Objective To explore the value of bone metabolic indexes in the diagnosis, treatment and prognosis evaluation of bone metastases in patients with lung cancer.
Methods A total of 108 patients with lung cancer in Yongkang Hospital of Traditional Chinese Medicine were selected, 58 patients with bone metastasis of lung cancer were included in the bone metastasis group, 50 patients without bone metastases were included in the boneless metastasis group, and 50 healthy people in the same period were included in the control group. The levels of total type procollagen Ⅰ amino-terminal propeptide (TPINP) and N-terminal molecular fragments of osteocalcin (N-MID) before and after treatment in the three groups were compared.
Results The levels of TPINP and N-MID in the bone metastasis group and boneless metastasis group were significantly higher than those in control group (
P<0.05), and the levels of TPINP and N-MID in bone metastasis group were significantly higher than those in boneless metastasis group (
P<0.05). The AUC of TPINP and N-MID in the diagnosis of bone metastases in patients with lung cancer were 0.887 and 0.701 respectively, there was a significant difference between the two groups (
P<0.05). The levels of TPINP and N-MID in relieved patients after treatment were significantly lower than those before treatment (
P<0.05). There was no significant difference in TPINP and N-MID levels between patients without remission or worsening before and after treatment (
P>0.05). The levels of TPINP and N-MID in relieved patients were significantly lower than those of patients without remission or worsening (
P<0.05). The median survival time of patients with TPINP>72.36 μg/L was significantly higher than that of patients with TPINP ≤ 72.36 μg/L (
P<0.05). There was no significant difference in the median survival time between the patients with N-MID>17.58 μg/L and N-MID ≤ 17.58 μg/L.
Conclusion The levels of TPINP and N-MID can be used as effective indicators for the diagnosis and treatment evaluation of bone metastases in patients with lung cancer, and TPINP has a certain effect on the prognosis of patients with lung cancer.
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