ (Group A), 40 class Ⅱ (Group B), and 17 class Ⅲ-Ⅳ (Group C). 30 healthy volunteers were selected as controls. The differences in serum iPTH, plasma BNP, and NT-proBNP levels and echocardiography among the three groups were compared, and their correlation with cardiac function was analyzed. Results Serum levels of iPTH, plasma BNP and NT-proBNP were significantly higher in patients in group A, B, and C than those in the control (P<0.01). The levels of LVEDd, LVEDs, IVST, and LVMI were significantly higher in group A, B, and C than those in the control group, and the levels of LVEF and FS were significantly lower than those in the control group (P<0.05). Serum iPTH, plasma BNP and NT-proBNP levels were all strongly correlated with cardiac function parameters, and LVEDd, LVEDs, IVST, LVMI were positively correlated with serum iPTH, plasma BNP and NT-proBNP levels. LVEF and FS were negatively correlated with serum iPTH, plasma BNP and NT-proBNP levels (P<0.05). Conclusion Serum iPTH, plasma BNP and NT-proBNP levels are closely associated with cardiac function in the patients with stage 5 CKD, with higher value in the assessment of cardiac function of patients.